Tissue filler compositions and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-027/50
A61K-041/00
A61K-008/49
A61K-008/73
A61Q-019/08
A61L-027/52
A61L-027/54
A61N-005/06
A61L-027/20
A61L-027/58
A61B-018/00
출원번호
US-0301189
(2015-04-01)
등록번호
US-10207029
(2019-02-19)
국제출원번호
PCT/CA2015/050261
(2015-04-01)
국제공개번호
WO2015/149177
(2015-10-08)
발명자
/ 주소
Nikolis, Andreas
Hébert, Lise
출원인 / 주소
KLOX TECHNOLOGIES INC.
대리인 / 주소
BCF LLP
인용정보
피인용 횟수 :
0인용 특허 :
55
초록▼
The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and
The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.
대표청구항▼
1. A method for stimulating collagen synthesis comprising: administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium, Eosin Y, and Fluorescein; andilluminating the area to be treated with light having a wavelength which can be
1. A method for stimulating collagen synthesis comprising: administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium, Eosin Y, and Fluorescein; andilluminating the area to be treated with light having a wavelength which can be absorbed by Eosin Y and Fluorescein;wherein the method stimulates collagen synthesis in the area to be treated. 2. A method for cosmetic enhancement of soft tissue comprising: intradermally or subdermally administering a composition to an area to be treated, wherein the composition comprises a tissue filler medium, Eosin Y, and Fluorescein; andilluminating the area to be treated with light having a wavelength which can be absorbed by Eosin Y and Fluorescein;wherein the method stimulates collagen synthesis in the area to be treated to cosmetically enhance the soft tissue. 3. The method of claim 1, wherein the area to be treated is soft tissue. 4. The method of claim 1, wherein the administering of the composition is by injection. 5. The method of claim 1, wherein the administering of the composition is by implantation. 6. The method of claim 1 or 2, wherein the composition is selected from a cohesive gel and a hydrated gel. 7. The method of claim 1 or 2, wherein the tissue filler is a dermal filler. 8. The method of claim 1 or 2, wherein the tissue filler medium comprises a polymer. 9. The method of claim 8, wherein the polymer is selected from proteins, peptides, polypeptides, polylysine, collagens, pro-collagens, elastins, and laminins. 10. The method of claim 8, wherein the polymer is selected from poly(vinyl alcohol), polyethylene glycol, polyvinlyl amine, polyallylamine, deacetylated polyacrylamide, polyacrylic acid, and polymethacrylic acid. 11. The method of claim 1 or 2, wherein the tissue filler medium comprises cross-linked hyaluronic acid. 12. The method of claim 1 or 2, wherein the composition further comprises light reflecting particles. 13. The method of claim 2, wherein intradermally or subdermally administering comprises providing a track of composition from external to the dermis to the composition. 14. A tissue filler composition comprising: a tissue filler medium; andat least Eosin Y and Fluorescein;wherein the composition is suitable for injection or implantation into a human. 15. The composition of claim 14, wherein the composition is a cohesive gel. 16. The composition of claim 14, wherein the composition is a hydrated gel. 17. The composition of claim 14, wherein the composition is transparent or translucent. 18. The composition of claim 14, wherein the tissue filler medium retains Eosin Y and Fluorescein within the composition during administering of the composition, and at least during a portion of the illumination. 19. The composition of claim 14, wherein the tissue filler medium is biodegradable. 20. The composition of claim 14, wherein the tissue filler medium comprises cross-linked hyaluronic acid. 21. The composition of claim 20, wherein the cross-linked hyaluronic acid is in particulate form. 22. The composition of claim 14, wherein the composition further comprises an injectable medium supporting the particles. 23. The composition of claim 14, wherein the injectable medium comprises hyaluronic acid which is relatively less cross-linked than the hyaluronic acid in particulate form. 24. The composition of claim 14, wherein the composition further comprises light reflecting particles. 25. The composition of claim 14, wherein Eosin Y and Fluorescein can be activated by light having a wavelength in the visible range. 26. The composition of claim 14, wherein Eosin Y and Fluorescein are not in a liposomal form in the composition.
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