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Short duration depot formulations 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/00
  • A61K-047/10
  • A61K-047/14
  • A61K-009/06
  • A61K-031/445
  • A61K-038/27
  • A61K-047/34
출원번호 US-0267070 (2016-09-15)
등록번호 US-10201496 (2019-02-12)
발명자 / 주소
  • Chen, Guohua
  • Priebe, David T.
출원인 / 주소
  • Durect Corporation
인용정보 피인용 횟수 : 0  인용 특허 : 166

초록 ▼

Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short

대표청구항 ▼

1. A composition comprising: (a) a polyorthoester having a weight average molecular weight ranging from about 3000 to about 10,000;(b); and(c) bupivacaine base or pharmaceutically acceptable salt thereof in an amount ranging from about 1 wt % to about 20 wt % of the composition,wherein the ratio of

이 특허에 인용된 특허 (166)

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  131. Heller Jorge ; Ng Steven Y., Polymers with controlled physical state and bioerodibility.
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  132. Govaerts Marcel K. (Olen BEX) Gielen Hendrik A. L. (Kasterlee BEX) Dompas John M. A. (Olen BEX), Process and apparatus for casting a strip with laterally extending lugs.
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  133. Sparer Randall V. (Lawrence KS) Zentner Gaylen (Lawrence KS), Process for the manufacture of bioerodible poly (orthoester)s and polyacetals.
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  134. Goldenheim Paul ; Lacouture Peter ; Donigi-Gale Donna ; Chasin Mark ; Sackler Richard, Prolonged anesthesia in joints and body spaces.
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  135. Sackler Richard ; Goldenheim Paul ; Chasin Mark, Prolonged local anesthesia with colchicine.
    상세보기
  136. Berde Charles B. (Brookline MA) Langer Robert S. (Newton MA), Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid.
    상세보기
  137. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsule of a water-soluble drug.
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  138. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsules and their production.
    상세보기
  139. Gombotz Wayne ; Pettit Dean ; Pankey Susan ; Lawter James Ronald ; Huang W. James, Prolonged release of GM-CSF.
    상세보기
  140. Mitchell James W. (St. Louis MO), Prolonged release of biologically active polypeptides.
    상세보기
  141. Eckenhoff James B. (Los Altos CA) Urquhart John (Palo Alto CA), Release rate adjustment of osmotic or diffusional delivery devices.
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  142. Himmelstein Kenneth J. (Omaha NE) Baustian Cara L. (Pearl River NY 4), Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use.
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  143. Joshi Abhay (Irvine CA) Ding Shulin (Irvine CA) Himmelstein Kenneth J. (Irvine CA), Reversible gelation compositions and methods of use.
    상세보기
  144. Hoeg Anne L. (Havnegaten CA NOX) Meadows David L. (Mission Viejo CA), Reversible gelation emulsion compositions and methods of use.
    상세보기
  145. Ng, Steven Y.; Shen, Hui Rong; Heller, Jorge, Semi-solid delivery vehicle and pharmaceutical compositions for delivery of granisetron.
    상세보기
  146. Illum Lisbeth,GB2, Small particle compositions for intranasal drug delivery.
    상세보기
  147. Oshlack Benjamin ; Chasin Mark ; Pedi ; Jr. Frank, Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer.
    상세보기
  148. Choi ; Nam S. ; Heller ; Jorge, Structured orthoester and orthocarbonate drug delivery devices.
    상세보기
  149. MacPhee Martin James ; Drohan William Nash ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, method of their production and use.
    상세보기
  150. Damanj Nalinkant C. (Cincinnati OH), Sustained release compositions for treating periodontal disease.
    상세보기
  151. Bawa Rajan (Fairport NY) Ruscio Dominic V. (Rochester NY), Sustained release formulation containing an ion-exchange resin.
    상세보기
  152. Bawa Rajan (Fairport NY) Deichert William G. (Macedon NY), Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1-C4) po.
    상세보기
  153. Bawa Rajan (Fairport NY), Sustained-release formulation containing and amino acid polymer.
    상세보기
  154. Tucker Marjorie M. (Holliston MA) Rueger David C. (Southborough MA) Sampath Kuber T. (Holliston MA), Terminally sterilized osteogenic devices and preparation thereof.
    상세보기
  155. Zook Gerald P. (802 W. 18th Pl. Eugene OR 97402), Topical drug delivery system.
    상세보기
  156. Drizen Alan,CAX ; Rothbart Peter,CAX ; Nath Gary M., Topical drug preparations.
    상세보기
  157. Zook Gerald P. (909 N. 8th St. ; Apt. B-2 Tacoma WA 98403), Topical medicating device.
    상세보기
  158. Shahinian ; Jr. Lee, Topical ophthalmic analgesic preparations for sustained and extended corneal analgesia.
    상세보기
  159. Ben-Amoz Daniel (226 Murray Dr. Allentown PA 18104), Ultrasonic transdermal application of steroid compositions.
    상세보기
  160. Bardsley Hazel Judith,GBX ; Gristwood Robert William,GBX ; Richards Andrew John McGlashan,GBX, Use of levobupivacaine as an anesthetic agent.
    상세보기
  161. Bardsley Hazel Judith,GBX ; Gristwood Robert William,GBX, Use of levobupivacaine in a patient having depressed myocardial contractility.
    상세보기
  162. Gennery Brian Albert,GBX, Use of levobupivacaine in paediatric surgery.
    상세보기
  163. Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
    상세보기
  164. Roorda Wouter E. (Newark CA) Ehnow Fred (Mountain View CA), Viscous suspensions of controlled-release drug particles.
    상세보기
  165. Yim, Zachary; Zupon, Michael A.; Chaudry, Imtiaz A., Zinc-protamine-alpha interferon complex.
    상세보기
  166. Vaugn William M. ; Van Hamont John E. ; Setterstrom Jean A., sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres.
    상세보기

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