A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a
A process for forming microspheres is disclosed. The process includes contacting a solvent with a modified cellulose to form a solution; contacting the modified cellulose solution with at least one bioactive agent to form a discontinuous phase liquid; contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and contacting the emulsion with a third phase liquid to extract the solvent from the emulsion, thereby forming a plurality of modified cellulose microspheres.
대표청구항▼
1. A process for forming microspheres comprising: forming a first plurality of microspheres including at least one bioactive agent and oxidized cellulose;contacting the first plurality of microspheres with a solution of an aliphatic polyester to form a discontinuous phase liquid;contacting the disco
1. A process for forming microspheres comprising: forming a first plurality of microspheres including at least one bioactive agent and oxidized cellulose;contacting the first plurality of microspheres with a solution of an aliphatic polyester to form a discontinuous phase liquid;contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; andextracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in the aliphatic polyester. 2. The process according to claim 1, wherein the at least one bioactive agent is selected from the group consisting of a hydrophilic bioactive agent, a protein therapeutic, a biologic, and combinations thereof. 3. The process according to claim 1, wherein the aliphatic polyester is selected from the group consisting of polylactide, polylactide-co-glycolide, polylactide-polycaprolactone, and combinations thereof. 4. The process according to claim 1, wherein the continuous phase liquid includes at least one emulsifier and water. 5. The process according to claim 1, further comprising: contacting the second plurality of microspheres with an oxidized cellulose solution to form a second discontinuous phase liquid;contacting the second discontinuous phase liquid with a second continuous phase liquid to form a second emulsion; andextracting a third plurality of microspheres from the second emulsion, the third plurality of microspheres including one or more microspheres of the second plurality of microspheres at least partially encapsulated in oxidized cellulose. 6. A process for forming microspheres comprising: forming a first plurality of microspheres including an aliphatic polyester;contacting the first plurality of microspheres with an oxidized cellulose solution to form a discontinuous phase liquid;contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; andextracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in oxidized cellulose. 7. The process according to claim 6, wherein at least one of the first plurality of microspheres or the oxidized cellulose solution includes at least one bioactive agent. 8. The process according to claim 7, wherein the at least one bioactive agent is selected from the group consisting of a hydrophilic bioactive agent, a protein therapeutic, a biologic, and combinations thereof. 9. The process according to claim 6, wherein the aliphatic polyester is selected from the group consisting of polylactide, polylactide-co-glycolide, polylactide-polycaprolactone, and combinations thereof. 10. The process according to claim 6, comprising: contacting the second plurality of microspheres with a second solution of a biodegradable polymer to form a second discontinuous phase liquid;contacting the second discontinuous phase liquid with a second continuous phase liquid to form a second emulsion; andextracting a third plurality of microspheres from the second emulsion, the third plurality of microspheres including one or more microspheres of the second plurality of microspheres at least partially encapsulated in the biodegradable polymer of the second solution. 11. A process for forming microspheres comprising: forming a first plurality of microspheres including at least one bioactive agent and oxidized cellulose;contacting the first plurality of microspheres with a solution of a biodegradable polymer to form a discontinuous phase liquid, the biodegradable polymer being different from the oxidized cellulose;contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; andextracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in the biodegradable polymer. 12. The process according to claim 11, wherein the at least one bioactive agent is selected from the group consisting of a hydrophilic bioactive agent, a protein therapeutic, a biologic, and combinations thereof. 13. The process according to claim 12, wherein the biodegradable polymer is an aliphatic polyester. 14. The process according to claim 13, wherein the aliphatic polyester is selected from the group consisting of polylactide, polylactide-co-glycolide, polylactide-polycaprolactone, and combinations thereof. 15. The process according to claim 11, wherein the continuous phase liquid comprises at least one emulsifier and water. 16. The process according to claim 11, further comprising: contacting the second plurality of microspheres with an oxidized cellulose solution to form a second discontinuous phase liquid;contacting the second discontinuous phase liquid with a second continuous phase liquid to form a second emulsion; andextracting a third plurality of microspheres from the second emulsion, the third plurality of microspheres including one or more microspheres of the second plurality of microspheres at least partially encapsulated in oxidized cellulose.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Lerner, E. Itzhak; Rosenberger, Vered; Flashner-Barak, Moshe; Drabkin, Anna; Moldavski, Naomi, Drug microparticles, processes of preparing them and a drug delivery vehicle comprising them.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Implants coated with collagen-polymer conjugates.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Sackler, Richard S.; Goldenheim, Paul D.; Chasin, Mark; Burch, Ronald M.; Reder, Robert F.; Tigner, Joseph, Methods for providing safe local anesthesia.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Figuly, Garret D.; Mahajan, Surbhi; Schiffino, Rinaldo S.; Feldstein, Michael Jordan; Shazly, Tarek Michael; Edelman, Elazer R., Process for embolization using swellable and deformable microspheres.
Turbak Albin F. (Convent Station NJ) El-Kafrawy Adel (Rockaway NJ) Snyder ; Jr. Fred W. (Wharton NJ) Auerbach Andrew B. (Livingston NJ), Process for forming shaped cellulosic product.
McCorsley ; III Clarence C. (Asheville NC) Varga Julianna K. (Asheville NC), Process for making a solid impregnated precursor of a solution of cellulose.
Saferstein Lowell (Edison NJ) Wolf Stephen (Neshanic Station NJ) Kamp Lola (Highland Park NJ) Linsky Cary (East Brunswick NJ) Wiseman David (Highland Park NJ), Process for preparing a neutralized oxidized cellulose product and its method of use.
McCorsley ; III Clarence C. (Asheville NC), Process for shaped cellulose article prepared from a solution containing cellulose dissolved in a tertiary amine N-oxide.
Varga Julianna K. (Asheville NC), Shapeable tertiary amine N-oxide solution of cellulose, shaped cellulose product made therefrom and process for preparin.
McCorsley ; III Clarence C. (Asheville NC), Shaped cellulose article prepared from a solution containing cellulose dissolved in a tertiary amine N-oxide solvent and.
Turbak Albin F. (Convent Station NJ) El-Kafrawy Adel (Rockaway NJ) Snyder ; Jr. Fred W. (Wharton NJ) Auerbach Andrew B. (Livingston NJ), Solvent system for cellulose.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.