Composition comprising chitosan and a fungicide
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-031/16
A01N-043/16
A01N-063/02
C05F-001/00
C05F-011/00
C05G-003/02
A01N-043/36
A01N-043/40
A01N-043/54
A01N-043/56
출원번호
US-0437530
(2013-10-22)
등록번호
US-10172353
(2019-01-08)
우선권정보
GB-1218954.4 (2012-10-22)
국제출원번호
PCT/EP2013/072099
(2013-10-22)
국제공개번호
WO2014/064119
(2014-05-01)
발명자
/ 주소
Tronsmo, Arne
Aam, Berit Bjugan
Hjeljord, Linda
Sorlie, Morten
Rahman, Md Hafizur
Norberg, Anne Line
Eijsink, Vincent
출원인 / 주소
BIOCHOS AS
대리인 / 주소
Wenderoth, Lind & Ponack, L.L.P.
인용정보
피인용 횟수 :
0인용 특허 :
3
초록▼
The present invention provides a composition comprising (i) chitosan or chitopoly- or chitooligo-saccharides thereof, wherein said chitosan or chitopoly- or chitooligo-saccharides thereof comprise β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine monomers and have a degree of acetylation betwe
The present invention provides a composition comprising (i) chitosan or chitopoly- or chitooligo-saccharides thereof, wherein said chitosan or chitopoly- or chitooligo-saccharides thereof comprise β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine monomers and have a degree of acetylation between 0.05 and 0.20 and an average degree of polymerization ≤250 (molecular weight ≤42,000 Da), and (ii) a fungicide not containing chitopoly- or chitooligo-saccharides.
대표청구항▼
1. A composition comprising (i) chitooligo-saccharides, wherein said chitooligo-saccharides comprise β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine monomers and have a degree of acetylation between 0.01 and 0.40 and an average degree of polymerization of 20-60 as assessed by measurement wit
1. A composition comprising (i) chitooligo-saccharides, wherein said chitooligo-saccharides comprise β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine monomers and have a degree of acetylation between 0.01 and 0.40 and an average degree of polymerization of 20-60 as assessed by measurement with 1H NMR spectroscopy, and(ii) a fungicide not containing chitopoly- or chitooligo-saccharides;wherein said fungicide is not an inorganic fungicide;wherein the fungicidal activity of said chitooligo-saccharides and said fungicide is synergistic;wherein the chitooligo-saccharides are present in the composition at a concentration of 1-1000 μg/ml;wherein the chitooligo-saccharides and said fungicide are present in a ratio of 1000:1 to 1:2 (w/v); andwherein the fungicide is selected from the group consisting of an anilide fungicide; an anilinopyrimidine fungicide; a pyrrole fungicide; a methoxyacrylate strobilurin fungicide; a carbanilate fungicide; a pyrazole fungicide; a pyridine fungicide; a methoxycarbanilate strobilurin fungicide, a naphthoquinone fungicide, a benzamide fungicide, a strobilurin fungicide, a conazole fungicide, a carboxamide fungicide, a triazole fungicide, and a dicarboximide fungicide, and combinations thereof. 2. The composition as claimed in claim 1 having an average degree of polymerization (DPn) of between 20 to 40. 3. The composition as claimed in claim 1 wherein the DPn is 23, 30, or 40. 4. The composition as claimed in claim 1 wherein ≥50% of the polymer chains in the chitooligo-saccharides have a D-glucosamine sugar unit at their reducing ends. 5. The composition as claimed in claim 1 where said chitooligo-saccharides are prepared by acid hydrolysis. 6. The composition as claimed in claim 1 where said chitooligo-saccharides are prepared by a method comprising dissolving chitosan in water or a weak acidic solution followed by enzymatic cleavage using an enzyme capable of catalysing degradation of chitosan into chitooligo-saccharides. 7. The composition as claimed in claim 5 wherein the resultant chitooligo-saccharide product mix is separated by size exclusion chromatography. 8. The composition as claimed in claim 1 wherein the chitooligo-saccharides are present in the composition at a concentration between 10 and 1000 μg/ml. 9. The composition as claimed in claim 1 wherein the fungicide is selected from the group consisting of fenhexamid, cyprodinil, fludioxonil, azoxystrobin, boscalid, pyraclostrobin and dithianon, and combinations thereof. 10. The composition as claimed in claim 1 wherein at least 2 fungicides not containing chitopoly- or chitooligo-saccharides are present. 11. The composition as claimed in claim 1 wherein the fungicide is present in the composition at a suboptimal concentration. 12. The composition as claimed in claim 11 wherein the concentration of the fungicide in the composition is 1-20% of the optimal concentration of the fungicide. 13. The composition as claimed in claim 1 wherein the fungicide is selected from (i) fenhexamid; (ii) cyprodinil and fludioxonil; (iii) azoxystrobin; (iv) boscalid and pyraclostrobin and (v) dithianon and the chitooligo-saccharides have a DPn of between 20 and 60. 14. A kit comprising (i) chitooligo-saccharides and (ii) a fungicide, wherein each component is as defined in claim 1. 15. A method for treating fungal disease, damage or infection in a plant caused by a fungus, comprising contacting the plant or part thereof which is affected by the fungus with an effective amount of the composition of claim 1. 16. The method as claimed in claim 15 wherein the method is carried out on plants and the fungus is selected from Botrytis cineria, Alternaria brassicicola, Mucor piriformis, Microdochium sp and Venturia inaequalis. 17. The method as claimed in claim 15 wherein the plant is a cereal, turf grass, rice, grape or root, tuber, fruit, berry, vegetable or pulse crop plant. 18. A method for treating fungal disease, damage or infection in a plant caused by a fungus comprising contacting the plant or part thereof which is affected by the fungus with an effective amount of the composition of claim 13. 19. The composition of claim 1 wherein said chitooligo-saccharides have a degree of acetylation between 0.05 and 0.20. 20. The composition of claim 2 having an average degree of polymerization (DPn) of between 20 to 35. 21. The composition of claim 12 wherein the concentration of the fungicide in the composition is <10% of the optimal concentration. 22. The composition of claim 13 wherein the chitooligo-saccharides have a DPn of 20 to 40. 23. The composition of claim 13 wherein the chitooligo-saccharides have a DPn of 20 to 35. 24. The composition of claim 13 wherein the chitooligo-saccharides have a DPn of 23, 30, or 37.
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이 특허에 인용된 특허 (3)
Williamson John B. ; Schulteis David, Basal and chitinase broth compositions for enhancing anti-fungal activity of a chemical fungicide and methods for prep.
Ito Kazuhiro (Handa JPX) Entani Etsuzo (Handa JPX) Kawamura Yoshiya (Kounan JPX), Methods for protecting vegetables, turfgrass, rice and fruit trees from fungi and bacteria.
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