Compositions for inhibition of insect sensing
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-043/653
A01N-043/78
A01N-043/90
A01N-043/82
A01N-053/00
A01N-047/16
A01N-047/18
C07D-491/052
C07D-401/14
C07D-409/14
C07D-405/14
C07D-513/04
A01N-025/08
C07D-249/12
C07D-401/04
C07D-403/04
C07D-405/04
C07D-405/06
C07D-409/04
C07D-413/14
C07D-471/04
C07D-491/048
C07D-491/056
출원번호
US-0443340
(2017-02-27)
등록번호
US-10188105
(2019-01-29)
발명자
/ 주소
Zwiebel, Laurence
Pask, Gregory M.
Rinker, David C.
Romaine, Ian M.
Sulikowski, Gary A.
Reid, Paul R.
Waterson, Alex G.
Kim, Kwangho
Jones, Patrick L.
Taylor, Robert W.
출원인 / 주소
Vanderbilt University
대리인 / 주소
Ballard Spahr LLP
인용정보
피인용 횟수 :
0인용 특허 :
33
초록▼
In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Method of employing such agents, and articles incorporat
In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
대표청구항▼
1. A compound, or salt thereof, having a formula: whereinR1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1 is taken together with R2 to be optionally substituted (C1-C4) alkan
1. A compound, or salt thereof, having a formula: whereinR1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1 is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR2 is hydrogen,or R2 is taken together with R1 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR3 is optionally substituted (C1-C5) alkyl or optionally substituted (C1-C5) alkenyl; andR4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkenyl; andR5 is optionally substituted aryl or optionally substituted (≤C6) heteroaryl; andR6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl,wherein the compound is not 2. The compound of claim 1, wherein R1, R2, and R6 are hydrogen; wherein R4 is (C1-C5) alkyl or (C1-C5) alkenyl; and wherein R5 is optionally substituted (≤C6) heteroaryl. 3. The compound of claim 1, wherein the compound is represented by the formula: wherein R1 is hydrogen or optionally substituted C1-C4 alkyl; wherein R2 is hydrogen; wherein R4 is optionally substituted (C1-C5) alkyl; and wherein R11 is hydrogen, hydroxy, —F, —CI, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —N(CH3)2, —C(O)NH2, —OC(O)CH3, or —S(O)2NH2. 4. The compound of claim 3, wherein R1 is hydrogen; wherein R2 is hydrogen; wherein R3 is methyl, ethyl, n-propyl, or isopropyl; wherein R4 is ethyl, propyl, or cyclopropyl; and wherein R11 is hydrogen, hydroxy, —F, —CI, —Br, —I, —NH2, or —NO2. 5. The compound of claim 1, wherein the compound is represented by the formula: wherein R11 is —H, —OH, —F, —CI, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —N(CH3)2, —C(O)NH2, —OC(O)CH3, or —S(O)2NH2. 6. The compound of claim 5, wherein R1 is hydrogen; wherein R2 is hydrogen; wherein R3 is methyl, ethyl, n-propyl, or isopropyl; and wherein R11 is hydrogen, hydroxy, —F, —CI, —Br, —I, —NH2, or —NO2. 7. The compound of claim 1, wherein the compound is represented by the formula: wherein R11 is —H, —OH, —F, —CI, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —N(CH3)2, —C(O)NH2, —OC(O)CH3, or —S(O)2NH2. 8. The compound of claim 7, wherein the compound is represented by the formula: 9. The compound of claim 8, wherein R1 is hydrogen; wherein R2 is hydrogen; and wherein R3 is methyl, n-propyl, or isopropyl. 10. The compound of claim 1, wherein the compound is selected from: 11. The compound of claim 1, wherein the compound is selected from: 12. An insect-control composition comprising at least one delivery agent and a compound, or salt thereof, having a formula: whereinR1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1 is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR2 is hydrogen,or R2 is taken together with R1 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR3 is optionally substituted (C1-C5) alkyl or optionally substituted (C1-C5) alkenyl; andR4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkenyl; andR5 is optionally substituted aryl or optionally substituted (≤C6) heteroaryl; andR6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl,wherein the compound is not 13. The composition of claim 12, wherein the agent comprises a water-soluble tablet, an aerosol, a sprayable liquid, a misting system, bait, or a pellet. 14. The composition of claim 12, wherein the delivery agent comprises at least one volatile organic compound. 15. The composition of claim 14, wherein the at least one volatile organic compound is selected from chlorpyrifos, 1,3-dichloropropene, trifuralin, methyl bromide, demthoate, metam-sodium, oxyfluorfen, permethrin, limonene, chloropicrin, bifenthrin, and bensulide. 16. The composition of claim 12, wherein the delivery agent is selected from film-forming agents, ester containing solvents, gelling agents, skin conditioning agents and emollients, antioxidants, structuring agents, emulsifiers, silicone containing compounds, essential oils, thickening agents, and vehicles. 17. The composition of claim 12, wherein the compound is selected from: 18. The composition of claim 12, wherein the compound is selected from: 19. An insect-control article comprising a compound, or salt thereof, having a formula: whereinR1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR2 is hydrogen,or R2 is taken together with R1to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR3 is optionally substituted (C1-C5) alkyl or optionally substituted (C1-C5) alkenyl; andR4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkeny; andR5 is optionally substituted aryl or optionally substituted (≤C6) heteroaryl; andR6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenylwherein the compound is not wherein the compound is coated onto or impregnated into an article selected from netting, clothing, fabric, bedding, tarps, tents, awnings, door flaps, screens, and drapes. 20. The article of claim 19, wherein the compound is selected from: 21. The article of claim 19, wherein the compound is selected from:
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