A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate
A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use.
대표청구항▼
1. A method of delivering fluid to an eye of a subject as an ejected stream of droplets, comprising: generating the ejected stream of droplets via a droplet generating device, the droplet generating device including an ejector plate, the ejector plate including a plurality of openings formed therein
1. A method of delivering fluid to an eye of a subject as an ejected stream of droplets, comprising: generating the ejected stream of droplets via a droplet generating device, the droplet generating device including an ejector plate, the ejector plate including a plurality of openings formed therein, a fluid delivery area adjacent the ejector plate, and a piezoelectric actuator coupled to the ejector plate, the piezoelectric actuator being coupled to the ejector plate to oscillate the ejector plate; wherein the ejected stream of droplets is generated by actuating the piezoelectric actuator to oscillate the ejector plate, the droplets being ejected through the plurality of openings in the ejector plate; and delivering the ejected stream of droplets to the eye of the subject, wherein the ejected stream of droplets have an average ejected droplet diameter of 25 microns to 75 microns and an average initial droplet ejecting velocity of 2 m/s to 20 m/s, the ejected stream of droplets being generated to deliver a dose of fluid to the eye with a duration of delivery of between 25 ms to 200 ms, wherein between 85% to 100% of the droplets are deposited on the eye. 2. The method of claim 1, wherein the ejected stream of droplets are generated so as to provide the dose of fluid to the eye in more than one pulse of droplet ejection. 3. The method of claim 2, wherein the pulses are generated with stop times separating the pulses. 4. The method of claim 1, further comprising charging the ejected stream of droplets ejected to aid in contact with the eye. 5. The method of claim 4, wherein the ejected stream of droplets is charged by tribocharging as the fluid passes through the plurality of openings in the ejector plate thereby charging the droplets. 6. The method of claim 4, wherein the ejected stream of droplets is charged by applying a voltage to the ejector plate and charging the droplets by induction. 7. The method of claim 4, wherein the ejected stream of droplets is charged by high voltage corona discharge. 8. The method of claim 4, wherein the charging of the ejected stream of droplets attracts the droplets to the eye. 9. The method of claim 1, wherein the ejected stream of droplets are generated to deliver the dose of fluid to the eye between blinks of the eye. 10. The method of claim 1, further comprising warming the fluid to a predefined temperature before generating the ejected stream of droplets. 11. The method of claim 1, further comprising aligning the droplet generating device so that the ejected stream of droplets are directed toward the eye during delivery of the ejected stream of droplets to the eye. 12. The method of claim 11, wherein the aligning is carried out by visual alignment. 13. The method of claim 11, wherein the aligning is carried out with the device including an light emitting diode (LED) to help the subject align the device. 14. A piezoelectric actuated droplet generating device for delivering a fluid to a target as an ejected stream of droplets, the device comprising: a housing; a reservoir disposed within the housing for receiving a volume of fluid; and an ejector mechanism comprising an ejector plate coupled to a fluid delivery area of the reservoir, the ejector plate including a plurality of openings formed through its thickness; and a piezoelectric actuator coupled to the ejector plate, the actuator being operable to oscillate the ejector plate at a frequency to thereby generate the ejected stream of droplets; wherein the ejector mechanism is configured to eject the ejected stream of droplets having an average ejected droplet diameter greater than 20 microns and an average initial droplet ejecting velocity between 2 m/s and 20 m/s such that at least 85% of the mass of the ejected stream of droplets deposit on a target during use. 15. The device of claim 14, wherein the ejector mechanism is configured to eject the ejected stream of droplets having an average ejected droplet diameter in the range of 20 to 100 microns.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (297)
Papania, Mark J.; Barry, James J.; Bagley, Mark C.; Elkouh, Nabil A.; Knaus, Darin; Trabka, Robert, Aerosol delivery systems and methods.
Rodriguez Lorenzo,ITX ; Cini Maurizio,ITX ; Cavallari Cristina,ITX ; Motta Giuseppe,ITX, Apparatus and method for preparing solid forms with controlled release of the active ingredient.
Newcombe Guy Charles Fernley,GBX ; Humberstone Victor Carey,GBX ; Gardner Keith,GBX ; Taylor Peter John,GBX, Apparatus for generating droplets of fluid.
Coleman D. Jackson (223 Maple St. Haworth NJ 07641) Trokel Stephen L. (1192 Park Ave. New York NY 10028), Apparatus for medicinally spraying an eyeball.
Droege,Curtis R.; Gibson,Bruce; Norasak,Sam; Trebolo,Ann M.; Ubellacker,Kent L.; Anderson,Frank E.; Chalin,Adam N., Bridging wick and method for an inkjet printhead.
Kenley Gregory (Northboro MA) Ericson George (Schrewsbury MA) Fortier Richard (Acton MA) Holland Chuck (Northboro MA) Mastors Robert (Ayer MA) Pownell James (Natick MA) Taylor Tracy (Upton MA) Wallac, Digital data storage system with improved data migration.
Hudgins J. S. (321 Harbor Pointe Dr. ; #14 Mt. Pleasant SC 29464), Drop dispenser which automatically stirs the contents of the dispenser when the cap is removed.
Wuchinich David G. (New York NY) Brendolan Robert (Mamaroneck NY) Katz Louis (Flushing NY) Krawitt Donald R. (Rhinebeck NY), Endoscopic ultrasonic aspirators.
Hutson Clifford L. (4440 J Shadow Hills Cir. Santa Barbara CA 93105) Demangus Robert (1715 N. Pacific Ave. Glendale CA 91202-1108), Eye spray mist dispenser.
Humberstone Victor C. (Cambridge GBX) Newcombe Guy C. F. (Cambridge GBX) Sant Andrew J. (Cambridge GBX) Palmer Mathew R. (Cambridge GBX), Fluid droplets production apparatus and method.
Robert A. Casper ; Frank A. Leith ; David L. Gardner ; John Medlin Snow ; Zachary Wood Lyon, Inhalation actuated device for use with metered dose inhalers (MDIS).
van der Linden Klaus (Kronach DEX) Friedrich Juergen (Neuensorg DEX) Zierenberg Bernd (Bingen DEX), Inhalator device, in particular a pocket inhalator.
Davis Jeffrey P. (Madison WI) Archibald Roy D. (Fremont CA) Nicholas Christa D. (Alameda CA) Chandrasekaran Santosh K. (Moraga CA), Liquid droplet dispensing apparatus.
Frederick H. Martin ; Thomas A. Helf ; David J. Schram ; Maryann Jashinske ; David A. Tomkins ; Edward J. Martens, III, Method and apparatus for maintaining control of liquid flow in a vibratory atomizing device.
Poniatowski, John Eugene; Poniatowski, Susan Elizabeth; Walkinshaw, John William, Method and apparatus for the generation of ultrasonic energy fields within circular structures containing a liquid.
Tomei L. David (Dublin OH) Cornhill Fred (Worthington OH) Jagadeesh Jogikal (Columbus OH) Boninger Michael (Columbus OH), Method and apparatus for the measurement of low-level laser-induced fluorescence.
Petterson Tor (31248 Palos Verdes Drive West Palos Verdes Penn. CA 90274), Method of, and dispenser for introducing an opthalmic product into the occular cavity.
Xu, Baomin; Buhler, Steven A.; Welsberg, Michael C.; Wong, William S.; Solberg, Scott E.; Littau, Karl A.; Fitch, John S.; Elrod, Scott A., Methods to make piezoelectric ceramic thick film array and single elements with a reusable single layer substrate structure.
Nakai Hideharu (Nagaokakyo JPX) Kai Isao (Kameoka JPX) Yamamoto Hirohito (Kyoto JPX), Nebulization control system for a piezoelectric ultrasonic nebulizer.
Jonathan K. Embleton GB; Stephen P. Jones GB; Richard J. Malcolmson GB; Luigi G. Martini GB; Peter J. Houzego GB; Sarah A. Rocca GB; Howard N. Stevens GB, Ocular treatment device.
Collins, Jr., James F.; Jobin, Michael Joseph; Tee, Alexander Kirby; Betterley, Carl William; Gant, Evan Isaac Timerding; Williams, Matthew Ian, Ophthalmic misting device.
Burgin Kermit H. (R.R. #1 ; Box 334 Whitestown IN 46075) Newman George R. (2330 Sykes Creek Pkwy. Merritt Island FL 32952), Pillow construction and medication dispenser.
Vlasich Richard J. (Fort Worth TX), Preassembled unit dose dispenser having a compressible container and a tube prefilled with a unit dose of opthalmic gel..
McKenna William J. (Barrington IL) Silvers Kenneth W. (Frankfort IL) Nickerson Rand B. (Scarborough CAX) Welsh Russell J. (Toronto NJ CAX) Walker Harold R. (Edison NJ) Cullity Joseph A. (Jersey City , Television and market research data collection system and method.
Burwell Donald E. (Wethersfield CT) Yanosy James L. (Granby CT) Coates Glen R. (Suffield CT) O\Coin James R. (Windsor Locks CT), Ultrasonic generation of a submicron aerosol mist.
Drews Wolf-Dietrich (Lichtenfels DEX) Van Der Linden Klaus (Kronach DEX) Rttel Martin (Grub a. Forst DEX) Friedrich Jrgen (Neuensorg DEX), Ultrasonic pocket atomizer.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.