최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0933813 (2013-07-02) |
등록번호 | US-10201672 (2019-02-12) |
발명자 / 주소 |
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출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 883 |
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.
1. An inhaler comprising: a housing, a mouthpiece, and a cartridge contained within the housing, the cartridge comprising two or more rigid parts;wherein at least one of the two or more rigid parts of the cartridge is a container, wherein the mouthpiece is configured to translocate the container fro
1. An inhaler comprising: a housing, a mouthpiece, and a cartridge contained within the housing, the cartridge comprising two or more rigid parts;wherein at least one of the two or more rigid parts of the cartridge is a container, wherein the mouthpiece is configured to translocate the container from a powder containment position in a first location to a dosing position in a second location different than the first location by moving the container relative to another of the at least two or more rigid parts of the cartridge thereby creating an entrance into and an exit from the container when in the dosing position;wherein in the powder containment position, there is not an airflow passageway through the container; andwherein in the dosing position there is an airflow passageway through the container and 10% to 70% of total airflow through the inhaler enters and exits the cartridge. 2. The inhaler of claim 1, wherein the mouthpiece is configured to engage a moveable member. 3. The inhaler of claim 1, further comprising a cartridge housing to accommodate the container. 4. The inhaler of claim 1, wherein the container is configured to hold a dry powder medicament including at least one active ingredient. 5. The inhaler of claim 4, wherein the least one active ingredient is a peptide, polypeptide, protein, or a combination thereof. 6. The inhaler of claim 4, wherein the active ingredient is insulin, glucagon-like peptide 1, oxyntomodulin, peptide YY, exendin, heparin, calcitonin, felbamate, sumatriptan, parathyroid hormone, growth hormone, erythropoietin, AZT, DDI, granulocyte macrophage colony stimulating factor, lamotrigine, chorionic gonadotropin releasing factor, luteinizing releasing hormone, beta-galactosidase, exendin, vasoactive intestinal peptide, an argatroban, anti-SSX-241-49, anti-NY-ESO-1, anti-PRAME, anti-PSMA, anti-Melan-A, anti-tyrosinase, or a combination thereof. 7. The inhaler of claim 4, wherein the active ingredient is insulin, glucagon-like peptide 1, oxyntomodulin, peptide YY, exendin, analogs thereof, or a combination thereof. 8. The inhaler of claim 4, wherein the active ingredient is insulin granulocyte macrophage colony stimulating factor (GM-CSF), parathyroid hormone, parathyroid hormone related protein, or parathyroid hormone 1-34. 9. The inhaler of claim 4, wherein the active ingredient is a neuroactive agent. 10. The inhaler of claim 4, wherein the active ingredient is oxyntomodulin. 11. The inhaler of claim 4, wherein the dry powder medicament comprises a diketopiperazine. 12. The inhaler of claim 11, wherein the diketopiperazine is 13. An inhaler comprising: a housing a mouthpiece, and a removable cartridge contained within the housing, the cartridge including two or more rigid parts;wherein at least one of the two or more rigid parts of the removable cartridge is a container, wherein the mouthpiece is configured to translocate the container from a powder containment position in a first location to a dosing position in a second location different than the first location by moving the container relative to another of the at least two or more rigid parts of the cartridge thereby creating an entrance into and an exit from the container when in the dosing position;wherein in the powder containment position, there is not an airflow passageway through the container; andwherein in the dosing position there is an airflow passageway through the container and 10% to 70% of total airflow through the inhaler enters and exits the removable cartridge. 14. The inhaler of claim 13, wherein the mouthpiece is configured to engage a moveable member. 15. The inhaler of claim 1, further comprising a cartridge housing to accommodate the container. 16. The inhaler of claim 13, wherein the removable container is configured to hold a dry powder medicament including at least one active ingredient. 17. The inhaler of claim 16, wherein the least one active ingredient is a peptide, polypeptide, protein, or a combination thereof. 18. The inhaler of claim 16, wherein the active ingredient is insulin, glucagon-like peptide 1, oxyntomodulin, peptide YY, exendin, heparin, calcitonin, felbamate, sumatriptan, parathyroid hormone, growth hormone, erythropoietin, AZT, DDI, granulocyte macrophage colony stimulating factor, lamotrigine, chorionic gonadotropin releasing factor, luteinizing releasing hormone, beta-galactosidase, exendin, vasoactive intestinal peptide, an argatroban, anti-SSX-241-49, anti-NY-ESO-1, anti-PRAME, anti-PSMA, anti-Melan-A, anti-tyrosinase, or a combination thereof. 19. The inhaler of claim 16, wherein the active ingredient is insulin, glucagon-like peptide 1, parathyroid hormone, oxyntomodulin, peptide YY, exendin, analogs thereof, or a combination thereof. 20. The inhaler of claim 16, wherein the active ingredient is granulocyte macrophage colony stimulating factor (GM-CSF), parathyroid hormone, parathyroid hormone related protein, or parathyroid hormone 1-34. 21. The inhaler of claim 16, wherein the active ingredient is a neuroactive agent, a vasoactive agent, a sedative, an antibiotic, or a vaccine. 22. The inhaler of claim 16, wherein the active ingredient is oxyntomodulin. 23. The inhaler of claim 16, wherein the dry powder medicament comprises a diketopiperazine. 24. The inhaler of claim 23, wherein the diketopiperazine is 25. An inhaler comprising: a housing, a mouthpiece, and a cartridge contained with the housing, the cartridge including two or more rigid parts; wherein at least one of the two or more rigid parts of the cartridge is a container, wherein the mouthpiece is configured to engage a movable member within the housing and translocate the container from a powder containment position in a first location to a dosing position in a second location different than the first location by moving the container relative to another of the at least two or more rigid parts of the cartridge thereby creating an entrance into and an exit from the container when in the dosing position; wherein in the powder containment position, there is not an airflow passageway through the container; wherein in the dosing position there is an airflow passageway through the container and 10% to 70% of total airflow through the inhaler enters and exits the cartridge; and wherein the container is configured to hold a dry powder medicament including insulin and 26. An inhaler comprising: a housing, a mouthpiece, and a removable cartridge contained within the housing, the cartridge including two or more rigid parts; wherein at least one of the two or more rigid parts of the removable cartridge is a container, wherein the mouthpiece is configured to engage the removable cartridge within the housing and translocate the container from a powder containment position in a first location to a dosing position in a second location different than the first location by moving the container relative to another of the at least two or more rigid parts of the removable cartridge thereby creating an entrance into and an exit from the container when in the dosing position; wherein in the powder containment position, there is not an airflow passageway through the container; wherein in the dosing position there is an airflow passageway through the container and 10% to 70% of total airflow through the inhaler enters and exits the removable cartridge; and wherein the removable cartridge is configured to hold a dry powder medicament including glucagon-like peptide 1 and 27. An inhaler comprising: a housing, a mouthpiece, and a removable cartridge contained with the housing, the cartridge including two or more rigid parts; wherein at least one of the two or more rigid parts of the removable cartridge is a container, wherein the mouthpiece is configured to engage the removable cartridge within the housing and translocate the container from a powder containment position in a first location to a dosing position in a second location different than the first location by moving the container relative to another of the at least two or more rigid parts of the removable cartridge thereby creating an entrance into and an exit from the container when in the dosing position; wherein in the powder containment position, there is not an airflow passageway through the container; wherein in the dosing position there is an airflow passageway through the container and 10% to 70% of total airflow through the inhaler enters and exits the removable cartridge, wherein the removable cartridge is configured to hold a dry powder medicament including oxyntomodulin and
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