In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophob
In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt % tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt % polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1-20 wt % of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt % of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.
대표청구항▼
1. A method for treating a urological condition, comprising: providing a transdermal patch comprising an adhesive matrix comprised of polyisobutylene, a solvent selected from dimethylacetamide, n-methylpyrrolidone and dimethylsulfoxide, a mixture of an unsaturated fatty acid and an alpha-hydroxy aci
1. A method for treating a urological condition, comprising: providing a transdermal patch comprising an adhesive matrix comprised of polyisobutylene, a solvent selected from dimethylacetamide, n-methylpyrrolidone and dimethylsulfoxide, a mixture of an unsaturated fatty acid and an alpha-hydroxy acid, a permeation enhancer of the formula CH3(CH2)mOCOCHR1R2, where m is an integer in the range of 6 to 14, R1 and R2 are each independently selected from hydrogen, hydroxyl, and a C1-C2 lower alkyl group, wherein at least one of R1 and R2 is hydroxyl or both R1 and R2 are hydrogen, and tamsulosin; andadministering or instructing to administer the transdermal patch. 2. The method of claim 1, wherein the solvent is dimethylsulfoxide. 3. The method of claim 2, wherein the adhesive matrix comprises dimethylsulfoxide and tamsulosin in a weight ratio of at least 1.2. 4. The method of claim 1, wherein the adhesive matrix comprises a molar ratio of alpha-hydroxy acid to tamsulosin of at least 0.1. 5. The method of claim 1, wherein the unsaturated fatty acid is selected from the group consisting of oleic acid, linoleic acid, and linolenic acid. 6. The method of claim 1, wherein the unsaturated fatty acid is a fatty acid with 11 to 21 carbon atoms. 7. The method of claim 1, comprising at least about 40 wt % polyisobutylene. 8. The method of claim 1, wherein the permeation enhancer is present at about 1-20 wt %. 9. The method of claim 1, wherein the permeation enhancer is either methyl laurate or lauryl lactate. 10. The method of claim 1, wherein tamsulosin is tamsulosin base. 11. The method of claim 1, wherein the adhesive matrix further comprises colloidal silicone dioxide or fumed silica. 12. The method of claim 1, wherein tamsulosin is a salt of tamsulosin and the matrix further comprises a neutralizing agent. 13. The method of claim 12, wherein tamsulosin is tamsulosin hydrochloride. 14. The method of claim 1, wherein the alpha-hydroxy acid is selected from the group consisting of lactic acid and glycolic acid. 15. A method for treating benign prostatic hyperplasia, comprising: providing a transdermal patch comprising an adhesive matrix comprised of polyisobutylene, a solvent selected from dimethylacetamide, n-methylpyrrolidone and dimethylsulfoxide, a mixture of an unsaturated fatty acid and an alpha-hydroxy acid, a permeation enhancer of the formula CH3(CH2)mOCOCHR1R2, where m is an integer in the range of 6 to 14, R1 and R2 are each independently selected from hydrogen, hydroxyl, and a C1-C2 lower alkyl group, wherein at least one of R1 and R2 is hydroxyl or both R1 and R2 are hydrogen, and tamsulosin; andadministering or instructing to administer the transdermal patch. 16. The method of claim 15, wherein the solvent is dimethylsulfoxide. 17. The method of claim 15, wherein tamsulosin is tamsulosin base. 18. The method of claim 15, wherein the permeation enhancer is lauryl lactate. 19. The method of claim 15, wherein the unsaturated fatty acid is oleic acid.
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Schiraldi Michael T. (East Brunswick NJ) Perl Martin M. (Brooklyn NY) Rubin Howard (Rockaway NJ), Bioadhesive extruded film for intra-oral drug delivery and process.
Anderson John McCune (16 Torgrange Holywood ; County Down ; BT18 ONG ; Northern Ireland GBX) McAdams Eric Thomas (Ormsdale ; 52 Cable Road Whitehead ; County Antrim ; Northern Ireland BT38 9 PZ GBX) , Biomedical electrode device.
Arraudeau Jean-Pierre (Paris FRX) Patraud Jeanne (Paris FRX) Le Gall Louis (Bures-sur-Yvette FRX), Composition based on cationic polymers, anionic polymers and waxes for use in cosmetics.
Kulichikhin,Valery G.; Parandoosh,Shoreh; Feldstein,Mikhail M.; Antonov,Sergey; Cleary,Gary W., Composition for cushions, wound dressings and other skin-contacting products.
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Takoh Noboru,JPX ; Kondo Masahiro,JPX ; Inoue Hiroshi,JPX, Composition used for hydrophilization and method for hydrophilization using said composition.
Kanios David P. ; Gentile Joseph A. ; Mantelle Juan A. ; Sablotsky Steven, Compositions and methods for topical administration of pharmaceutically active agents.
Bloom Roberta C. (Huntington CT) Deckner George E. (Cincinnati OH), Compositions for topical delivery of drugs comprising a mixture of high and low HLB surfactants and alkoxylated ether.
Magnus, Philip D.; Payne, Andrew H., Conversion of α,β-unsaturated ketones and α,β-unsaturated esters into α-hydroxy ketones and α-hydroxy esters using Mn(III) catalyst, phenylsilane and dioxygen.
Lee Eun Soo (Redwood City CA) Theeuwes Felix (Los Altos Hills CA) Wong S. L. Patrick (Hayward CA) Yum Su Il (Los Altos CA) Zaffaroni Alejandro (Atherton CA), Delayed onset transdermal delivery device.
Sagel Paul A. ; Dirksing Robert S. ; Rohman Frederick J., Delivery system for a tooth whitener using a strip of material having low flexural stiffness.
Sagel Paul Albert ; Dirksing Robert Stanley ; Rohman Frederick James, Delivery system for a tooth whitener using a strip of material having low flexural stiffness.
Dirksing Robert S. ; Sagel Paul A. ; Tweddell ; III Richard, Delivery system for an oral care substance using a permanently deformable strip of material.
Sagel Paul A. ; Dirksing Robert S. ; Rohman Frederick J., Delivery system for an oral care substance using a strip of material having low flexural stiffness.
Sagel Paul Albert ; Dirksing Robert Stanley ; Rohman Frederick James ; Majeti Satyanarayana ; Reno Elizabeth Ann, Delivery system for an oral care substance using a strip of material having low flexural stiffness.
Curtis John (Bloomsbury NJ) Nahoo Salim (Piscataway NJ) Prencipe Michael (E. Windsor NJ), Dental material and method for applying preventative and therapeutic agents.
Chang Yunik (Toms River NJ) Patel Dinesh C. (Murray UT) Ebert Charles D. (Salt Lake City UT), Device for administering an active agent to the skin or mucosa.
Chang Yunik (Toms River NJ) Patel Dinesh C. (Murray UT) Ebert Charles D. (Salt Lake City UT), Device for administering an active agent to the skin or mucosa.
Chheang, Theary; Hine, Andrew M.; Muggli, Mark W.; Noe, Susan C.; Sanft, Patricia M.; Schultz, William J.; Taylor, Robert D.; Tead, Stanley F., Devices, compositions, and methods incorporating adhesives whose performance is enhanced by organophilic clay constituents.
Gyory J. Richard (Los Altos CA) Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Lew Patrick J. (Mountain View CA), Electrotransport adhesive.
Tseng Susan Y. (Staten Island NY) Wolf Philip F. (Bridgewater NJ) Burlant William J. (Wayne NJ), Films and extrusions of cured crosslinked vinyl lactam polymer and method of preparation.
Roreger Michael (Neuwied DEX) Herrmann Fritz (Neuwied DEX) Hoffmann Hans-Rainer (Neuwied DEX) List Harald (Neuwied DEX), Flexible, hydrophilic gel film, the process for its production and the use of it.
Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions demonstrating phase separation on contact with aqueous media.
Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions demonstrating phase separation on contact with aqueous media.
Singh, Parminder; Faasse, Adrian; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions with an erodible backing member.
Murray Douglas G. (Willowdale CAX) Smith Dennis C. (Toronto CAX) Guillet James E. (Don Mills CAX), Hydrogel-forming wound dressing or skin coating material.
Holmblad Carolann M. (Cambridge MN) Bergstrom Joan M. (Minneapolis MN) Bartlett Terese A. (Circle Pines MN), Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs.
Jevne Allan H. (Anoka MN) Vegoe Brett R. (Brooklyn Park MN) Holmblad Carolann M. (Cambridge MN) Cahalan Patrick T. (Champlin MN), Hydrophilic pressure sensitive biomedical adhesive composition.
Nielsen Kent E.,CAX ; Li Kai,CAX ; Kantner Steven S. ; Koski Nancy L. ; Everaerts Albert I., Ionically conductive adhesives prepared from zwitterionic materials and medical devices using such adhesives.
Gyory J. Richard (Los Altos CA) Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Lew Patrick J. (Mountain View CA), Iontophoretic device incorporating an electrotransport adhesive.
Samour Carlos ; Krauser Scott F., Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery.
Broberg Berndt F. J. (Sdertlje SEX) Evers Hans C. A. (Sdertlje SEX), Local anesthetic mixture for topical application and method for obtaining local anesthesia.
Broberg, Berndt F. J.; Evers, Hans C. A., Local anesthetic mixture for topical application, process for its preparation, as well as method for obtaining local anesthesia.
Itoh Steven K. (Cottage Grove MN) Dietz Timothy M. (St. Paul MN) Uy Rosa (St. Paul MN), Low impedance pressure sensitive adhesive composition and biomedical electrodes using same.
Yeo, Woon-Sung; Yun, Yeo-Han, Method for forming an information recording medium having information on spare area, and method and apparatus for recording/reproducing data to/from the medium.
Barton James Bradbury ; Shari Joy Soper ; Joseph Robert Kaczvinsky, Jr. ; Dorothy Limerick Bailey ; Celeste Dawn Gale, Method for regulating hair growth.
Gleich Gerald J. (Rochester MN) Ohnishi Tsukasa (Tokyo JPX) Hunt Loren W. (Rochester MN), Method for the treatment of eosinophil-associated diseases by administration of topical anesthetics.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of Selectively applying needle array configurations.
Feldstein, Mikhail M.; Bairamov, Danir F.; Platé, Nicolai A.; Kulichikhin, Valery G.; Chalykh, Anatoly E.; Cleary, Gary W.; Singh, Parminder, Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components.
Moro, Daniel G.; Callahan, Howard; Nowotnik, David, Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds.
Tucker Mark J. (Round Steps ; High Street Stow-on-the-Wold ; Gloucester GL54 1DL GBX) Tucker Mark R. (P.O. Box 23530 Bahrain BHX), Occlusive body for administering a physiologically active substance.
Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
Lerner E. Itzhak,ILX ; Rosenberger Vered,ILX ; Flashner Moshe,ILX, Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity.
Dietz Timothy M. (St. Paul MN) Lu Ying-Yuh (Woodbury MN) Uy Rosa (St. Paul MN) Young Chung I. (Roseville MN), Polymerized microemulsion pressure sensitive adhesive compositions and methods of preparing and using same.
Feldstein, Mikhail M.; Plate, Nicolai A.; Chalykh, Anatoly E.; Cleary, Gary W., Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties.
Therriault Donald J. (Lowell MA) Temin Samuel C. (Needham MA) Shah Kishore R. (Bridgewater NJ), Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery.
Duan Daniel C. (St. Paul MN) Asmus Robert A. (Township of Hudson ; County of St. Croix WI) Dietz Timothy M. (St. Paul MN) Uy Rosa (St. Paul MN) Benson ; Jr. Olester (Woodbury MN), Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same.
Plate Nicolai A.,RUX ; Valuev Lev I.,RUX ; Uzhinova Lubov D.,RUX ; Sinani Vladimir A.,RUX, Process for preparing biologically compatible polymers and their use in medical devices.
Singh, Parminder; Mudumba, Sri; Bairamov, Danir R.; Kulichikhin, Valery G.; Feldstein, Mikhail M.; Cleary, Gary W., Rapidly dissolving film for delivery of an active agent.
Singh, Parminder; Mudumba, Sri; Bayramov, Danir F.; Kulichikhin, Valery G.; Feldstein, Mikhail M.; Cleary, Gary W., Rapidly dissolving film for delivery of an active agent.
Pfister William R. (Bay City MI) Wilson Jeniffer M. (Saginaw MI), Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices.
Lee Eun Soo (Redwood City CA) Nedberge Diane E. (Los Altos CA) Yum Su Il (Los Altos CA), Skin permeation enhancer compositions using glycerol monolinoleate.
Chiang Chia-Ming (Foster City CA) Cleary Gary W. (San Mateo CA), Skin permeation enhancer compositions, and methods and transdermal systems associated therewith.
Miranda Jesus (Miami FL) Sablotsky Steven (Miami FL), Solubility parameter based drug delivery system and method for altering drug saturation concentration.
Wagner Julie Ann ; Zukowski Joseph Michael ; Robinson Larry Richard ; Deckner George Endel ; Rinaldi Marie Antoinette ; Szymanski Victoria Claire, Stable topical compositions.
Jones, Todd K.; Goldman, Mark E.; Pooley, Charlotte L. F.; Winn, David T.; Edwards, James P.; West, Sarah J.; Tegley, Christopher M.; Zhi, Lin; Hamann, Lawrence G.; Farmer, Luc J.; Davis, Robert L., Steroid receptor modulator compounds and methods.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Turner Josephine S. (Kettleby CAX) Murray D. Gary (Willowdale CAX) Zuccolin John D. (Stouffville CAX) Li Ruey S. (Thornhill CAX), Substance transfer system for topical application.
Gale Robert M. (Los Altos CA) Nedberge Diane E. (Los Altos CA) Atkinson Linda E. (Portola Valley CA), Transdermal contraceptive formulations, methods and devices.
Min Dong Son,KRX ; Um Kee An,KRX ; Kim Yong Soo,KRX ; Park Pyeong Uk,KRX ; Kim Key Hyup,KRX ; Yang Ho Seung,KRX ; Jeong Hey Soon,KRX ; Park Mi Young,KRX, Transdermal delivery matrix for piroxicam.
Ebert Charles D. (Salt Lake City UT) Heiber Werner (Salt Lake City UT) Good William R. (Salt Lake City UT) Venkateshwaran Srinivasan (Salt Lake City UT), Transdermal delivery system with adhesive overlay and peel seal disc.
Chiang Chia-Ming (Foster City CA) Colley Kenneth J. (Washington DC) Cleary Gary W. (San Mateo CA), Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset.
Ma Xinghang ; Audett Jay ; Soni Pravin L. ; Singh Noel ; Bailey Susan E., Transdermal drug delivery sytem for the administration of tamsulosin, and related compositions and methods of use.
Chien Yie W. (North Brunswick NJ) Chien Te-Yen (Piscataway NJ) Huang Yih-Chain (Piscataway NJ), Transdermal estrogen/progestin dosage unit, system and process.
Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
Horstmann Michael (Neuwied DEX) Herrmann Fritz (Neuwied DEX), Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof.
Kleinsorgen Reinhard v.,DEX ; Kleinsorgen Britta v.,DEX, Transdermal therapeutic system with small application-area thickness and great flexibility, and production process.
Jan A. Orlowski ; David V. Butler, Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals.
Dietz Timothy M. (St. Paul MN) Asmus Robert A. (Hudson WI) Uy Rosa (St. Paul MN), Two-phase composites of ionically-conductive pressure-sensitive adhesive, biomedical electrodes using the composites, an.
Login Robert B. (Oakland NJ) Merianos John J. (Middletown NJ) Biss Russell B. (Paramus NJ) Garelick Paul (South Plainfield NJ), Urea-hydrogen peroxide-polyvinylpyrrolidone.
Login Robert B. (Oakland NJ) Merianos John J. (Middletown NJ) Biss Russell B. (Wayne NJ) Garelick Paul (South Plainfield NJ), Urea-hydrogen peroxide-polyvinylpyrrolidone process.
Kantner Steven S. ; Kuester Wilhelm,DEX, Use of pendant free-radically polymerizable moieties with polar polymers to prepare hydrophilic pressure sensitive adhes.
Gaglio Thomas J. (4421 La Paloma Santa Barbara CA 93105) Santoriello Luigi (3463 State St. ; #359 Santa Barbara CA 93105), Viscous fluid dispensing apparatus.
Kim Son Nguyen,DEX ; Sanner Axel,DEX ; Hossel Peter,DEX ; Schehlmann Volker,DEX, Water-soluble or water-dispersible graft copolymers based on a polyvinyllactam, their preparation and use.
Biegajski James E. (Foster City CA) Venkatraman Subbu S. (Palo Alto CA) Scott Ann M. (Mountain View CA), Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavi.
Beier Helmut (Darmstadt DEX) Petereit Hans-Ulrich (Darmstadt DEX) Bergmann Gunter (Hanau DEX), Water-soluble pressure-sensitive skin adhesive, its use, and agents provided with it.
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