Composition and method for using medicament for endodontic irrigation, stem cell preparation and tissue regeneration
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-006/00
A61C-005/50
A61C-005/40
출원번호
US-0627760
(2017-06-20)
등록번호
US-10226403
(2019-03-12)
발명자
/ 주소
Dukoff, Amy
출원인 / 주소
Dukoff, Amy
대리인 / 주소
O'Rourke, Thomas A.
인용정보
피인용 횟수 :
0인용 특허 :
2
초록▼
A composition for tissue degradation and removal and disinfection is provided for dental and medical applications. It can function as a single intra-canal irrigant that eradicates microorganisms as it facilitates the debridement of a root canal system. It contains one or more hydoxides, a thioglycol
A composition for tissue degradation and removal and disinfection is provided for dental and medical applications. It can function as a single intra-canal irrigant that eradicates microorganisms as it facilitates the debridement of a root canal system. It contains one or more hydoxides, a thioglycolate compound, sodium hypochlorite, sodium chloride, sodium chlorate, oxygen, and water, such as lime water and purified water, The thioglycolate compound is capable of degrading a cell by disrupting disulfide bonds in its proteins. The sodium hypochlorite enhances its function. The composition may also incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, lanolin, and/or ceteareth-20. It is effective against Enterococcus faecalis.
대표청구항▼
1. A method of treating a patient, which comprises the steps of: (a) irrigating a pulpal cavity of a tooth with a composition, said composition comprising a thioglycolate, sodium hypochlorite, sodium chloride, oxygen, sodium chlorate, calcium hydroxide, and purified water; and(b) removing pulpal tis
1. A method of treating a patient, which comprises the steps of: (a) irrigating a pulpal cavity of a tooth with a composition, said composition comprising a thioglycolate, sodium hypochlorite, sodium chloride, oxygen, sodium chlorate, calcium hydroxide, and purified water; and(b) removing pulpal tissue from the pulpal cavity. 2. The method according to claim 1, wherein the step of irrigating the pulpal cavity includes flowing the composition into the pulpal cavity. 3. The method according, to claim 2, further comprising the step of providing a syringe having a barrel at least partially filled with the composition, wherein flowing the composition into the pulpal cavity includes expelling the composition from the syringe through an endodontic irrigation needle or syringe tip into the pulpal cavity. 4. The method according to claim 1, wherein the step of irrigating the pulpal cavity includes coating a portion of a medical instrument with the composition and inserting the coated portion into the pulpal cavity. 5. The method according to claim 1, wherein the composition is adapted to disrupt a disulfide bond in at least one of the pulpal tissue and a microbe. 6. The method according to claim 1, wherein irrigating the pulpal cavity comprises degrading the pulpal tissue, thereby facilitating the step of removing the pulpal tissue from the pulpal cavity. 7. The method according to claim 1, wherein the composition further comprises at least one additional compound selected from the group consisting of sodium hydroxide, fragrance, lanolin, mineral oil urea, ceteryl alcohol and ceteareth-20. 8. The method according to claim 7, wherein the hydroxide is present in the composition in an amount effective to deprotonate at least one of the thioglycolate and a biomolecule present in a soft tissue. 9. The method according, to claim 1, wherein said composition is made by mixing potassium thioglycolate, sodium hypochlorite and calcium hydroxide with water to form an aqueous mixture and wherein, at least initially on formation, said aqueous mixture contains from about 0.2% to about 6% by weight of sodium hypochlorite, from about 0.05% to about 2% by weight of potassium thioglycolate, and about 0.010 to about 0.005% by weight of calcium hydroxide.
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이 특허에 인용된 특허 (2)
Carpenter Richard S. (Cincinnati OH) Lad Pushkaraj J. (San Mateo CA) Wolff Ann M. (Cincinnati OH), Antimicrobial composition containing Type II endoglycosidase and antimicrobial agent.
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