Constructs and libraries comprising antibody surrogate light chain sequences
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07K-016/10
C07K-016/00
C07K-014/705
C07K-016/18
C07K-016/22
C07K-016/24
C40B-040/10
출원번호
US-0047301
(2013-10-07)
등록번호
US-10214580
(2019-02-26)
발명자
/ 주소
Bhatt, Ramesh
Horowitz, Lawrence
Xu, Li
출원인 / 주소
I2 PHARMACEUTICALS, INC.
대리인 / 주소
Cooley LLP
인용정보
피인용 횟수 :
0인용 특허 :
59
초록▼
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and l
The invention concerns constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention concerns constructs comprising VpreB sequences, optionally partnered with another polypeptide, such as, for example, antibody heavy chain variable domain sequences, and libraries containing the same.
대표청구항▼
1. A tetrameric construct comprising: (a) a first and a second surrogate light chain fusion polypeptide, each comprising the amino acid sequence of SEQ ID NO: 10, and;(b) a first and a second antibody heavy chain polypeptide comprising, from N-terminus to C-terminus, a heavy chain variable region (V
1. A tetrameric construct comprising: (a) a first and a second surrogate light chain fusion polypeptide, each comprising the amino acid sequence of SEQ ID NO: 10, and;(b) a first and a second antibody heavy chain polypeptide comprising, from N-terminus to C-terminus, a heavy chain variable region (VH), a heavy chain first constant region (CH1), a hinge region, a heavy chain second constant region (CH2), and a heavy chain third constant region (CH3), wherein each antibody heavy chain polypeptide comprises the amino acid sequence of SEQ ID NO: 9,wherein the first surrogate light chain fusion polypeptide is non-covalently conjugated to the first antibody heavy chain polypeptide, wherein the second surrogate light chain fusion polypeptide is non-covalently conjugated to the second antibody heavy chain polypeptide, and wherein the construct is capable of specifically binding to a target, wherein the target is an influenza A virus. 2. A tetrameric construct comprising: (a) a first and a second surrogate light chain fusion polypeptide, each comprising the amino acid sequence of SEQ ID NO: 10, and;(b) a first and a second antibody heavy chain polypeptide comprising, from N-terminus to C-terminus, a heavy chain variable region (VH), a heavy chain first constant region (CH1), a hinge region, a heavy chain second constant region (CH2), and a heavy chain third constant region (CH3), wherein each antibody heavy chain polypeptide comprises the amino acid sequence of SEQ ID NO: 14,wherein the first surrogate light chain fusion polypeptide is non-covalently conjugated to the first antibody heavy chain polypeptide, wherein the second surrogate light chain fusion polypeptide is non-covalently conjugated to the second antibody heavy chain polypeptide, and wherein the construct is capable of specifically binding to a target, wherein the target is an influenza A virus.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (59)
Akimoto Hiroshi (Kobe JPX) Kawai Akiyoshi (Kobe JPX), 4,5-Deoxymaytansinoids, their use and pharmaceutical compositions thereof.
Zhao, Robert Yongxin; Miller, Michael Louis; Widdison, Wayne Charles; Chari, Ravi V. J., Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same.
Chari Ravi J. (Boston MA) Goldmacher Victor S. (Newton Center MA) Lambert John M. (Cambridge MA) Blattler Walter A. (Brookline MA), Cytotoxic agents comprising maytansinoids and their therapeutic use.
Chari Ravi J. (Boston MA) Goldmacher Victor S. (Newton Center MA) Lambert John M. (Cambridge MA) Blattler Walter A. (Brookline MA), Cytotoxic agents comprising maytansinoids and their therapeutic use.
La Zor Clair G. (13054 Rose St. Cerritos CA 90701), Instrument for locating faults in aircraft passenger reading light and attendant call control system.
Kraus Matthias H. (Bethesda MD) Aaronson Stuart A. (Vienna VA), Isolated polypeptide erbB-3, related to the epidermal growth factor receptor and antibody thereto.
Low Philip S. (West Lafayette IN) Horn Mark A. (West Lafayette IN) Heinstein Peter F. (West Lafayette IN), Method for enhancing transmembrane transport of exogenous molecules.
Loughrey Helen C. (Vancouver CAX) Cullis Pieter R. (Vancouver CAX) Bally Marcel B. (Bowen Island CAX) Choi Lewis S. (Burnaby CAX), Method for protein-liposome coupling.
Freedman Bernard (Peoria IL) Powell Richard G. (Peoria IL) Smith ; Jr. Cecil R. (Dunlap IL), Method of controlling the European corn borer with trewiasine.
Steeves, Rita M.; Chari, Ravi V. J.; Blattler, Walter A., Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates.
McKinnon ; Jr. Charles N. (Laguna Niguel CA) Peterson Steven F. (West Linn OR) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection device.
Peterson Steven F. (West Linn OR) McKinnon ; Jr. Charles N. (Laguna Niguel CA) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection methods and device.
Bauer Steven R. (Birsfelden CHX) Kudo Akira (Basel CHX) Melchers Georg F. (Grenzach DEX) Sakaguchi Nobuo (Saga JPX), Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor.
Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences.
Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Gelfand David H. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme.
Carlsson Jan P. E. (Upsala SEX) Axn Rolf E. A. V. (Blinge SEX) Drevin Hakan N. Y. (Brunna SEX) Lindgren Gran E. S. (Almunge SEX), Pyridine compounds modifying proteins, polypeptides or polysaccharides.
Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
Eppstein Deborah A. (Los Altos CA) Fraser-Smith Elizabeth B. (Los Altos CA) Matthews Thomas R. (Los Gatos CA), Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.
Willner David (Hamden CT) Trail Pamela A. (Farmington CT) King H. Dalton (Hamden CT) Hofstead Sandra J. (Middletown CT) Greenfield Robert S. (Wallingford CT) Braslawsky Gary R. (Glastonbury CT), Thioether conjugates.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.