A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid f
A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.
대표청구항▼
1. A drug delivery system, comprising: an aerosol generator unit comprising (i) a capillary passage adapted to at least partially volatilize a liquid formulation, the capillary passage having a capillary passage inlet and a capillary passage outlet, (ii) a first heater body operable to heat the capi
1. A drug delivery system, comprising: an aerosol generator unit comprising (i) a capillary passage adapted to at least partially volatilize a liquid formulation, the capillary passage having a capillary passage inlet and a capillary passage outlet, (ii) a first heater body operable to heat the capillary passage to a temperature range effective to at least partially volatilize the liquid formulation in the capillary passage, the capillary passage being fitted within the first heater body, (iii) a second heater body arranged to be remote to the capillary passage and the first heater body, and (iv) at least one gas passage arranged such that gas is heated by the second heater body to produce a heated gas, the at least one gas passage having a gas passage inlet and a gas passage outlet, and wherein the at least one gas passage is separated from the capillary passage and the first heater body;a pumping unit adapted to supply the liquid formulation to the aerosol generator unit;an aerosol confinement member arranged at a distal end of the first heater body and configured to capture aerosols produced by the capillary passage;a flow passage having an inlet end in fluid communication with an outlet of the aerosol confinement member and an outlet end adapted for connection to a patient interface which supplies ventilation to a patient's lungs; andthe aerosol confinement member connecting the capillary passage outlet and the gas passage outlet, wherein the capillary passage outlet is configured to inject the aerosols produced by the capillary passage into the aerosol confinement member and the gas passage outlet is configured to inject the gas heated by the second heater body into the aerosol confinement member, and wherein the aerosol confinement member is arranged to mix the aerosols produced by the capillary passage with the heated gas in a manner that reduces condensation of aerosol to produce a mixed aerosol and operable to direct the mixed aerosol into the inlet end of the flow passage. 2. The drug delivery system of claim 1, wherein the pumping unit includes one syringe pump and a pair of valves operable to supply the liquid formulation into an inlet of the aerosol generator unit. 3. The drug delivery system of claim 1, wherein the pumping unit includes two syringe pumps and a valving arrangement operable to supply the liquid formulation into an inlet of one syringe pump during delivery of the liquid formulation to the aerosol generator unit by the other syringe pump. 4. The drug delivery system of claim 3, wherein the valving arrangement includes an inlet which can be connected to a source of the liquid formulation, first and second flow paths in fluid communication with the inlet of the valving arrangement, an outlet of the valving arrangement in fluid communication with an inlet of the aerosol generator unit, first and second valves along the first flow path and third and fourth valves along the second flow path, the valves arranged such that the first flow path supplies the liquid formulation to the first syringe pump when the first valve is open and the second valve is closed, the second flow path supplies the liquid formulation to the second syringe pump when the third valve is open and the fourth valve is closed, the first flow path supplying the liquid formulation to the aerosol generator unit when the first valve is closed and the second valve is open, and the second flow path supplying the liquid formulation to the aerosol generator unit when the third valve is closed and the fourth valve is open. 5. The drug delivery system of claim 4, further comprising: a control system operable to activate the aerosol generator unit and the pumping unit, the control system effecting initial filling of the syringe pumps via retraction of a first piston of the first syringe pump and a second piston of the second syringe pump while maintaining the first and third valves open and the second and fourth valves closed, delivering the liquid formulation to the aerosol generator unit via advancement of the first piston while maintaining the first and fourth valves closed, activating the second syringe pump near the end of a delivery cycle of the first syringe pump via advancement of the second piston while maintaining the fourth valve open and the third valve closed, refilling the first syringe pump via retraction of the first piston while maintaining the first valve open and the second valve closed, activating the first syringe pump near the end of the delivery cycle of the second syringe pump via advancement of the first piston while maintaining the second valve open and the first valve closed. 6. The drug delivery system of claim 1, wherein the aerosol confinement member includes at least one baffle therein and/or a drainage port at a lower end of the aerosol confinement member adapted to attach to a condensate collection device. 7. The drug delivery system of claim 1, wherein the pumping unit and the aerosol generator unit include disposable parts and reusable parts, the disposable parts including the capillary passage through which the liquid formulation is ejected as an aerosol and wetted parts of the pumping unit, the wetted parts including a screening member operable to trap particles in the liquid formulation above a predetermined size, the screening member located upstream of an inlet to the aerosol generator unit. 8. The drug delivery system of claim 1, further comprising: a source of the liquid formulation containing a lung surfactant adapted for delivery as an aerosol to an infant's lungs. 9. The drug delivery system of claim 1, wherein the gas heated by the second heater body is received from a source of pressurized gas connected to the aerosol confinement member, the source of pressurized gas supplying gas at a flow rate of about 1 to 6 liters per minute. 10. The drug delivery system of claim 1, wherein the patient interface comprises a continuous positive airway pressure (CPAP) adaptor operable to deliver an aerosol to a patient. 11. The drug delivery system of claim 1, wherein the aerosol confinement member is sealed to the distal end of the first heater body. 12. A drug delivery system operable to produce an aerosol, the drug delivery system comprising: an aerosol generator unit comprising a heater having a heater body;a capillary tube fitted within the heater body and adapted to form an aerosol when a liquid formulation in the capillary tube is heated by the heater to volatilize at least some of the liquid formulation therein, the capillary tube having a capillary tube inlet and a capillary tube outlet;a sheath gas passage contained outside the heater body and separated from the capillary tube and operable to receive a ventilated or hospital gas, the sheath gas passage having a sheath gas passage inlet and a sheath gas passage outlet;an aerosol confinement member arranged at a distal end of the heater body of the aerosol generator unit, the aerosol confinement member configured to connect the capillary tube outlet and the sheath gas passage outlet, wherein the capillary tube outlet is configured to inject the aerosol into the aerosol confinement member and the gas passage outlet is configured to inject the ventilated or hospital gas into the aerosol confinement member, said aerosol confinement member arranged to mix aerosol produced by the capillary tube with the ventilated or hospital gas from the sheath gas passage in a manner that reduces condensation of aerosol to produce a mixed aerosol and to direct the mixed aerosol into a flow passage;a pumping unit adapted to supply the liquid formulation to the aerosol generator unit; andthe flow passage having an inlet end in fluid communication with an outlet of the aerosol confinement member and an outlet end adapted for connection to a patient interface which supplies ventilation and the mixed aerosol to a patient's lungs. 13. The assembly of claim 12, further comprising: at least one condensate collector adapted to collect condensed liquid or liquid produced by the capillary tube. 14. The assembly of claim 12, wherein the pumping unit includes one syringe pump and a pair of valves operable to supply the liquid formulation into an inlet of the aerosol generator unit. 15. The assembly of claim 12, wherein the pumping unit includes two syringe pumps and a valving arrangement operable to supply the liquid formulation into an inlet of one syringe pump during delivery of the liquid formulation to the aerosol generator unit by the other syringe pump. 16. The assembly of claim 15, wherein the valving arrangement includes an inlet which can be connected to a source of the liquid formulation, first and second flow paths in fluid communication with the inlet, an outlet in fluid communication with an inlet of the aerosol generator unit, first and second valves along the first flow path and third and fourth valves along the second flow path, the valves arranged such that the first flow path supplies the liquid formulation to the first syringe pump when the first valve is open and the second valve is closed, the second flow path supplies the liquid formulation to the second syringe pump when the third valve is open and the fourth valve is closed, the first flow path supplying the liquid formulation to the aerosol generator unit when the first valve is closed and the second valve is open, and the second flow path supplying the liquid formulation to the aerosol generator unit when the third valve is closed and the fourth valve is open. 17. The assembly of claim 12, wherein the aerosol confinement member includes at least one baffle therein and/or a drainage port at a lower end of the aerosol confinement member adapted to attach to a condensate collection device. 18. The assembly of claim 12, wherein the pumping unit and the aerosol generator unit include disposable parts and reusable parts, the disposable parts including the capillary passage through which the liquid formulation is ejected as an aerosol and wetted parts of the pumping unit, the wetted parts including a screening member operable to trap particles in the liquid formulation above a predetermined size, the screening member located upstream of an inlet to the aerosol generator unit. 19. The assembly of claim 18, comprising: a control system operable to activate the aerosol generator unit and the pumping unit, the control system effecting initial filling of a first syringe pump and a second syringe pump via retraction of a first piston of the first syringe pump and a second piston of the second syringe pump while maintaining first and third valves open and second and fourth valves closed, delivering the liquid formulation to the aerosol generator unit via advancement of the first piston while maintaining the first and fourth valves closed, activating the second syringe pump near the end of a delivery cycle of the first syringe pump via advancement of the second piston while maintaining the fourth valve open and the third valve closed, refilling the first syringe pump via retraction of the first piston while maintaining the first valve open and the second valve closed, activating the first syringe pump near an end of a delivery cycle of the second syringe pump via advancement of the first piston while maintaining the second valve open and the first valve closed. 20. The assembly of claim 12, further comprising: a source of the liquid formulation containing a lung surfactant adapted for delivery as an aerosol to an infant's lungs.
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