A graft device is provided comprising a flow conduit and a surrounding covering. The graft device can connect a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation
A graft device is provided comprising a flow conduit and a surrounding covering. The graft device can connect a first body space and a second body space. In one embodiment, the flow conduit is a vein, such as a harvested saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided are methods of preparing a graft device and connecting the graft device between a first body space and a second body space, such as the aorta and a location on an occluded coronary artery, distal to the occlusion.
대표청구항▼
1. A graft device for a patient, comprising: a tubular flow conduit comprising an inner wall, an outer wall, a proximal end, a distal end, and a lumen therethrough; anda tubular covering, said tubular covering surrounding a length of the tubular flow conduit and having an elastically biased curvilin
1. A graft device for a patient, comprising: a tubular flow conduit comprising an inner wall, an outer wall, a proximal end, a distal end, and a lumen therethrough; anda tubular covering, said tubular covering surrounding a length of the tubular flow conduit and having an elastically biased curvilinear geometry customized for an anatomical geometry of an area of said patient;wherein said tubular covering is configured to impart an elastic curvilinear bias to the graft device, andwherein the graft device is constructed and arranged for connection between a first body space and a second body space. 2. The graft device of claim 1, wherein the graft device comprises a varying geometry cross section from the proximal end to the distal end of the tubular flow conduit. 3. The graft device of claim 1, wherein said anatomical geometry of an area of said patient is determined from an image produced by an instrument selected from the group consisting of: X-ray; MRI; Ct-Scan; NMR; Ultrasound; CCD Camera; film camera; and any combinations thereof. 4. The graft device of claim 1, wherein the tubular flow conduit comprises a tissue structure. 5. The graft device of claim 4, wherein the tissue structure is selected from the group consisting of: bone; skin; eustachian tube; artery; vein; urethra; lympathic duct; nasal channel; intestine; esophagus; ureter; urethra; trachea; bronchi; duct; fallopian tube; and combinations thereof. 6. The graft device of claim 4, wherein the tissue structure is selected from the group consisting of: autologous tissue; allogenic tissue; xenogenic tissue; and combinations thereof. 7. The graft device of claim 4, wherein the tissue structure comprises a hollow tissue structure. 8. The graft device of claim 7, wherein the hollow tissue structure is selected from the group consisting of: eustachian tube; artery; vein; urethra; intestine; esophagus; ureter; urethra; trachea; fallopian tube; and combinations thereof. 9. The graft device of claim 4, wherein the tissue structure comprises a blood vessel. 10. The graft device of claim 4, wherein the tissue structure comprises cultured tissue. 11. The graft device of claim 10, wherein the cultured tissue is tissue grown proximate a tubular scaffold. 12. The graft device of claim 10, wherein the cultured tissue is tissue grown on a relatively flat plate. 13. The graft device of claim 10, wherein the cultured tissue is tissue grown in situ. 14. The graft device of claim 1, wherein the tubular flow conduit comprises an artificial conduit. 15. The graft device of claim 14, wherein the artificial conduit comprises material selected from the group consisting of: PFFE; ePTFE; PVDF-HFP; silicone; and combinations thereof. 16. The graft device of claim 1, wherein the tubular flow conduit comprises an artificial conduit and a tissue. 17. The graft device of claim 1, wherein the tubular covering comprises a polymer. 18. The graft device of claim 17, wherein the tubular covering comprises an electrospun polymer. 19. The graft device of claim 1, wherein the tubular covering comprises a fiber form. 20. The graft device of claim 19, wherein the fiber form comprises an electrospun fiber. 21. The graft device of claim 19, wherein the fiber form comprises a spooled fiber. 22. The graft device of claim 1, wherein the tubular covering is constructed and arranged to resist radial expansion of the tubular flow conduit. 23. The graft device of claim 1, wherein the tubular covering comprises an elongated tube constructed and arranged to slidingly receive the tubular flow conduit. 24. The graft device of claim 23, wherein the tubular covering is constructed and arranged to be shrunk after placement around the tubular flow conduit. 25. The graft device of claim 1, wherein the tubular covering comprises a helical coil constructed and arranged to surround the tubular flow conduit. 26. The graft device of claim 23, wherein the tubular covering is constructed and arranged to be expanded prior to slidingly receiving the tubular flow conduit. 27. The graft device of claim 1, wherein the tubular covering is constructed and arranged to support an anastomotic connection. 28. The graft device of claim 1, wherein the tubular covering comprises a slit tube constructed and arranged to surround the tubular flow conduit.
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