A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir
A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.
대표청구항▼
1. A method for delivering a bioactive agent to a user, the method comprising: connecting a reusable part of a delivery system to a disposable part of the delivery system;during the connecting step, compressing a first spring extending from an agent reservoir of the disposable part to pressurize the
1. A method for delivering a bioactive agent to a user, the method comprising: connecting a reusable part of a delivery system to a disposable part of the delivery system;during the connecting step, compressing a first spring extending from an agent reservoir of the disposable part to pressurize the bioactive agent within the agent reservoir;actuating a valve driver in the reusable part to move a valve in the disposable part to a first position to transfer the bioactive agent from the agent reservoir to a bolus chamber;actuating the valve driver to move the valve to a second position to transfer the bioactive agent from the bolus chamber to an agent outlet; andcompressing a second spring extending from the bolus chamber to pressurize the bioactive agent within the bolus chamber. 2. The method of claim 1 wherein the disposable part comprises a transdermal patch communicating with the agent outlet, the method further including transferring the bioactive agent from the bolus chamber to the transdermal patch. 3. The method of claim 2 wherein the disposable part further comprises a solvent recovery chamber, the bioactive agent being dissolved in a solvent in a liquid phase, the method further comprising receiving the solvent in a gaseous phase from the transdermal patch in the solvent recovery chamber. 4. The method of claim 3 wherein the disposable part further comprises a vapor permeable membrane, the receiving step comprising passing the solvent in the gaseous phase through the vapor permeable membrane into the solvent recovery chamber. 5. The method of claim 2 wherein the transdermal patch comprises a polypropylene membrane with a plurality of pores having an average pore diameter of about 0.02 μm to about 0.10 μm. 6. The method of claim 1 wherein the bioactive agent is dissolved in a solution comprising alcohol and water in a ratio of alcohol to water of about 40:60 to about 60:40. 7. The method of claim 1 wherein the delivery system further comprises a piston movably disposed in the bolus chamber, the method further comprising moving the piston with the second spring to move the bioactive agent from the bolus chamber to the agent outlet. 8. The method of claim 1 wherein the second spring is compressed during the connecting step. 9. The method of claim 1 wherein the second spring is compressed when the bioactive agent is transferred from the agent reservoir into the bolus chamber. 10. The method of claim 1 wherein the valve rotates between 60° to 90°, inclusive, during the actuating steps. 11. The method of claim 1 further comprising, during or after the connecting step, providing an indication to a remote device that the disposable part has been connected to the reusable part. 12. The method of claim 1 further comprising generating an indication that the disposable part needs to be replaced. 13. The method of claim 12 wherein the generating step comprises monitoring time elapsed after connecting the disposable part to the reusable part and providing the indication that the disposable part needs to be replaced after a predetermined time. 14. The method of claim 1 further comprising receiving an input from the user on the reusable part indicating that the user is experiencing a craving. 15. The method of claim 14 further comprising wirelessly transmitting an indication of the input to a remote device. 16. The method of claim 15 further comprising receiving a wireless signal indicating a psychological support in response to the input from the user indicating the craving. 17. The method of claim 1, wherein the bioactive agent is moved through the valve when transferring from the agent reservoir to the bolus chamber and when transferring from the bolus chamber to the agent outlet. 18. The method of claim 1, wherein the step of actuating a valve driver in the reusable part to move a valve in the disposable part to a first position to transfer the bioactive agent from the agent reservoir to a bolus chamber is performed after the step of connecting a reusable part of a delivery system to a disposable part of the delivery system, and wherein the bioactive agent transferred from the agent reservoir to the bolus chamber is the pressurized bioactive agent. 19. The method of claim 1, wherein the delivery system further comprises a piston movably disposed in the agent reservoir, the method further comprising moving the piston with the spring to move the bioactive agent from the agent reservoir to the bolus chamber. 20. A method for delivering a bioactive agent to a user, the method comprising: connecting a reusable part of a delivery system to a disposable part of the delivery system;during the connecting step, compressing a first spring extending from an agent reservoir of the disposable part to pressurize the bioactive agent within the agent reservoir;actuating a valve driver in the reusable part to move a valve in the disposable part to a first position, wherein moving the valve to the first position allows the spring to force the bioactive agent from the agent reservoir to a bolus chamber;actuating the valve driver to move the valve to a second position to transfer the bioactive agent from the bolus chamber to an agent outlet; andcompressing a second spring extending from the bolus chamber to pressurize the bioactive agent within the bolus chamber. 21. The method of claim 20 wherein the disposable part comprises a transdermal patch communicating with the agent outlet, the method further including transferring the bioactive agent from the bolus chamber to the transdermal patch. 22. The method of claim 20 wherein the delivery system further comprises a piston movably disposed in the bolus chamber, the method further comprising moving the piston with the second spring to move the bioactive agent from the bolus chamber to the agent outlet. 23. The method of claim 20 wherein the second spring is compressed during the connecting step. 24. The method of claim 20 wherein the second spring is compressed when the bioactive agent is transferred from the agent reservoir into the bolus chamber. 25. The method of claim 20 wherein the valve rotates between 60° to 90°, inclusive, during the actuating steps. 26. The method of claim 20 further comprising, during or after the connecting step, providing an indication to a remote device that the disposable part has been connected to the reusable part. 27. The method of claim 20 further comprising generating an indication that the disposable part needs to be replaced. 28. The method of claim 27 wherein the generating step comprises monitoring time elapsed after connecting the disposable part to the reusable part and providing the indication that the disposable part needs to be replaced after a predetermined time. 29. The method of claim 20 further comprising receiving an input from the user on the reusable part indicating that the user is experiencing a craving. 30. The method of claim 29 further comprising receiving a wireless signal indicating a psychological support in response to the input from the user indicating the craving. 31. The method of claim 20, wherein bioactive agent is moved through the valve when transferring from the agent reservoir to the bolus chamber and when transferring from the bolus chamber to the agent outlet.
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Hall Bonnie J. (Mason OH) Baur Julie A. (Fairfield OH) Deckner George E. (Cincinnati OH), Dermatological compositions and method of treatment of skin lesions therewith using benzoyl peroxide and tocopherol este.
Fallon Renee A. (Sunnyvale CA) Wilson Donald R. (San Francisco CA), Device for administering drug transdermally which provides an initial pulse of drug.
Lattin Gary A. (Forest Lake MN) Dickson Dale A. (Fridley MN) Grace Michael J. (Coon Rapids MN), Electrotransport agent delivery device having a disposable component and a removable liner.
Morita,Toshio; Inoue,Hitoshi; Nishimura,Kunio; Suhara,Yutaka; Ohshima,Satoshi; Yumura,Motoo, Fine carbon fiber, method for producing the same and electrically conducting material comprising the fine carbon fiber.
Shell John W. ; Louie-Helm Jenny, Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter.
Orr,Kevin H.; Mankaruse,George S.; Asaria,Ali, Handheld electronic device including vibrator having different vibration intensities and method for vibrating a handheld electronic device.
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Behar Albert (Reston VA) Behar Orna (Reston VA) Frederiksen Lee W. (McLean VA) Howard-Link Donald A. (Columbia MD) Timmerman Catherine (Washington DC), Human behavior modification which establishes and generates a user adaptive withdrawal schedule.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Weinzierl, David A., Medicament delivery device having an electronic circuit system.
Rose Jed E. (907 Kimball Dr. Durham NC 27705) Jarvik Murray E. (2001 Georgina Avenue Santa Monica CA 90402) Rose Karce D. (4050 W. Soda Rock Dr. Healdsburg CA 95448), Method and apparatus for aiding in the reduction of incidence of tobacco smoking.
Rose Jed E. (Venice CA) Jarvik Murray E. (Santa Monica CA) Rose Karce D. (Healdsburg CA), Method and apparatus for aiding in the reduction of incidence of tobacco smoking.
Segel Joseph M. ; Samuelson Michael H., Method and system for stopping or modifying undesirable health-related behavior habits or maintaining desirable health-.
Cormier Michel J. N. (Palo Alto CA) Ledger Philip W. (Mountain View CA) Amkraut Alfred (Palo Alto CA) Marty Jean P. (Sceaux FRX), Method for reducing sensitization or irritation in transdermal drug delivery and means therefor.
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Peter Anthony Crooks ; Haeil Park KR; Balwinder Singh Bhatti ; William Scott Caldwell ; Gary Maurice Dull, Pharmaceutical compositions and methods for use.
Roberts Josephine A. (7509 Ben Avon Rd. Bethesda MD 20817) Burwell Jephthae W. (3119 Adams Mill Rd. ; NW. Washington DC 20010), Positive-pressure ventilator system with controlled access for nebulizer component servicing.
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Wong Patrick S. L. ; Dong Liang-Chang ; Edgren David E. ; Theeuwes Felix ; Gardner Phyllis I. ; Jao Francisco ; Wan Jason J., Prolonged release active agent dosage form adapted for gastric retention.
Ledger Philip W. (Mountain View CA) Cormier Michel J. (Mountain View CA) Amkraut Alfred (Palo Alto CA), Reduction or prevention of sensitization to drugs.
Cormier Michel J-N (Mountain View CA) Ledger Philip W. (Mountain View CA) Amkraut Alfred (Palo Alto CA), Reduction or prevention of skin irritation by drugs.
Cormier Michel (Mountain View CA) Amkraut Alfred (Palo Alto CA) Ledger Philip W. (Bedford GBX), Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensiti.
Fern Ove B. (Helsingborg SEX) Helgertz Stig K. A. (Helsingborg SEX) Ohlsson Corfitz B. I. (Helsingborg SEX), Smoking substitutes for nasal administration-I.
Osborne James L. (Mountain View CA) Nelson Melinda (Sunnyvale CA) Enscore David J. (Saratoga CA) Yum Su I. (Los Altos CA) Gale Robert M. (Los Altos CA), Subsaturated nicotine transdermal therapeutic system.
Currie, John F.; Paranjape, Makarand; Peck, Carl C.; White, Robert; Schneider, Thomas W., Systems and methods for monitoring health and delivering drugs transdermally.
Gale, Robert M.; Stein, Thomas M.; Audett, Jay; Stepic, Jane; Phipps, Joseph B.; Cormier, Michel J. N., Transdermal analgesic systems with reduced abuse potential.
Haak Ronald P. (Menlo Park CA) Theeuwes Felix (Los Altos Hills CA) Gyory J. Richard (San Jose CA) Lattin Gary A. (Forest Lake MN), Transdermal delivery device.
Bello Gastone P. (Monmouth Beach NJ) Lyle John W. (Belmar NJ) Johnson Donald A. (Sea Girt NJ), Transdermal drug delivery device and method for its manufacture.
Fallon Renee A. (Sunnyvale CA) Venkatraman Subbu S. (Palo Alto CA) Cleary Gary W. (San Mateo CA), Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset.
Venktrama Subbu S. (Palo Alto CA) Fallon Renee A. (Sunnyvale CA) Cleary Gary W. (San Mateo CA), Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset.
Govil Sharad K. (Plantation FL) Rudnic Edward M. (Boca Raton FL) Sterner Dale G. (Pembroke Pines FL), Transdermal nitroglycerin patch with penetration enhancers.
Quan Danyi (Salt Lake City UT) Deshpanday Ninad A. (Salt Lake City UT) Venkateshwaran Srinivasan (Salt Lake City UT) Ebert Charles D. (Salt Lake City UT), Triacetin as a penetration enhancer for transdermal delivery of a basic drug.
Kang, Sewon; Fisher, Gary J.; Voorhees, John J., Use of natural EGFR inhibitors to prevent side effects due to retinoid therapy, soaps, and other stimuli that activate the epidermal growth factor receptor.
Heiber Werner (Bedford Hills NY) Andriola Robert (Putnam Valley NY) Williams Paul (Fairlawn NJ) Ebert Charles (Redwood City CA), User-activated transdermal therapeutic system.
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