Agent for inhibiting odor of pyrazine derivatives
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/121
A61K-031/603
A61K-031/045
A61K-031/05
A61K-031/11
A61K-031/12
A61K-031/09
A61K-031/365
A61K-031/122
A61K-031/075
C07D-241/12
출원번호
US-0960756
(2015-12-07)
등록번호
US-10159655
(2018-12-25)
발명자
/ 주소
Kato, Aya
Saito, Naoko
Inoue, Michiaki
Nomizu, Kayoko
출원인 / 주소
KAO Corporation
대리인 / 주소
Frost Brown Todd, LLC
인용정보
피인용 횟수 :
0인용 특허 :
14
초록
Provided is an agent for reducing odors of pyrazine derivatives based on an olfactory receptor antagonism. The agent for reducing odors of pyrazine derivatives includes at least one antagonist of olfactory receptor OR5K1 as an active ingredient.
대표청구항▼
1. A method of reducing an odor of a pyrazine derivative having the formula (I), wherein R1 represents methyl, ethyl, or acetyl; and R2, R3, and R4 each independently represent hydrogen or methyl,wherein the method comprises providing the pyrazine derivative and providing at least one compound selec
1. A method of reducing an odor of a pyrazine derivative having the formula (I), wherein R1 represents methyl, ethyl, or acetyl; and R2, R3, and R4 each independently represent hydrogen or methyl,wherein the method comprises providing the pyrazine derivative and providing at least one compound selected from the group consisting of the following compounds:2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-oland 4-methyl-3-decen-5-ol; wherein said compound antagonizes the response of olfactory receptor OR5K1 to the pyrazine derivative. 2. The method according to claim 1, which comprises applying at least one compound to an individual in need of reduction of the odor of the pyrazine derivative, in the presence of the odor of the pyrazine derivative. 3. The method according to claim 2, wherein the at least one compound inhibits responses of an olfactory receptor OR5K1. 4. The method according to claim 1, wherein at least one of R1, R2, R3 and R4 is as follows: R1 is methyl or ethyl; R2, R3 and R4 each independently represent methyl. 5. The method according to claim 1, wherein the pyrazine derivative is selected from the group consisting of 2,6-dimethylpyrazine, 2,5-dimethylpyrazine, 2,3-dimethylpyrazine, 2,3,5-trimethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2-monomethylpyrazine, 2-monoethylpyrazine, 2-ethyl-6-methylpyrazine, 3-methyl-2-acetylpyrazine, and 3,5-dimethyl-2-acetylpyrazine. 6. A method of antagonizing responses of an olfactory receptor OR5K1, wherein the method includes applying, to an olfactory receptor OR5K1, at least one compound selected from the group consisting of the following compounds: 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol;and4-methyl-3-decen-5-ol. 7. The method according to claim 1, wherein the pyrazine derivative is 2,6-dimethylpyrazine.
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