A composition may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. Such a composition may further include a plurality of polymeric electrospun fiber fragment clusters. A kit may comprise a first component of a plurality o
A composition may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. Such a composition may further include a plurality of polymeric electrospun fiber fragment clusters. A kit may comprise a first component of a plurality of polymeric electrospun fiber fragments, and a second component of a carrier medium comprising an effective amount of chitosan. A method of treatment may comprise injecting into a portion of a body a composition which may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. The treatment may be directed to one or more of joint inflammation, osteoarthritis, a tissue injury, a muscle tear, a ligament tear, a tendon tear, a void, incontinence, an aneurysm, and a tumor.
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1. A composition comprising: a plurality of synthetic polymeric electrospun fiber fragments; andan aqueous carrier medium comprising an effective amount of chitosan;wherein the plurality of synthetic polymeric electrospun fiber fragments are present in an amount from about 1 fragment per mm3 to abou
1. A composition comprising: a plurality of synthetic polymeric electrospun fiber fragments; andan aqueous carrier medium comprising an effective amount of chitosan;wherein the plurality of synthetic polymeric electrospun fiber fragments are present in an amount from about 1 fragment per mm3 to about 100,000 fragments per mm3; andwherein the effective amount of chitosan to the aqueous carrier medium is from about 0.0001 wt % to about 5 wt %. 2. The composition of claim 1, further comprising a plurality of synthetic polymeric electrospun fiber fragment clusters. 3. The composition of claim 2, wherein the plurality of synthetic polymeric electrospun fiber fragment clusters have, independently, an average length of about 1 μm to about 1000 μm, an average width of about 1 μm to about 1000 μm, and an average height of about 1 μm to about 1000 μm. 4. The composition of claim 2, wherein a weight percent of the plurality of synthetic polymeric electrospun fiber fragments and the plurality of synthetic polymeric electrospun fiber fragment clusters to the aqueous carrier medium is about 0.0001 wt % to about 10 wt %. 5. The composition of claim 1, wherein the plurality of synthetic polymeric electrospun fiber fragments have, independently, an average length of about 1 μm to about 1000 μm, and an average diameter of about 0.1 μm to about 10 μm. 6. The composition of claim 1, further comprising at least one biological cell selected from the group consisting of an autologous cell, a syngeneic cell, an allogeneic cell, a differentiated cell, a stem cell, a multipotent stem cell, a pluripotent stem cell, an induced pluripotent stem cell, a totipotent stem cell, a bone marrow-derived stem cell, a cord blood stem cell, a mesenchymal cell, an embryonic stem cell, platelet-rich plasma, stromal vascular fraction, and combinations thereof. 7. A kit comprising: a first component comprising a plurality of synthetic polymeric electrospun fiber fragments; anda second component comprising an aqueous carrier medium comprising an effective amount of chitosan;wherein the plurality of synthetic polymeric electrospun fiber fragments are present in an amount from about 1 fragment per mm3 to about 100,000 fragments per mm3; andwherein the effective amount of chitosan to the aqueous carrier medium is from about 0.0001 wt % to about 5 wt %. 8. The kit of claim 7, wherein the first component further comprises a plurality of synthetic polymeric electrospun fiber fragment clusters. 9. A method of treatment comprising injecting, into a portion of a body, the composition of claim 1. 10. The method of claim 9, wherein the composition further comprises a plurality of synthetic polymeric electrospun fiber fragment clusters. 11. The method of claim 9, wherein the portion of the body comprises one or more of a portion of cartilage, a meniscus, a ligament, a tendon, a joint, a muscle, a portion of skin, a sphincter, and a blood vessel.
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