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The invention generally provides a static back pressure regulator. In exemplary embodiments, the static back pressure regulator includes a seat that defines part of a fluid pathway, a poppet, a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway, and a

The invention generally provides a static back pressure regulator. In exemplary embodiments, the static back pressure regulator includes a seat that defines part of a fluid pathway, a poppet, a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway, and a calibration element configured to adjust a force applied to the poppet by the spring. The calibration element can include a through hole that forms part of the fluid pathway. The poppet can include a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat.

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1. A fluid control system comprising: a fluid chromatography system, the fluid chromatography system comprising: a static back pressure regulator comprising: a main housing defining part of a fluid pathway;a retaining nut; anda cartridge disposed within a cavity that is defined by the main housing a

1. A fluid control system comprising: a fluid chromatography system, the fluid chromatography system comprising: a static back pressure regulator comprising: a main housing defining part of a fluid pathway;a retaining nut; anda cartridge disposed within a cavity that is defined by the main housing and the retaining nut, the cartridge including, a seat disposed in a recess of the cartridge and defining part of the fluid pathway;a poppet;a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway extending through the cartridge; anda calibration element threadingly received within an inner cartridge housing and configured to move relative to the inner cartridge housing to adjust a force applied to the poppet by the spring, wherein the calibration element includes a through hole that forms part of the fluid pathway,wherein the poppet comprises a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat, andwherein the main housing is configured to receive liquid CO2 from an inlet port disposed within the main housing, andwherein the poppet includes a conical portion that contacts the seat and has an included angle greater or equal to 20 degrees and less than or equal to 60 degrees. 2. The static back pressure regulator of claim 1, wherein the poppet further comprises a second guiding portion that extends into the spring and thereby inhibits buckling of the spring. 3. The static back pressure regulator of claim 1, further comprising a damping member arranged to absorb energy and inhibit vibration of the poppet. 4. The static back pressure regulator of claim 3, wherein the poppet is disposed within the cavity, and wherein the damping member is disposed between the calibration element and the poppet. 5. The static back pressure regulator of claim 4, wherein the damping member comprises an o-ring gasket. 6. The static back pressure regulator of claim 3, wherein the damping member is formed of an elastomer. 7. The static back pressure regulator of claim 3, wherein the damping member is disposed between the calibration element and the first guiding portion of the poppet. 8. The static back pressure regulator of claim 1, wherein the poppet has a flow channel defined by a planar flat extending along a side of the poppet so as to cause a biasing of the poppet, as fluid flows through the fluid pathway, such that vibration of the poppet is inhibited. 9. The static back pressure regulator of claim 1, wherein the poppet is disposed within the cavity, and wherein the cartridge has helical grooves along the cavity to cause a vortex around the poppet, as fluid flows through the fluid pathway, such that vibration of the poppet is inhibited. 10. The static back pressure regulator of claim 1, wherein the poppet comprises: a tip; anda stem comprising the first guiding portion. 11. The static back pressure regulator of claim 10, wherein the stem defines a tip recess for receiving the tip. 12. The static back pressure regulator of claim 10, wherein the stem is integral with the tip. 13. The static back pressure regulator of claim 10, wherein the tip is at least partially formed of a chemically resistant ceramic. 14. The static back pressure regulator of claim 13, wherein the chemically resistant ceramic is selected from the group consisting of zirconia, ruby, and sapphire. 15. The static back pressure regulator of claim 1, wherein the poppet comprises a metal plating. 16. The static back pressure regulator of claim 15, wherein the metal plating is selected from the group consisting of a gold plating and a platinum plating. 17. The static back pressure regulator of claim 1, wherein the seat is at least partially formed of a polymer. 18. The static back pressure regulator of claim 17, wherein the polymer is selected from the group consisting of polyimide and polyether-ether-ketone. 19. The static back pressure regulator of claim 1, further comprising a protrusion that extends from an end of the calibration element into the spring such that the protrusion is disposed between the poppet and the spring. 20. The static back pressure regulator of claim 1, wherein the first guiding portion of the poppet extends into the through hole when the poppet is in a proximal-most position relative to the calibration element and when the poppet is translated distally relative to the calibration element. 21. The static back pressure regulator of claim 1, wherein the spring exerts sufficient force to allow the static back pressure regulator to regulate pressures of at least 1100 psi. 22. A fluid control system comprising: a fluid chromatography system, the fluid chromatography system comprising: a static back pressure regulator comprising: a main housing defining part of a fluid pathway;a retaining nut; anda cartridge disposed within a cavity that is defined by the main housing and the retaining nut, the cartridge including, a seat disposed in a recess of the cartridge and defining part of the fluid pathway;a poppet;a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway extending through the cartridge; anda calibration element threadingly received within an inner cartridge housing and configured to move relative to the inner cartridge housing to adjust a force applied to the poppet by the spring,wherein the calibration element includes a through hole that forms part of the fluid pathway,wherein the poppet comprises a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat, andwherein the main housing is configured to receive liquid CO2 from an inlet port disposed within the main housing,wherein the poppet further comprises a tip, and wherein the tip is at least partially formed of a material selected from the group consisting of zirconia, ruby, and sapphire. 23. A fluid control system comprising: a fluid chromatography system, the fluid chromatography system comprising: a static back pressure regulator comprising: a main housing defining part of a fluid pathway;a retaining nut; anda cartridge disposed within a cavity that is defined by the main housing and the retaining nut, the cartridge including, a seat disposed in a recess of the cartridge and defining part of the fluid pathway;a poppet;a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway extending through the cartridge; anda calibration element threadingly received within an inner cartridge housing and configured to move relative to the inner cartridge housing to adjust a force applied to the poppet by the spring, wherein the calibration element includes a through hole that forms part of the fluid pathway,wherein the poppet comprises a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat, andwherein the main housing is configured to receive liquid CO2 from an inlet port disposed within the main housing,wherein the poppet further comprises a metal plating, and wherein the metal plating is selected from the group consisting of a gold plating and a platinum plating. 24. A fluid control system comprising: a fluid chromatography system, the fluid chromatography system including a plurality of supercritical fluid chromatography manager modules, at least one of the plurality of supercritical fluid chromatography manager modules including a static back pressure regulator, the static back pressure regulator comprising: a main housing defining part of a fluid pathway;a retaining nut; anda cartridge disposed within a cavity that is defined by the main housing and the retaining nut, the cartridge including, a seat disposed in a recess of the cartridge and defining part of the fluid pathway;a poppet;a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway extending through the cartridge; anda calibration element threadingly received within an inner cartridge housing and configured to move relative to the inner cartridge housing to adjust a force applied to the poppet by the spring, wherein the calibration element includes a through hole that forms part of the fluid pathway,wherein the poppet comprises a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat, andwherein the main housing is configured to receive liquid CO2 from an inlet port disposed within the main housing. 25. A static back pressure regulator comprising: a main housing defining part of a fluid pathway;a retaining nut; anda cartridge disposed within a cavity that is defined by the main housing and the retaining nut, the cartridge including, a seat disposed in a recess of the cartridge and defining part of the fluid pathway;a poppet;a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway extending through the cartridge; anda calibration element threadingly received within an inner cartridge housing and configured to move relative to the inner cartridge housing to adjust a force applied to the poppet by the spring, wherein the calibration element includes a through hole that forms part of the fluid pathway,wherein the poppet comprises a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat, andwherein the main housing is configured to receive liquid CO2 from an inlet port disposed within the main housing,wherein the poppet has a flow channel defined by a planar flat extending along a side of the poppet so as to cause a biasing of the poppet, as fluid flows through the fluid pathway, such that vibration of the poppet is inhibited.