[특허]Fluidic cartridge with valve mechanism

Fluidic cartridge with valve mechanism 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61J-001/06 B01L-003/00 G01N-021/00 G01N-015/06 C12Q-001/6806 C12Q-001/686 G01N-027/447
출원번호	US-0117053 (2015-04-30)
등록번호	US-10208332 (2019-02-19)
국제출원번호	PCT/US2015/028510 (2015-04-30)
국제공개번호	WO2015/179098 (2015-11-26)
발명자 / 주소	Eberhart, David Nielsen, William D. Franklin, Helen Jovanovich, Stevan B. Lehto, Dennis Chear, Kaiwan Klevenberg, James Park, Chungsoo Charles Smith, Corey Wunderle, Philip Justus King, David
출원인 / 주소	Eberhart, David
대리인 / 주소	Weaver Austin Villeneuve & Sampson LLP
인용정보	피인용 횟수 : 0 인용 특허 : 243

초록 ▼

Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

대표청구항 ▼

1. A cartridge comprising: (a) a body comprising a malleable material; and(b) a layer comprising a deformable material bonded to a surface of the body and sealing a fluidic channel that communicates with one or more valve bodies formed in a surface of the body;wherein: (i) the one or more valve bodies comprise a segment of the fluidic channel comprising a wall having a pair of ridges and a floor depressed into the surface,and(ii) the layer is bonded to the surface of the body and to the ridges such that the channel segment of the fluidic channel is sealed; andwherein a valve body sealed with the layer forms a valve configured to regulate fluid flow in the fluidic channel and closable by forcing the layer against the floor of the segment of the channel. 2. The cartridge of claim 1 comprising elements of a fluidic circuit including a fluid inlet, a fluid outlet and at least one compartment, which elements are fluidically connected through fluidic channels, wherein at least one fluidic channel comprises a valve body. 3. The cartridge of claim 2 comprising at least one compartment selected from a reagent compartment, a sample compartment, a mixing compartment, a reaction compartment and a waste compartment. 4. The cartridge of claim 2 wherein a fluid inlet or a fluid outlet comprises a via through the body. 5. The cartridge of claim 2 comprising at least one sample compartment configured to accept a swab. 6. The cartridge of claim 2 comprising at least one mixing chamber configured for bubbling of air through the mixing chamber. 7. The cartridge of claim 2 comprising a reaction chamber comprising a solid substrate for retaining analyte from a sample. 8. The cartridge of claim 2 comprising a pump configured as a depression in the surface. 9. The cartridge of claim 7 wherein the solid substrate comprises a material that binds nucleic acid. 10. The cartridge of claim 7 wherein the solid substrate comprises Whatman paper, a carboxylated particle, a sponge-like material, a polymer membrane, magnetically attractable particles, or glass particles. 11. The cartridge of claim 7 wherein the solid substrate binds a predetermined amount of material. 12. The cartridge of claim 2 comprising a reaction chamber comprising one or more thermally conductive walls and configured for thermal cycling. 13. The cartridge of claim 2 comprising at least one waste compartment. 14. The cartridge of claim 2 comprising a waste chamber, wherein the waste chamber comprises a material that degrades nucleic acid. 15. The cartridge of claim 1 wherein the body further comprises at least one reagent compartment comprising a reagent, wherein the compartment comprises an openable seal that, when opened, puts the compartment in fluidic communication through a via with a fluidic channel on the surface. 16. The cartridge of claim 1 wherein the body further comprises one or more reagent compartments comprising reagents including nucleic acid primers, nucleotides and DNA polymerases sufficient to perform PCR. 17. The cartridge of claim 16 wherein the reagents are sufficient for performing multiplex PCR on STR loci. 18. The cartridge of claim 1 wherein the deformable material has a durometer value of between 10 Shore D to 80 Shore D. 19. The cartridge of claim 1 wherein the deformable material comprises a heat seal material. 20. The cartridge of claim 1 wherein the deformable material comprises a material selected from polypropylene, polyethylene, polystyrene, cycloolefin co-polymer (COC), mylar, polyacetate and a metal. 21. The cartridge of claim 1 wherein a portion of the layer of deformable material covering a valve seat does not comprise an elastomeric material. 22. The cartridge of claim 1 wherein the layer of deformable material has a higher yield strength than the malleable material. 23. The cartridge of claim 1 wherein the deformable material is attached to the body through an adhesive. 24. The cartridge of claim 1 wherein the deformable material is welded to the body. 25. The cartridge of claim 1 further comprising a chamber comprising a filter. 26. The cartridge of claim 1 comprising elements of a fluidic circuit including a fluid inlet, a fluid outlet and at least three chambers, which elements are fluidically connected through fluidic channels, wherein each fluidic channel connecting two of the chambers comprises a valve body. 27. The cartridge of claim 1 comprising a branched fluidic circuit comprising chambers connected by fluidic channels and comprising a common portion and a plurality of branches, wherein the common portion comprises a fluid inlet and a lysis chamber, and wherein each branch comprises at least one reaction chamber comprising one or more thermally conductive walls and configured for thermal cycling, at least one isolation chamber and a fluid outlet, wherein at least the fluidic channels connecting a reaction chamber with an isolation chamber comprises a valve body. 28. The cartridge of claim 1 comprising reliefs depressed into the surface and defining depressions that flank the ridges on two sides of the segment of the channel. 29. The cartridge of claim 1 wherein the valve is configured to be closed by mechanical pressure from a ram forcing the layer against the floor of the segment of the channel.

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Yager Paul ; Brody James P., Absorption-enhanced differential extraction device.
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Chinn, Douglas A.; Irvin, David J., Actuator device utilizing a conductive polymer gel.
상세보기
Wolk Jeffrey A. ; McReynolds Richard J. ; Parce J. Wallace, Alignment of multicomponent microfabricated structures.
상세보기
Roach, David J.; Loder, Jr., Robert T.; Armstrong, Thomas M.; Harris, Dennis W.; Jovanovich, Stevan B.; Johnston, Richard F., Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis.
상세보기
Baer,Thomas M.; Smith,Thomas L.; Reamey,Robert H., Apparatus and method for heating microfluidic volumes and moving fluids.
상세보기
J. Michael Ramsey, Apparatus and method for performing microfluidic manipulations for chemical analysis.
상세보기
Ramsey J. Michael, Apparatus and method for performing microfluidic manipulations for chemical analysis.
상세보기
Ramsey J. Michael, Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis.
상세보기
D. Jed Harrison CA; Richard Oleschuk CA; Loranelle Shultz-Lockyear ; Cameron Skinner CA; Paul Li CA, Apparatus and method for trapping bead based reagents within microfluidic analysis systems.
상세보기
Harrison, D. Jed; Oleschuk, Richard; Lockyear, Loranelle L.; Skinner, Cameron; Li, Paul, Apparatus and method for trapping bead based reagents within microfluidic analysis systems.
상세보기
Harrison,D. Jed; Oleschuk,Richard; Shultz Lockyear,Loranelle; Skinner,Cameron; Li,Paul, Apparatus and method for trapping bead based reagents within microfluidic analysis systems.
상세보기
Turner,Stephen; Korlach,Jonas, Apparatus and methods for optical analysis of molecules.
상세보기
Weinberger,Scot R.; Hlousek,Louis, Apparatus for microfluidic processing and reading of biochip arrays.
상세보기
Eggers,Mitchell D., Apparatus, system, and method of archival and retrieval of samples.
상세보기
Michael Seul ; Alice Xiang Li, Array Cytometry.
상세보기
Balasubramanian,Shankar; Klenerman,David; Barnes,Colin; Osborne,Mark Allen, Arrayed biomolecules and their use in sequencing.
상세보기
Eggers, Mitchell D., Automated biological sample archive for storage, retrieval and analysis of large numbers of samples for remote clients.
상세보기
Laurence James B. ; Bartles Bruce ; Crosby Morris ; Wiggins Steve, Bag apparatus with reclosable pour spout.
상세보기
Shimizu, Yasushi; Kita, Toshiaki; Tsukada, Kiyoshi; Suzuki, Akihiro; Morioka, Tomonari; Kojima, Masaya; Inaba, Ryoji; Tokinaga, Daizo; Yamamoto, Shuhei; Okishima, Yoshiyuki; Fukunaga, Masao; Furukawa, Takayasu; Shoji, Tomohiro, Capillary array.
상세보기
Shimizu, Yasushi; Kita, Toshiaki; Tsukada, Kiyoshi; Suzuki, Akihiro; Morioka, Tomonari; Kojima, Masaya; Inaba, Ryoji; Tokinaga, Daizo; Yamamoto, Shuhei; Okishima, Yoshiyuki; Fukunaga, Masao; Furukawa, Takayasu; Shoji, Tomohiro, Capillary array.
상세보기
Shimizu,Yasushi; Kita,Toshiaki; Tsukada,Kiyoshi; Suzuki,Akihiro; Morioka,Tomonari; Kojima,Masaya; Inaba,Ryoji; Tokinaga,Daizo; Yamamoto,Shuhei; Okishima,Yoshiyuki; Fukunaga,Masao; Furukawa,Takayasu; , Capillary array.
상세보기
Ugai,Seiichi; Morioka,Tomonari; Inaba,Ryoji; Suzuki,Akihiro; Ookoshi,Yoshinori; Okishima,Yoshiyuki; Ohira,Tsukasa; Yamazaki,Motohiro; Gomi,Takashi, Capillary array and capillary electrophoresis apparatus.
상세보기
Hayashizaki, Yoshihide; Yamamoto, Rintaro, Capillary cassette and method of manufacturing the same.
상세보기
Paul, Carlton H., Capillary column chromatography process and system.
상세보기
Bjornson Torleif Ove ; McCormick Randy M. ; Soane David S., Capillary electroflow apparatus and method.
상세보기
Sakai,Tomoyuki; Anazawa,Takashi, Capillary electrophoresis apparatus.
상세보기
Majlof, Lars; Van Gelder, Ezra, Capillary electrophoresis device.
상세보기
Shoji,Tomihiro; Kojima,Masaya; Okishima,Yoshiyuki; Inaba,Ryoji, Capillary electrophoresis device.
상세보기
Yoshihide Hayashizaki JP; Hideshi Fujiwake JP; Shin Nakamura JP, Capillary electrophoretic apparatus.
상세보기
Hillman Robert S. (Cupertino CA) Cobb Michael E. (Sunnyvale CA) Allen Jimmy D. (Los Altos CA) Gibbons Ian (Menlo Park CA) Ostoich Vladimir E. (San Jose CA) Winfrey Laura J. (Belmont CA), Capillary flow device.
상세보기
Jovanovich Stevan B. ; Ronan Gregory J. ; Roach David J. ; Johnston Richard F., Capillary valve, connector, and router.
상세보기
Mark A. Burns ; David T. Burke ; Brian N. Johnson ; John D. DeNuzzio ; Wayne F. Beyer, Jr., Chip-based isothermal amplification devices and methods.
상세보기
Knapp Michael ; Parce John Wallace ; Bousse Luc J. ; Kopf-Sill Anne R., Closed-loop biochemical analyzers.
상세보기
Michael Knapp ; John Wallace Parce ; Luc J. Bousse ; Anne R. Kopf-Sill, Closed-loop biochemical analyzers.
상세보기
Law ; Gabriel H. ; Gysegem ; Albert Peter, Coatings prepared from trialkoxysilanes.
상세보기
Dittmann Monika,DEX ; Rozing Gerard,DEX ; Zimmermann Hans-Peter,DEX, Column for capillary chromatographic separations.
상세보기
Chee, Mark; Walt, David R., Combinatorial decoding of random nucleic acid arrays.
상세보기
Van Dam,Michael; Unger,Marc A.; Quake,Stephen R., Combinatorial synthesis system.
상세보기
Gent John A. G. (Hampshire GB2), Compositions and processes producing scratch resistant polysiloxane coatings.
상세보기
Parce John Wallace ; Knapp Michael R. ; Chow Calvin Y. H. ; Bousse Luc, Controlled fluid transport in microfabricated polymeric substrates.
상세보기
Parce John Wallace ; Knapp Michael R. ; Chow Calvin Y. H. ; Bousse Luc, Controlled fluid transport in microfabricated polymeric substrates.
상세보기
Nassef,Hany Ramez; Facer,Geoffrey; Barco,Joseph W., Crystal growth devices and systems, and methods for using same.
상세보기
Haarer Brian K. ; Atkinson Nigel S., DNA additives as a mechanism for unambiguously marking biological samples.
상세보기
Hawkins Trevor, DNA purification and isolation using magnetic particles.
상세보기
Hawkins Trevor, DNA purification and isolation using magnetic particles.
상세보기
Cantor Charles R. (Boston MA) Ito Takashi (Chiba MA JPX) Smith Cassandra L. (Boston MA), DNA purification by triplex-affinity capture and affinity capture electrophoresis.
상세보기
Caskey Charles T. (Houston TX) Edwards Albert O. (Houston TX), DNA typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats.
상세보기
Wilding,Peter; Kricka,Larry J.; Zemel,Jay N., Device and method for the detection of an analyte utilizing mesoscale flow systems.
상세보기
Griffin,Neil; Sutton,Nicki; Carmichael,Allan; Hyde,Sam Charles William; Somerville,John Matthew, Device for chemical or biochemical analysis.
상세보기
Hofmann, Martin; Spraul, Manfred; Godejohann, Marcus, Device for trapping at least one component of a chromatography flow in an LC/NMR environment.
상세보기
Kobrin, Boris; Blaga, Iuliu I.; Nielsen, William; Qi, Shize D.; Van Gelder, Ezra, Device with diaphragm valve.
상세보기
Chen,Yi Ju; Leamon,John H.; Lohman,Kenton L.; Ronan,Michael T.; Rothberg,Jonathan M.; Srinivasan,Maithreyan; Weiner,Michael P., Double ended sequencing.
상세보기
Evans, Robert F.; Burrow, Michael F., Drug delivery and monitoring system.
상세보기
Weekes, Stuart, Dual reamer driver.
상세보기
Boone, Travis, Efficient compound distribution in microfluidic devices.
상세보기
Yan Chao (1200 N. Queen St. ; #108 Arlington VA 22209), Electrokinetic packing of capillary columns.
상세보기
Imai, Kazumichi; Uchida, Osamu, Electrophoresis analysis apparatus and sample vessel used therefor.
상세보기
Guzman,Norberto A., Electrophoresis apparatus having staggered passage configuration.
상세보기
Shoji, Tomohiro; Okishima, Yoshiyuki; Kojima, Masaya; Maeshima, Muneo, Electrophoretic method and electrophoretic instrument therefor.
상세보기
Grate, Jay W.; Bruckner-Lea, Cynthia J.; Holman, David A., Flow-controlled magnetic particle manipulation.
상세보기
Mathies,Richard A.; Grover,William H.; Skelley,Alison; Lagally,Eric; Liu,Chung N., Fluid control structures in microfluidic devices.
상세보기
Moles Donald R., Fluid flow module.
상세보기
Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA) Zemel Jay N. (Jenkintown PA), Fluid handling methods for use in mesoscale analytical devices.
상세보기
Blaga, Iuliu I.; Jovanovich, Stevan B.; Kobrin, Boris; Van Gelder, Ezra, Fluidic devices with diaphragm valves.
상세보기
Barber, Rebecca A. L.; Barber, Michael D.; Johnson, Peter E.; Gillbard, Sharon M.; Haywood, Marc D.; Smith, Carolyn D.; Arnold, Jennifer A.; Burke, Trudy; Urquhart, Andrew J.; Gill, Peter P., Forensic identification.
상세보기
Griffiths,Rebecca A. L.; Barber,Michael D.; Johnson,Peter E.; Gillbard,Sharon M.; Haywood,Marc D.; Smith,Carolyn D.; Arnold,Jennifer A.; Burke,Trudy; Urquhart,Andrew J.; Gill,Peter P., Forensic identification.
상세보기
Swedberg Sally A. (Los Altos CA) Kaltenbach Patrick (Bischweier DEX) Witt Klaus E. (Keltern DEX) Bek Fritz (Waldbronn DEX) Mittelstadt Laurie S. (Belmont CA), Fully integrated miniaturized planar liquid sample handling and analysis device.
상세보기
Hashmi,Ghazala; Seul,Michael; Messing,Joachim, Genetic analysis and authentication.
상세보기
Sakurada,Masahiro; Fusegawa,Izumi; Soeta,Satoshi; Iida,Makoto, Graphite heater for producing single crystal, apparatus for producing single crystal, and method for producing single crystal.
상세보기
Korlach, Jonas; Webb, Watt W.; Levene, Michael; Turner, Stephen; Craighead, Harold G.; Foquet, Mathieu, High speed nucleic acid sequencing.
상세보기
Parce John Wallace ; Kopf-Sill Anne R. ; Bousse Luc J., High throughput screening assay systems in microscale fluidic devices.
상세보기
John Wallace Parce ; Anne Kopf-Sill ; Luc J. Bousse, High-throughput screening assay systems in microscale fluidic devices.
상세보기
Swartz,James Robert; Kim,Dong Myung, In vitro synthesis of polypeptides by optimizing amino acid metabolism.
상세보기
Mathies, Richard A.; Blazej, Robert; Kumaresan, Palani, Inline-injection microdevice and microfabricated integrated DNA analysis system using same.
상세보기
Stave, James W.; Teaney, III, George B.; Kroll, Werner, Integrated assay device and methods of production and use.
상세보기
Facer, Geoffrey; Grossman, Robert; Unger, Marc; Lam, Philip; Chou, Hou-Pu; Kimball, Jake; Pieprzyk, Martin; Daridon, Antoine, Integrated chip carriers with thermocycler interfaces and methods of using the same.
상세보기
Nelson Robert J. ; Hooper Herbert H. ; Landers James, Integrated electrophoretic microdevices.
상세보기
Roach, David John; Ni, Jing; Blaga, Iuliu-Ioan; Salv?n, Owe; Jovanovich, Stevan Bogdan, Integrated microchip design.
상세보기
Takayama, Shuichi; Zhu, Xiaoyue; Gu, Wei; Smith, Gary Daniel; Heo, Yunseok; Cho, Brenda S.; Futai, Nobuyuki, Integrated microfluidic control employing programmable tactile actuators.
상세보기
Nelson Robert J. ; Hooper Herbert H. ; Hauser Alan K. ; Sassi Alexander P., Integrated microfluidic devices.
상세보기
Edward S. Yeung ; Hongdong Tan, Integrated multiplexed capillary electrophoresis system.
상세보기
Tan, Eugene; Lam, Heung Chuan; Bogdanov, Valery Leonidovich; Kellogg, Gregory John; Wright, John A.; Thomann, Ulrich Hans; Selden, Richard F., Integrated nucleic acid analysis.
상세보기
Battrell, C. Frederick; Gerdes, John; Williford, John R.; Hoekstra, Denise Maxine; Breidford, Wayne L.; Mordue, Stephen; Clemmens, John; Nabavi, Melud; Kokoris, Mark, Integrated nucleic acid assays.
상세보기
Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
상세보기
Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
상세보기
Lipshutz Robert J. ; Rava Richard P. ; Anderson Rolfe C. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
상세보기
Apffel James A. ; Chakel John A. ; Hancock William S. ; Lichtenwalter Kay, Integrated planar liquid handling system for maldi-TOF MS.
상세보기
Jovanovich,Stevan B.; Blaga,Iuliu; McIntosh,Roger, Integrated system with modular microfluidic components.
상세보기
Karger Barry L. (Newton MA) Nelson Robert J. (Boston MA), Integrated temperature control/alignment system for high performance capillary electrophoretic apparatus.
상세보기
Barlow, David, Laminate.
상세보기
Bjornson, Torleif Ove; Shea, Laurence R., Laminate microstructure device and method for making same.
상세보기
Haase Donald A. (Penfield NY), Laminate of biaxially oriented polystyrene film and polystyrene foam.
상세보기
Brown, Richard B.; Martin, Steve M., Laminated devices and methods of making same.
상세보기
Stern, Seth; Jovanovich, Stevan Bogdan, Linear valve arrays.
상세보기
Stevan B. Jovanovich ; David J. Roach ; Andrew G. Hadd ; Bo E. R. Hellman, Low volume chemical and biochemical reaction system.
상세보기
Mehta, Tammy Burd; Kopf-Sill, Anne R.; Parce, J. Wallace; Chow, Andrea W.; Bousse, Luc J.; Knapp, Michael R.; Nikiforov, Theo T.; Gallagher, Steve, Manipulation of microparticles in microfluidic systems.
상세보기
Ramsey J. Michael ; Ramsey Roswitha S., Material transport method and apparatus.
상세보기
Hogan, Michael; Saghbini, Michael; Shi, Chunnian; Wong, David, Matrices and media for storage and stabilization of biomolecules.
상세보기
Hartman Michael G., Mechanism for providing motive force and for pumping applications.
상세보기
Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA), Mesoscale polynucleotide amplification devices.
상세보기
Wilding Peter ; Kricka Larry J., Mesoscale sample preparation device and systems for determination and processing of analytes.
상세보기
Cottingham Hugh V. (Caldwell NJ), Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay.
상세보기
Gjerde,Douglas T.; Hanna,Christopher P., Method and device for extracting an analyte.
상세보기
Soane David S. ; Soane Zoya M., Method and device for moving molecules by the application of a plurality of electrical fields.
상세보기
Perlin, Mark W., Method for DNA mixture analysis.
상세보기
Fukuzono, Shinichi, Method for analyzing nucleic acid.
상세보기
Soares Marcelo B. ; Efstratiadis Argiris, Method for construction of normalized cDNA libraries.
상세보기
Manz Andreas,CHX ; Harrison D. Jed,CAX ; Effenhauser Carlo S.,DEX, Method for controlling sample introduction in microcolumn separation techniques and sampling device.
상세보기
Cash,Howard; Mercer,Simon; Hoyle,Jonathon; Hadden,Lucy; Sutton,Amy; Relyea,David; Wake,William; Smith,Matthew; Kubit,Tom; Poth,Greg; Korn,Anna; Khizhnyak,Anna; Beeson,Tracy, Method for profiling and identifying persons by using data samples.
상세보기
Singhvi Rahul ; Kumar Amit ; Whitesides George M. ; Ingber Donald E. ; Lopez Gabriel P. ; Wang Daniel I. C. ; Stephanopoulos Gregory N., Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices an.
상세보기
Senapathy, Periannan, Method of genome-wide nucleic acid fingerprinting of functional regions.
상세보기
Unger, Marc A.; Chou, Hou-Pu; Thorsen, Todd A.; Scherer, Axel; Quake, Stephen R., Method of making a microfabricated elastomeric valve.
상세보기
Jovanovich, Stevan B.; Ronan, Gregory J.; Roach, David J.; Johnston, Richard F., Method of merging chemical reactants in capillary tubes.
상세보기
Rothberg,Jonathan M.; Bader,Joel S.; Dewell,Scott B.; McDade,Keith; Simpson,John W.; Berka,Jan; Colangelo,Christopher M., Method of sequencing a nucleic acid.
상세보기
Reeve Michael A. (Henley-on-Thames GB2), Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules.
상세보기
Adourian Aram S. ; Ehrlich Daniel J. ; Koutny Lance B. ; Matsudaira Paul T. ; Schmalzing Dieter R., Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device.
상세보기
Andy Hadd ; Stevan Jovanovich, Methods and apparatus for template capture and normalization for submicroliter reaction.
상세보기
Loehrlein, Christine; Pollart, Dan; Shaler, Thomas; Stephens, Kathy; Tan, Yuping; Wong, Linda; Monforte, Joseph, Methods for analysis of gene expression.
상세보기
Gunars E. Valkirs, Methods for concentrating ligands using magnetic particles.
상세보기
Soane David S. ; Soane Zoya M. ; Hooper Herbert H. ; Amigo M. Goretty Alonso, Methods for fabricating enclosed microchannel structures.
상세보기
Jacobson, Stephen C.; Ramsey, J. Michael; Culbertson, Christopher T.; Whitten, William B.; Foote, Robert S., Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels.
상세보기
Vangbo, Mattias; Nielsen, William D.; Blaga, Iuliu I.; Nguyen, Michael Van; Jovanovich, Steven B., Methods for generating short tandem repeat (STR) profiles.
상세보기
Bignell, Helen; Fraser, Louise; Gormley, Niall Anthony, Methods for indexing samples and sequencing multiple polynucleotide templates.
상세보기
Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan, Methods for processing and analyzing nucleic acid samples.
상세보기
Gill, Peter; Koumi, Peter; Tsang, Kam, Methods for setting up, monitoring and performing analysis using capillary gel arrays.
상세보기
Leamon, John H.; McDade, Keith E.; Fierro, Joseph M.; Knight, James R.; Charumilind, Jaran; Myers, Jr., Eugene W.; Simpson, John W.; Volkmer, Greg A., Methods of amplifying and sequencing nucleic acids.
상세보기
Leamon,John H.; Lohman,Kenton L.; Rothberg,Jonathan M.; Weiner,Michael P., Methods of amplifying and sequencing nucleic acids.
상세보기
Webster, James Russell, Micro valve actuator.
상세보기
Penterman, Roel; Van Eemeren, Johannes; Wimberger-Friedl, Reinhold; Van Amerongen, Hendrik, Micro-pump or normally-off micro-valve.
상세보기
Nielsen, Matthew C.; Meyer, Laura J.; Wetzel, Todd G.; Weaver, Stanton E.; Fortin, Jeffrey B.; Guida, Renato, Microelectromechanical high pressure gas microvalve.
상세보기
Marc A. Unger ; Hou-Pu Chou ; Todd A. Thorsen ; Axel Scherer ; Stephen R. Quake, Microfabricated elastomeric valve and pump systems.
상세보기
Unger, Marc A.; Chou, Hou-Pu; Thorsen, Todd A.; Scherer, Axel; Quake, Stephen R.; Enzelberger, Markus M.; Adams, Mark L.; Hansen, Carl L., Microfabricated elastomeric valve and pump systems.
상세보기
Unger, Marc A.; Chou, Hou-Pu; Thorsen, Todd A.; Scherer, Axel; Quake, Stephen R.; Liu, Jian; Adams, Mark L.; Hansen, Carl L., Microfabricated elastomeric valve and pump systems.
상세보기
Fernandes, David N.; Chou, Hou-Pu; Unger, Marc A., Microfabricated fluidic circuit elements and applications.
상세보기
Fernandes, David N.; Chou, Hou-Pu; Unger, Marc A., Microfabricated fluidic circuit elements and applications.
상세보기
Liu, Shaorong, Microfabricated injector and capillary array assembly for high-resolution and high throughput separation.
상세보기
Mathies, Richard A.; Blazej, Robert; Liu, Chung; Kumaresan, Palani; Yeung, Stephanie H. I., Microfabricated integrated DNA analysis system.
상세보기
Mathies, Richard A.; Blazej, Robert; Liu, Chung; Kumaresan, Palani; Yeung, Stephanie H. I., Microfabricated integrated DNA analysis system.
상세보기
Mathies, Richard A.; Emrich, Charles A.; Simpson, Peter C., Microfabricated liquid sample loading system.
상세보기
Webster, James Russell, Microfluidic actuator.
상세보기
Jovanovich, Stevan Bogdan; Blaga, Iuliu I.; Nguyen, Michael; Nielsen, William D.; Vangbo, Mattias, Microfluidic and nanofluidic devices, systems, and applications.
상세보기
Nelson, Robert J.; Hooper, Herbert H.; Hauser, Alan K.; Singh, Sharat; Williams, Stephen J.; Sassi, Alexander P., Microfluidic apparatus and method for purification and processing.
상세보기
Zhou, Peng; Young, Lincoln, Microfluidic chips and assay systems.
상세보기
Huang, Jiang; Chou, Hou-Pu; Unger, Marc A., Microfluidic chromatography.
상세보기
Huang,Jiang; Chou,Hou Pu; Unger,Marc A., Microfluidic chromatography.
상세보기
Victor ; Jr. Richard L. ; Stokes Jeffrey H., Microfluidic connector.
상세보기
Lee, Michael; Worthington, Gajus; Harris, Gregory; Montgomery, James, Microfluidic design automation method and system.
상세보기
Lee, Michael; Worthington, Gajus; Harris, Gregory; Montgomery, James, Microfluidic design automation method and system.
상세보기
Unger,Marc; Manger,Ian D.; Lucero,Michael; Yi,Yong; Miyashita Lin,Emily; Weinecke,Anja; Facer,Geoffrey, Microfluidic device and methods of using same.
상세보기
Kenis, Paul J. A.; Tice, Joshua D.; Perry, Sarah L.; Roberts, Griffin W., Microfluidic device for preparing mixtures.
상세보기
James, Conrad D.; Kumar, Anil; Khusid, Boris; Acrivos, Andreas, Microfluidic device for the assembly and transport of microparticles.
상세보기
Jovanovich, Stevan B.; Blaga, Iuliu I., Microfluidic devices.
상세보기
Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan, Microfluidic devices.
상세보기
Jedrzejewski,Paul; Nock,Steffen; Wagner,Peter; Indermuhle,Pierre; Zaugg,Frank G., Microfluidic devices and methods.
상세보기
Paul Jedrzejewski ; Steffen Nock ; Peter Wagner ; Pierre Indermuhle ; Frank G. Zaugg, Microfluidic devices and methods.
상세보기
Chou,Hou Pu; Fu,Anne Y.; Quake,Stephen R., Microfluidic devices and methods of use.
상세보기
Unger, Marc; Huang, Jiang; Quan, Emerson, Microfluidic devices and methods of using same.
상세보기
Dubrow Robert S. ; Kennedy Colin B. ; Nagle Robert, Microfluidic devices and systems incorporating cover layers.
상세보기
Fouillet,Yves; Vauchier,Claude; Clerc,Jean Frederic; Peponnet,Christine, Microfluidic devices and uses thereof in biochemical processes.
상세보기
Unger, Marc A.; Chou, Hou-Pu; Manger, Ian D.; Fernandes, Dave; Yi, Yong, Microfluidic devices for introducing and dispensing fluids from microfluidic systems.
상세보기
Ramsey, J. Michael; Jacobson, Stephen C., Microfluidic devices for the controlled manipulation of small volumes.
상세보기
Ganesan, Karthik, Microfluidic devices having a reduced number of input and output connections.
상세보기
Vangbo, Mattias, Microfluidic devices with mechanically-sealed diaphragm valves.
상세보기
Vangbo, Mattias, Microfluidic devices with mechanically-sealed diaphragm valves.
상세보기
Barenburg, Barbara Foley; Burdon, Jeremy; Chan, Yuk-Tong; Dai, Xunhu; Gallagher, Sean; Grodzinski, Piotr; Marrero, Robert; Nair, Vijay; Rhine, David; Smekal, Thomas, Microfluidic devices with monolithic microwave integrated circuits.
상세보기
Bryning,Zbigniew T.; Shigeura,John, Microfluidic devices, methods, and systems.
상세보기
Kornelsen, Kevin E., Microfluidic flow control device.
상세보기
Nelson Robert J. ; Hooper Herbert H. ; Hauser Alan K. ; Singh Sharat ; Williams Stephen J. ; Sassi Alexander P., Microfluidic method for nucleic acid purification and processing.
상세보기
Jovanovich, Stevan B.; Nielsen, William D.; Nguyen, Michael Van, Microfluidic methods.
상세보기
Clemmens, John; Battrell, C. Frederick; Gerdes, John; Hoekstra, Denise Maxine, Microfluidic mixing and analytic apparatus.
상세보기
Chou,Hou Pu; Daridon,Antoine; Farrell,Kevin; Fowler,Brian; Liau,Yish Hann; Manger,Ian D.; Nassef,Hany Ramez; Throndset,William, Microfluidic particle-analysis systems.
상세보기
Young, Lincoln; Zhou, Peng, Microfluidic pump and valve structures and fabrication methods.
상세보기
Jarvius, Jonas Sven Peter; Melin, Jonas, Microfluidic structure.
상세보기
Ekstrm Bjrn (Upsala SEX) Jacobson Gunilla (Upsala SEX) Ohman Ove (Upsala SEX) Sjdin Hakan (Upsala SEX), Microfluidic structure and process for its manufacture.
상세보기
Harrison, Daniel Jed; Andersson, Per; Li, Paul C. H.; Szarka, Roderick; Smith, Richard, Microfluidic system and methods of use.
상세보기
Handique, Kalyan; Brahmasandra, Sundaresh N.; Ganesan, Karthik; Williams, Jeff, Microfluidic system for amplifying and detecting polynucleotides in parallel.
상세보기
Zhou, Peng; Young, Lincoln, Microfluidic systems.
상세보기
Pezzuto,Marci; Dantsker,Eugene, Microfluidic systems and methods for combining discrete fluid volumes.
상세보기
Michael Knapp ; John Wallace Parce ; Luc J. Bousse ; Anne R. Kopf-Sill, Microfluidic systems and methods of genotyping.
상세보기
Kopf-Sill Anne R. ; Parce John Wallace, Microfluidic systems incorporating varied channel dimensions.
상세보기
Karger Barry L. ; Foret Frantisek ; Zavracky Paul M. ; McGruer E. Nicol ; Xue Qifeng ; Dunayevskiy Yuriy M., Microscale fluid handling system.
상세보기
Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Miniaturized genetic analysis systems and methods.
상세보기
Hasselbrink, Jr., Ernest F.; Rehm, Jason E.; Shepodd, Timothy J., Mobile monolithic polymer elements for flow control in microfluidic devices.
상세보기
Kong Dan-Cheng ; Rehkugler Richard A. ; Sexton Donald F., Multi-layer hermetically sealable film.
상세보기
Chow Calvin Y. H., Multi-layer microfluidic devices.
상세보기
Pentoney ; Jr. Stephen L. (Yorba Linda CA) Rakestraw David J. (Fremont CA), Multicapillary fluorescent detection system.
상세보기
Briscoe, Cynthia G.; Yu, Huinan; Grodzinski, Piotr; Marrero, Robert; Burdon, Jeremy W.; Huang, Rong-Fong, Multilayered microfluidic DNA analysis system and method.
상세보기
Yager Paul, Multiple analyte diffusion based chemical sensor.
상세보기
Dau, Peter C.; Liu, Debang, Multiplex amplification and analysis of selected STR loci.
상세보기
Cong, Peijun; Doolen, Robert D., Multiplexed capillary electrophoresis system with rotatable photodetector.
상세보기
Mathies, Richard A.; Grover, William H.; Jensen, Erik C., Multiplexed latching valves for microfluidic devices and processors.
상세보기
Enzelberger, Markus M.; Liu, Jian; Quake, Stephen R., Nucleic acid amplification utilizing microfluidic devices.
상세보기
Gerdes,John C.; Marmaro,Jeffery M.; Ives,Jeffrey T.; Roehl,Christopher A., Nucleic acid archiving.
상세보기
Langmore, John P.; Markarov, Vladimir L., Nucleic acid sequencing and mapping.
상세보기
Harris, Gregory; Montgomery, James; Lee, Michael; Worthington, Gajus, Object oriented microfluidic design method and system.
상세보기
Nguyen, Michael; Bousse, Luc, Optimized sample injection structures in microfluidic separations.
상세보기
Southgate Peter David ; Andrevski Zygmunt Marian ; Roach William Ronald ; Zanzucchi Peter John, Parallel reaction cassette and associated devices.
상세보기
Rice Alan R. (16 Falcon Ter. Wylam ; Northumberland GB2), Pile-driving apparatus.
상세보기
Huang,Jiang; Xiao,Shoujun; Unger,Marc A., Polymer surface modification.
상세보기
Mastrangelo Carlos H. ; Man Piu F. ; Webster James R., Polymer-based micromachining for microfluidic devices.
상세보기
Nasarabadi, Shanavaz, Polymerase chain reaction system using magnetic beads for analyzing a sample that includes nucleic acid.
상세보기
Solus,Joseph; Yang,Shuwei; Chatterjee,Deb K, Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof.
상세보기
Madabhushi, Ramakrishna S.; Menchen, Steven M.; Efcavitch, J. William; Grossman, Paul D., Polymers for separation of biomolecules by capillary electrophoresis.
상세보기
Balasubramanian, Shankar, Polynucleotide sequencing.
상세보기
Ternoir Leonard R. (Brea CA) Foscante Raymond E. (Yorba Linda CA) Gasmena Roland L. (Anaheim CA), Polysiloxane coating.
상세보기
Reeve Michael Alan (Henley-on-Thames GB3), Precipitating polymers.
상세보기
Wu Annie L. (Penfield NY), Preparation and isolation of single-stranded biotinylated nucleic acids by heat avidin-biotin cleavage.
상세보기
Nazarenko, Irina; Rashtchian, Ayoub, Primers and methods for the detection and discrimination of nucleic acids.
상세보기
Campbell, Adrian M.; Dumitrescu, Nicolae, Reagent cartridge.
상세보기
Nova Michael P. ; Senyei Andrew E., Remotely programmable matrices with memories.
상세보기
Thrall Ronald G. ; Freeman James M. ; Piper Wayne C., Resealable closure for a bag.
상세보기
Roach, David J.; Loder, Jr., Robert T.; Armstrong, Thomas M.; Harris, Dennis W.; Jovanovich, Stevan B.; Johnston, Richard F., Robotic microchannel bioanalytical instrument.
상세보기
Roach, David J.; Loder, Jr., Robert T.; Armstrong, Thomas M.; Harris, Dennis W.; Jovanovich, Stevan B.; Johnston, Richard F., Robotic microchannel bioanalytical instrument.
상세보기
Nurse, James C.; Greiner, Douglas P.; Beard, Nigel P., Sample distribution devices and methods.
상세보기
Nielsen, William D.; Belcinski, Richard J.; Bogdan, Gregory; Eberhart, David; El-Sissi, Omar; Jovanovich, Stevan B.; Recknor, Michael; Van Gelder, Ezra; Wyrick, David W., Sample preparation, processing and analysis systems.
상세보기
Bedingham, William; Rajagopal, Raj; Seshadri, Kannan, Sample processing device with integral electrophoresis channels.
상세보기
Bedingham, William; Carter, Chad J.; Harkins, Robert A.; Harms, Michael R.; Kokaisel, Christopher R.; North, Diane; Wood, Kenneth B., Sample processing devices and carriers.
상세보기
Mori, Masatomo; Eguchi, Hiroshi, Screening GPR12 receptor for substances having Nesfatin-1-like action, or which regulate Nesfatin-1 action.
상세보기
Davis, James C.; Eggers, Mitchell D.; Sadler, John W., Sealed sample storage element system and method.
상세보기
Davies, Brady Reuben, Selective bonding for forming a microvalve.
상세보기
Hobbs, Steven E.; Gregori, Matthew M.; Karp, Christoph D.; Koehler, Jeffrey A.; Patel, Paren P.; Covington, Joseph F., Separation column devices and fabrication methods.
상세보기
Parce,J. Wallace; Nikiforov,Theo T.; Mehta,Tammy Burd; Kopf Sill,Anne R.; Chow,Andrea W.; Knapp,Michael R., Sequencing by incorporation.
상세보기
John B. Schutt, Silane-based, coating compositions, coated articles obtained therefrom and methods of using same.
상세보기
Northrup M. Allen (Berkeley CA) Mariella ; Jr. Raymond P. (Danville CA) Carrano Anthony V. (Livermore CA) Balch Joseph W. (Livermore CA), Silicon-based sleeve devices for chemical reactions.
상세보기
Staub Rick W. ; Carrico Michael G., Simple and complex tandem repeats with DNA typing method.
상세보기
Weigl Bernhard H. ; Holl Mark R. ; Zebert Diane ; Kenny Margaret ; Wu Caicai, Simultaneous analyte determination and reference balancing in reference T-sensor devices.
상세보기
Shartle Robert J. (Livermore CA) Dubrow Robert S. (San Carlos CA), Single use separation cartridge for a capillary electrophoresis instrument.
상세보기
McKernan, Kevin; McEwan, Paul; Morris, William, Solid phase technique for selectively isolating nucleic acids.
상세보기
Hogan, Michael; Davis, James C., Stable protein storage and stable nucleic acid storage in recoverable form.
상세보기
Hogan, Michael; Davis, James C., Stable protein storage and stable nucleic acid storage in recoverable form.
상세보기
Foquet,Mathieu; Peluso,Paul; Turner,Stephen; Roitman,Daniel Bernardo; Otto,Geoffrey, Substrates for performing analytical reactions.
상세보기
Amigo M. Goretty Alonso ; McCormick Randy M., Surface modified electrophoretic chambers.
상세보기
Hodge,Timothy A., Systems and methods for transgenic and targeted mutagenesis screening.
상세보기
McBride, Lincoln; Facer, Geoffrey; Unger, Marc; Lucero, Michael; Nassef, Hany Ramez, Thermal reaction device and method for using the same.
상세보기
Bahatt, Dar; Patel, Chirag; Prothro, Derek K.; Tan, Roy H., Two-dimensional spectral imaging system.
상세보기
Rosenblum,Barnett B.; Jeon,Geun Sook; Khan,Shaheer H., Universal nucleotides for nucleic acid analysis.
상세보기
Jovanovich, Stevan B.; Nielsen, William D.; Cohen, David S.; Recknor, Michael; Vangbo, Mattias; Van Gelder, Ezra; El-Sissi, Omar, Universal sample preparation system and use in an integrated analysis system.
상세보기
Jovanovich, Stevan B.; Nielsen, William D.; Cohen, David S.; Recknor, Michael; Vangbo, Mattias; Van Gelder, Ezra; Majlof, Lars; El-Sissi, Omar, Universal sample preparation system and use in an integrated analysis system.
상세보기
Jovanovich, Stevan B.; Nielsen, William D.; Cohen, David S.; Recknor, Michael; Vangbo, Mattias; Van Gelder, Ezra; Majlof, Lars; El-Sissi, Omar, Universal sample preparation system and use in an integrated analysis system.
상세보기
Jovanovich, Stevan B.; Nielsen, William D.; Vangbo, Mattias; Van Gelder, Ezra; El-Sissi, Omar, Universal sample preparation system and use in an integrated analysis system.
상세보기
Pan Jeffrey Y. ; Lee Donald Ver, Valve control.
상세보기
Williams, Clinton L., Valve for use in microfluidic structures.
상세보기
Jeon, Noo Li; Chiu, Daniel T.; Wargo, Christopher J.; Choi, Insung S.; Wu, Hongkai; Anderson, Janelle R.; Whitesides, George M.; McDonald, J. Cooper; Metallo, Steven J.; Stone, Howard A., Valves and pumps for microfluidic systems and method for making microfluidic systems.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Fluidic cartridge with valve mechanism 원문보기

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대표청구항 ▼

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연합인증

Fluidic cartridge with valve mechanism 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

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