Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
H01L-031/062
H01L-021/30
H01L-027/146
A61B-001/05
A61B-005/01
A61B-005/03
A61B-005/053
A61B-008/12
A61B-018/14
A61B-018/18
A61B-018/20
A61N-007/02
A61B-005/00
A61B-005/0408
A61B-018/24
A61B-018/00
A61B-018/02
출원번호
US-0498941
(2017-04-27)
등록번호
US-10186546
(2019-01-22)
발명자
/ 주소
De Graff, Bassel
Ghaffari, Roozbeh
Arora, William J.
출원인 / 주소
MC10, Inc.
대리인 / 주소
Nixon Peabody LLP
인용정보
피인용 횟수 :
0인용 특허 :
129
초록▼
System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen,
System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy. Further, the invention enables the incorporation of both sensing and therapeutic devices on the same substrate allowing for faster treatment of diseased tissue and fewer devices to perform the same procedure.
대표청구항▼
1. An apparatus for detecting and measuring aspects of a tissue of a body of a subject, comprising: expandable substrate;stretchable circuitry disposed on said substrate and configured to remain functional upon conforming to a surface of said tissue, said circuitry comprising: sensing devices config
1. An apparatus for detecting and measuring aspects of a tissue of a body of a subject, comprising: expandable substrate;stretchable circuitry disposed on said substrate and configured to remain functional upon conforming to a surface of said tissue, said circuitry comprising: sensing devices configured to detect data indicative of a parameter of said tissue upon said circuitry being in conformal contact with said tissue, andan array of imaging devices configured to generate visual data;a processing facility in electronic communication with said circuitry and configured to receive said data indicative of said parameter of said tissue and said visual data; andan output facility in electronic communication with said processing facility,wherein said processing facility is configured to (i) use said data indicative of said parameter of said tissue and said visual data to generate output data, and (ii) cause said output facility to display said output data. 2. The apparatus of claim 1, wherein the sensing devices include a thermistor, a thermocouple, a silicon band gap temperature sensor, a thin-film resistance temperature sensor, a photodetector, a piezoelectric sensor, an ultrasonic sensor, or an ion sensitive field effect transistor, or combinations thereof. 3. The apparatus of claim 1, wherein the processing facility is configured to activate the circuitry to commence with detecting the data indicative of the parameter in response to one or more pressure measurements from one or more of the sensing devices satisfying a threshold value. 4. The apparatus of claim 1, wherein the parameter is a thermal parameter, an optical parameter, an electrochemical parameter, a biochemical parameter, an electrical parameter, or a mechanical parameter. 5. The apparatus of claim 1, wherein the circuitry further comprises a receiver circuit and a transmitter circuit which are configured to receive and transmit signals, respectively, in a wireless mode. 6. The apparatus of claim 1, wherein the circuitry further comprises an inductive coupling transceiver comprising an inductor-based receiver and transmitter coil. 7. The apparatus of claim 1, wherein the sensing devices include a plurality of contact sensors arranged in an array on the expandable substrate. 8. The apparatus of claim 1, wherein the circuitry further comprises one or more light sources configured to illuminate the tissue, and the array of imaging devices are configured to generate the visual data based on light generated by the one or more light sources reflected from the tissue. 9. The apparatus of claim 8, wherein the one or more light sources are one or more LEDs. 10. The apparatus of claim 1, wherein the expandable substrate includes a conformal sheet that is adapted to wrap conformally on a portion of the tissue of the body of the subject. 11. The apparatus of claim 10, wherein at least one of the sensing devices comprises electrodes configured to receive electrocardiography signals, and the expandable substrate and the stretchable circuitry form an ECG monitor. 12. The apparatus of claim 1, wherein the sensing devices include one or more contact sensors that generate data indicating contact with the tissue. 13. The apparatus of claim 12, wherein the data indicating contact indicates an area of the contact. 14. The apparatus of claim 1, wherein the circuitry further comprises one or more elements configured to effect a desired therapy. 15. The apparatus of claim 14, wherein the one or more elements are configured to deliver coolant, the apparatus further comprising a catheter delivery system configured to provide the coolant to the one or more elements. 16. The apparatus of claim 14, wherein the one or more elements comprises one or more LEDs arranged in an array, and the one or more LEDs are configured to deliver photo therapy to photoactive neurons in the tissue. 17. The apparatus of claim 14, wherein the one or more elements comprise one or more electrodes configured to deliver ablative therapy. 18. The apparatus of claim 14, wherein the one or more elements comprise heat or light-emitting electronics configured to activate a drug-delivery polymer. 19. The apparatus of claim 18, wherein the light-emitting electronics comprise LEDs configured to cause a de-polymerization reaction within the drug-delivery polymer for releasing one or more drugs.
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