Multiple impact microprojection applicators and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
A61M-005/158
출원번호
US-0203378
(2014-03-10)
등록번호
US-10195409
(2019-02-05)
발명자
/ 주소
Bourne, Doug
Shastry, Ashutosh
Le, Anthony
Singh, Parminder
출원인 / 주소
Corium International, Inc.
대리인 / 주소
McDermott Will & Emery LLP
인용정보
피인용 횟수 :
0인용 특허 :
253
초록
Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.
대표청구항▼
1. A method of delivering a therapeutic agent to a subject, comprising: applying to a skin site of a subject, an applicator comprising at least one plunger element, at least one microprojection retained on a distal surface of the plunger, and an actuator;actuating the actuator to convey an external
1. A method of delivering a therapeutic agent to a subject, comprising: applying to a skin site of a subject, an applicator comprising at least one plunger element, at least one microprojection retained on a distal surface of the plunger, and an actuator;actuating the actuator to convey an external force to the at least one plunger element such that an energy required for the at least one microprojection to penetrate the skin site is delivered in multiple, discrete quanta and/or impacts at the skin site;wherein, the multiple, discrete quanta and/or impacts are created by at leastthe plunger comprising multiple energy-mass systems, each system having a different time constant, wherein each of the energy-mass systems has a progressively higher time constant such that the plunger elements impact the skin site in a defined sequence. 2. The method of claim 1, wherein a maximum strain and/or strain rate is not exceeded by any of the multiple, discrete quanta and/or impacts. 3. The method of claim 1, further comprising delaying between impacts at the skin site a sufficient time to allow a strain from a previous impact at the skin site to dissipate. 4. The method of claim 1, wherein the at least one microprojection partially penetrates the skin site from a first impact, further comprising: detaching the at least one microprojection from the plunger distal end. 5. The method of claim 1, wherein each energy-mass system includes a spring and a mass element, further comprising adjusting a spring constant of one or more springs in the energy-mass systems to modify a delay in impact from the plunger elements. 6. The method of claim 5, further comprising: adjusting a mass of the mass elements thereby to modify a delay in impact from the plunger elements. 7. The method of claim 1, further comprising: wherein the applicator further includes a vibration element and controlling an amplitude of the vibration element to limit an impact strain from one or more of the multiple, discrete quanta and/or impacts. 8. The method of claim 1, further comprising: wherein the applicator further includes a vibration element and controlling a frequency of the vibration element to limit an impact strain from one or more of the multiple, discrete quanta and/or impacts. 9. The method of claim 1, wherein the at least one plunger element contacts a subject's skin with an energy of about 0.15-0.2 J. 10. The method of claim 1, wherein the multiple, discrete quanta and/or impacts are further created by the applicator comprising a plurality of plunger elements and an asynchronous release mechanism such that the plunger elements are released at different time periods. 11. The method of claim 1, wherein the multiple, discrete quanta and/or impacts are further created by the applicator comprising a plurality of plunger elements each comprising a dashpot element having a different damping coefficient. 12. The method of claim 1, wherein the multiple, discrete quanta and/or impacts are further created by the applicator comprising a plurality of plunger elements, each having a different type of spring. 13. An applicator, comprising: at least a first plunger element comprising a first energy-mass system, the first plunger element having a first restrained position and a second extended position, the first plunger element comprising a distal end on which at least one microprojection can be retained;at least a second energy-mass system;wherein the first and second energy-mass systems each has a different time constant, and each energy-mass system has a first restrained position and a second extended position;an actuating member that can convey an external force to at least the first plunger element to release the first plunger element from the first restrained position; andat least one microprojection attached to a distal surface of the plunger element distal end;wherein the first energy-mass system has a faster time constant than the second energy-mass system such that the energy required for the at least one microprojection to penetrate a subject's skin at an application site is delivered by multiple, discrete impacts at the skin by the first and second energy-mass systems. 14. The applicator of claim 13, wherein the first and second energy-mass systems each includes a mass and an energy-storing element. 15. The applicator of claim 14, wherein the energy-storing elements are elastic energy elements each selected from a compression spring, a coil spring, a wave spring, and a slotted spring. 16. The applicator of claim 14, wherein the mass of the first energy-mass system is different than the mass of the second energy-mass system. 17. The applicator of claim 13, further comprising a third energy-mass system, wherein the third energy-mass system has a different time constant than the first or second energy-mass systems. 18. The applicator of claim 17, wherein the third energy-mass system has a slower time constant than the first or second energy-mass systems. 19. The applicator of claim 13, further comprising a housing member at least partially housing the first plunger element and actuating member. 20. The applicator of claim 13, wherein the at least one microprojection is a microprojection array comprising a plurality of microprojections. 21. The applicator of claim 20, wherein at least some of the plurality of microprojections are dissolvable or erodible microprojections. 22. The applicator of claim 20, wherein at least some of the plurality of microprojections include at least one therapeutic agent selected from a drug, a small molecule, a peptide or protein, or a vaccine. 23. The applicator of claim 20, wherein at least a portion of the plurality of microprojections are detachable from the microprojection array. 24. The applicator of claim 12, further comprising: a damper positioned between at least one of the energy-storing elements and a proximal surface of the first plunger element distal end.
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Laura Graves Spalding VanRijswijck ; Gretchen Louise Elder ; Donald Carroll Roe, Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon.
Fishman Henry (5173 Linnean Ter. NW. Washington DC 20008) Johnson Gary D. (New York NY) Smith Jeffrey T. (Arlington VA) Holtz Leonard (Oceanside NY), Allergy testing apparatus and method.
Drelich Arthur (Plainfield NJ) Bassett Alton H. (Princeton NJ) James William (East Windsor NJ) Kennette John W. (Somerville NJ) McMeekin Linda J. (Bound Book NJ), Apertured non-woven fabric.
Trautman, Joseph C.; Keenan, Richard L.; Samiee, Ahmad P.; Lin, WeiQi; Cormier, Michel J. N.; Matriano, James A.; Daddona, Peter E., Apparatus and method for piercing skin with microprotrusions.
Trautman,Joseph C.; Keenan,Richard L.; Samiee,Ahmad P.; Lin,WeiQi; Cormier,Michel J. N.; Matriano,James A.; Daddona,Peter E., Apparatus and method for piercing skin with microprotrusions.
Trautman,Joseph C.; Keenan,Richard L.; Samiee,Ahmad P.; Lin,WeiQi; Cormier,Michel J. N.; Matriano,James A.; Daddona,Peter E., Apparatus and method for piercing skin with microprotrusions.
Yuzhakov Vadim Vladimirovich ; Sherman Faiz Feisal ; Owens Grover David ; Gartstein Vladimir, Apparatus and method for using an intracutaneous microneedle array.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Apparatus for addressing needle array electrodes for electroporation therapy.
Saito Shiro (Tokoname) Kawamoto Ryuichi (Tokoname) Kondo Mineharu (Tokoname) Sakakibara Shigeru (Tokoname JPX), Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine.
Trautman, Joseph C.; Worsham, Robert Wade; Bayramov, Danir F.; Bowers, Danny Lee; Klemm, Steven Richard; Singh, Parminder, Applicators for microneedles.
Gelfer Ala (600 S. Curson #326 Los Angeles CA 90036) Gelfer Arkadiy (600 S. Curson #326 Los Angeles CA 90036) Gelfer Stan (1022 N. Vista St. #5 Los Angeles CA 90046), Body treatment pad having a multiple number of sharpened skin-penetration protuberances.
Chester Martin H. (25310 Tierra Grande Dr. Carmel CA 93921) Norman Cary A. (440 Juniper Ave. Pacific Grove CA 93950), Clamp-on nerve stimulator and locator.
Lastovich, Alexander G.; Fentress, James K.; Griggs, Julia; Pettis, Ronald J.; Sutter, Diane; Martin, Frank E.; Haider, M. Ishaq, Device and method for delivering or withdrawing a substance through the skin.
Cormier,Michel J. N.; Neukermans,Armand P.; Block,Barry; Theeuwes,Felix T.; Amkraut,Alfred A., Device and method for enhancing transdermal flux of agents being delivered or sampled.
Prausnitz, Mark R.; Allen, Mark G.; Henry, Sebastien; McAllister, Devin V.; Ackley, Donald E.; Jackson, Thomas, Devices and methods for enhanced microneedle penetration of biological barriers.
Wong Ooi (Fremont CA) Nguyen Thuytien N. (Hayward CA), Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters.
Lum Paul ; Leonard Leslie A. ; Verdonk Edward D. ; Freeman Dominique M. ; Greenstein Michael ; Keely-Templin Catherine, Extraction and transportation of blood for analysis.
Bishop Delmar J. (Hamilton OH), Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its con.
Cusack Robert F. (Edison NJ) Mintz Michael D. (Edison NJ), Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling.
Safabash Jason H. ; McConnell Susan M. ; Adair Randy W. ; Funderburk Jeffery V. ; Marano April A. ; Field Jeffrey F., Insertion device for an insertion set and method of using the same.
Ahr Nicholas A. (Cincinnati OH) Louis Paul R. (Cincinnati OH) Mullane ; Jr. William I. (Cincinnati OH) Ouellette William R. (Cincinnati OH), Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impr.
Johnson, Peter R.; Emery, Marla R.; Wolter, James T.; Raeder-Devens, Jennifer E.; Duan, Daniel C.; David, Moses M.; Choi, Hye-Ok, Masking method for coating a microneedle array.
Singh, Parminder; Bairamov, Danir; Chen, Guohua; Worsham, Robert Wade, Method and device for transdermal delivery of parathyroid hormone using a microprojection array.
Gore Gerald W. (Placentia CA) Milner ; Jr. Philip H. (Newport Beach CA) Petersen Gordon A. (Fountain Valley CA), Method for making perforated articles.
Sherman, Faiz Feisal; Gartstein, Vladimir, Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation.
Calanchi Massimo,ITX ; Zema Marco,ITX ; Brunetti Gabriele,ITX ; Giorgetti Enzo,ITX, Method for targeted and controlled release of drugs in the intestinal tract and more particularly in the colon.
Guy Richard ; Rao Girish ; Glikfeld Peretz,ILX ; Cullander Christopher ; Hinz Robert S., Method for the iontophoretic non-invasive determination of the in vivo concentration level of glucose.
Guy Richard (San Francisco CA) Rao Girish (San Francisco CA), Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic su.
Bracht Stefan,DEX, Method for the low-waste manufacture of diskoid moulded bodies containing active ingredients, and transdermal therapeutic systems containing same.
Rowland William P. (Southington CT) Martin David C. (Berlin CT), Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold.
Turi Mordechai (Princeton Junction NJ) DeRossett Edmund Z. (Mercerville NJ) Yang Ching-Yun M. (Princeton Junction NJ), Method of forming textile-like apertured plastic films.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of programming an array of needle electrodes for electroporation therapy of tissue.
Ghartey-Tagoe, Esi; Wendorf, Janet; Williams, Steve; Singh, Parminder; Worsham, Robert Wade; Trautman, Joseph C.; Bayramov, Danir; Bowers, Danny Lee; Klemm, Andrew Richard; Klemm, Steven Richard; Chen, Guohua, Method of vaccine delivery via microneedle arrays.
Ivanov Konstantin ; Reinhardt William ; Routh Shakti ; Pohle Michael, Microbial barrier vented package for sterile medical devices and method of packaging.
Yuzhakov, Vadim Vladimirovich; Gartstein, Vladimir; Owens, Grover David, Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup.
Delmore, Michael D.; Fleming, Patrick R.; Huntley, Douglas A.; Keister, Jamieson C.; Thomas, Cristina U.; Ferber, Richard H., Microneedle arrays and methods of manufacturing the same.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Minimally invasive apparatus and method to electroporate drugs and genes into tissue.
Curro John J. (Cincinnati OH) Baird James C. (Cincinnati OH) Gerth Donald L. (Cincinnati OH) Vernon George M. (West Chester OH) Linman E. Kelly (Cincinnati OH), Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimens.
Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
Lee Abraham P. (1428 Whitecliff Way Walnut Creek CA 94596) Northrup M. Allen (923 Creston Rd. Berkeley CA 94708) Ahre Paul E. (1299 Gonzaga Ct. Livermore CA 94550) Dupuy Peter C. (1736 Waldo Ct. Mode, Polymer micromold and fabrication process.
Curro John J. (Cincinnati OH) Trusty Alan J. (Bethel OH) Vernon George M. (West Chester OH), Production of formed material by solid-state formation with a high-pressure liquid stream.
Lothar W. Kleiner ; Robert M. Gale ; Randall G. Berggren ; Gilbert T. Tong ; Guohua Chen ; Keith E. Dionne ; Paul R. Houston, Rate controlling membranes for controlled drug delivery devices.
Turner Josephine S. (Kettleby CAX) Murray D. Gary (Willowdale CAX) Zuccolin John D. (Stouffville CAX) Li Ruey S. (Thornhill CAX), Substance transfer system for topical application.
Lyons Julie W. (North Bend OH) Battrell Charles F. (Cincinnati OH) Ouellette William R. (Cincinnati OH) Curro John J. (Cincinnati OH), Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement.
Allison Kenneth C. (Crystal Lake IL) Allison Roger D. (Bensenville IL) Allison Charlotte C. (Crystal Lake IL), Trans-dermal medication application cell.
Lee Hai Bang (Taejeon KRX) Shin Bung Chul (Taejeon KRX), Transdermal administration method of protein or peptide drug and its administration device thereof.
Santus Giancarlo (Milan CA ITX) Kim Aeri (Mountain View CA) Francoeur Michael L. (Los Altos CA) Bremer Ulrike (Menlo Park CA), Transdermal delivery of alpha adrenoceptor blocking agents.
Cartmell James V. (Xenia OH) Sturtevant Wayne R. (Centerville OH) Bausmith ; III William E. (Batavia OH) Wolf Michael L. (West Milton OH), Wound dressing product containing a porous layer.
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