Bone implant compositions and methods are provide that have a first surface and a second surface, the first surface and the second surface comprising a demineralized bone matrix and having a plurality of perforations configured to receive demineralized bone; and a third surface of the bone implant c
Bone implant compositions and methods are provide that have a first surface and a second surface, the first surface and the second surface comprising a demineralized bone matrix and having a plurality of perforations configured to receive demineralized bone; and a third surface of the bone implant comprising cortical bone, the third surface disposed between the first surface and the second surface. The bone implant compositions and methods provided are osteoinductive and allow rapid bone fusion.
대표청구항▼
1. A bone implant comprising a first surface and a second surface comprising a demineralized bone matrix, the first surface and the second surface comprising a plurality of perforations configured to receive a bone material and to increase the surface area of the bone implant; and a third surface fa
1. A bone implant comprising a first surface and a second surface comprising a demineralized bone matrix, the first surface and the second surface comprising a plurality of perforations configured to receive a bone material and to increase the surface area of the bone implant; and a third surface facing the same direction as the first surface and the second surface of the bone implant comprising nondemineralized cortical bone, wherein the third surface is disposed between the first surface and the second surface, and the bone implant comprises a top surface and a bottom surface, the perforations extending from the top surface, through the demineralized bone matrix, to the bottom surface to provide channels between the top and the bottom surfaces; and the third surface of the nondemineralized cortical bone does not contain any perforations, wherein the top and the bottom surfaces comprise the first, the second and the third surfaces. 2. A bone implant according to claim 1, wherein the first surface defines a first wing and the second surface defines a second wing. 3. A bone implant according to claim 2, wherein the first wing and the second wing have a concave configuration at the third surface. 4. A bone implant according to claim 1, wherein the perforations comprise (i) a coating of demineralized matrix material disposed therein; (ii) demineralized bone powder or demineralized bone fibers as the demineralized bone matrix material; or (iii) a solid demineralized plug or insert disposed in the perforations. 5. A bone implant according to claim 1, wherein the perforations comprise side walls each of which is surface demineralized. 6. A bone implant according to claim 5, wherein the perforations are partially filled with demineralized bone powder, demineralized bone fibers, demineralized bone plugs, or demineralized bone inserts. 7. A bone implant according to claim 5, wherein the plurality of perforations are spaced in a configuration to contact adjacent bone surfaces when the bone implant is implanted into a bone defect of a patient. 8. A bone implant according to claim 1, wherein the first surface and the second surface are coated with demineralized bone matrix material. 9. A bone implant according to claim 8, wherein (i) a depth of the demineralized region varies along the first surface and the second surface; (ii) the first surface and the second surface of the bone implant is demineralized so as to avoid subsidence when the bone implant is implanted into a facet joint of a patient; or (iii) the demineralized bone coating binds to the bone implant by air drying, freeze drying, heat drying, or by using a chemical cross-linking agent. 10. An allograft configured for disposal in a facet joint defect, the allograft comprising a first surface and a second surface, the first surface and the second surface comprising a demineralized bone matrix material and comprising a plurality of perforations having demineralized bone disposed therein; and a third surface facing the same direction as the first surface and the second surface of the allograft comprising nondemineralized cortical bone, wherein the third surface is disposed between the first surface and the second surface, and the allograft comprises a top surface and a bottom surface, the perforations extending from the top surface, through the demineralized bone matrix, to the bottom surface to provide channels between the top and the bottom surfaces; and the third surface of the nondemineralized cortical bone does not contain any perforations, wherein the top and the bottom surfaces comprise the first, the second and the third surfaces. 11. An allograft according to claim 10, wherein the perforations comprise a coating of demineralized bone powder, demineralized bone fibers, or a demineralized plug, or a demineralized insert. 12. An allograft according to claim 10, wherein the perforations comprise side walls each of which is surface demineralized. 13. An allograft according to claim 10, wherein the perforations are spaced in a configuration to contact adjacent bone surfaces when the allograft is implanted into the facet joint of a patient.
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