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5′ triphosphate oligonucleotide with blunt end and uses thereof

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/113
  • A61K-031/7088
  • C07H-021/00
  • C12N-015/117
  • A61K-031/713
  • A61K-045/06
출원번호 US-0151254 (2016-05-10)
등록번호 US-10196638 (2019-02-05)
우선권정보 EP-08009406 (2008-05-21); EP-08015261 (2008-08-29); EP-08018243 (2008-10-17)
발명자 / 주소
  • Hartmann, Gunther
  • Schlee, Martin
출원인 / 주소
  • Rheinische Friedrich-Wilhelms-Universität Bonn
대리인 / 주소
    Leydig, Voit & Mayer, Ltd.
인용정보 피인용 횟수 : 0  인용 특허 : 36

초록

The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells expressing RIG-I. The present invention further provides an oligonucleotide which is capable of activating RIG-I and which has target gene-silen

대표청구항

1. An oligonucleotide preparation comprising an essentially homogenous population of an oligonucleotide, wherein the oligonucleotide has two blunt ends each bearing a 5′ triphosphate,wherein the oligonucleotide comprises at least 1 ribonucleotide at the 5′ end at the blunt ends,wherein the 5′ tripho

이 특허에 인용된 특허 (36)

  1. Ecker David J. (Carlsbad CA), Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides.
  2. Cho-Chung Yoon S. (7017 Kenhill Rd. Bethesda MD 20817), Antisense oligonucleotides of human regulatory subunit RIaof cAMP-dependent prot.
  3. Bentwich,Itzhak, Bioinformatically detectable group of novel HIV regulatory genes and uses thereof.
  4. Bentwich, Itzhak, Bioinformatically detectable group of novel viral regulatory genes and uses thereof.
  5. Bentwich, Itzhak, Bioinformatically detectable human herpesvirus 5 regulatory gene.
  6. Bentwich, Itzhak, Bioinformatically detectable viral regulatory genes.
  7. Wilfried Seifert, Compositions and methods for inhibiting cox-2 expression and treating cox-2 associated disorders by using cox-2 antisense oligonucleotides.
  8. Metelev Valeri (Shrewsbury MA) Agrawal Sudhir (Shrewsbury MA), Hybrid oligonucleotide phosphorothioates.
  9. Metelev Valeri,RUX ; Agrawal Sudhir, Hybrid oligonucleotide phosphorothioates.
  10. Valeri Metelev RU; Sudhir Agrawal, Hybrid oligonucleotide phosphorothioates.
  11. Agrawal Sudhir (Shrewsbury MA) Leiter Josef M. E. (Brooklyn NY) Palese Peter (Leonia NJ) Zamecnik Paul C. (Shrewsbury MA), Inhibition of influenza virus replication by oligonucleotide phosphorothioates.
  12. Harel Bellan,Annick; Ait Si Ali,Slimane; Cabon Georget,Florence; Chauchereau,Anne; Dautry,Francois, Inhibitor oligonucleotides and their use for specific repression of a gene.
  13. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
  14. Iba, Hideo; Haraguchi, Takeshi, Method for inhibiting function of micro-RNA.
  15. Dimmeler, Stefanie; Zeiher, Andreas M.; Bonauer, Angelika; Urbich, Carmen, Method for treating myocardial infarct.
  16. Stec Wojciech J. (Lodz PLX) Grajkowski Andrzej (Lodz PLX) Uznanski Bogdan (Lodz PLX), Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phosphola.
  17. Vaghefi Morteza M. (San Diego CA), Method of preparing 2′-O-methyl cytidine monomers useful in oligomer synthesis.
  18. Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
  19. Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
  20. Stec Wojciech J. (Lodz PLX) Uznanski Bogdan (Lodz CA PLX) Bergot B. John (Redwood City CA) Hirschbein Bernard L. (San Francisco CA) Fearson Karen L. (Union City CA), Method of synthesizing sulfurized oligonucleotide analogs.
  21. Beigelman Leonid ; Burgin Alex ; Beaudry Amber ; Karpeisky Alexander ; Matulic-Adamic Jasenka ; Sweedler David, Nucleoside triphosphates and their incorporation into oligonucleotides.
  22. Kerr Ian M. (London GB2) Brown Ronald E. (Hemel Hempstead GB2) Hovanessian Ara G. (London GB2), Nucleotide inhibitor of protein synthesis.
  23. Cook, Phillip D.; Wang, Guangyi; Bruice, Thomas W.; Boyle, Nicholas A.; Leeds, Janet M.; Brooks, Jennifer L.; Prhavc, Marija; Ariza, Maria Eugenia; Fagan, Patrick C.; Jin, Yi; Rajwanshi, Vivek K.; Tucker, Kathleen D., Nucleotide mimics and their prodrugs.
  24. Cook, Phillip D.; Wang, Guangyi; Bruice, Thomas W.; Boyle, Nicholas A.; Leeds, Janet M.; Brooks, Jennifer L.; Prhavc, Marija; Ariza, Maria Eugenia; Fagan, Patrick C.; Jin, Yi; Rajwanshi, Vivek K.; Tucker, Kathleen D., Nucleotide mimics and their prodrugs.
  25. Cook,Phillip D.; Wang,Guangyi; Bruice,Thomas W.; Boyle,Nicholas A.; Leeds,Janet M.; Brooks,Jennifer L.; Prhavc,Marija; Ariza,Maria Eugenia; Fagan,Patrick C.; Jin,Yi; Rajwanshi,Vivek K.; Tucker,Kathleen D., Nucleotide mimics and their prodrugs.
  26. Manoharan, Muthiah; Mohan, Venkatraman, Oligonucleotides having A-DNA form and B-DNA form conformational geometry.
  27. Manoharan,Muthiah; Mohan,Venkatraman; Cook,Phillip Dan; Kawasaki,Andrew M., Oligonucleotides having A-DNA form and B-DNA form conformational geometry.
  28. Muthiah Manoharan ; Venkatraman Mohan, Oligonucleotides having A-DNA form and B-DNA form conformational geometry.
  29. Imbach Jean-Louis,FRX ; Rayner Bernard,FRX, Phosphorothioate triester oligonucleotides and method of preparation.
  30. Krasnoperov, Valery; Kertesz, Nathalie; Reddy, Ramachandra; Gill, Parkash; Zozulya, Sergey, Polypeptide compounds for inhibiting angiogenesis and tumor growth.
  31. Livache Thierry,FRX ; Fouque Brigitte,FRX ; Teoule Robert,FRX, Process for preparing double-stranded RNA, and its applications.
  32. Yau Eric K. (Kirkland WA), Process for preparing phosphorothioate oligonucleotides.
  33. Ecker David J. ; Bruice Thomas W. ; Vickers Timothy A., Reagents and methods for modulating gene expression through RNA mimicry.
  34. Eppstein Deborah A. (Los Altos CA) Fraser-Smith Elizabeth B. (Los Altos CA) Matthews Thomas R. (Los Gatos CA), Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.
  35. Bentwich, Itzhak, Vaccinia virus-related nucleic acids and microRNA.
  36. Wyrzykiewicz, Tadeusz; Cook, Phillip Dan, α-modified nucleoside triphosphates.

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