Fiber scaffolds for use in tracheal prostheses
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B29C-067/00
A61F-002/20
A61L-027/36
A61L-027/38
A61L-027/40
A61F-002/04
B29C-064/00
B29K-067/00
B29K-075/00
B29K-311/00
출원번호
US-0677644
(2012-11-15)
등록번호
US-10239262
(2019-03-26)
발명자
/ 주소
Johnson, Jed K.
출원인 / 주소
NANOFIBER SOLUTIONS, LLC
대리인 / 주소
Pepper Hamilton LLP
인용정보
피인용 횟수 :
0인용 특허 :
13
초록▼
A synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one
A synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one layer of polymer fibers that have been deposited by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both; and wherein the polymer scaffold has been preseeded with at least one type of biological cell prior to implantation into a biological organism, and wherein the at least one type of biological cell is operative to facilitate integration of the polymer scaffold into the organism so that the polymer scaffold may function in a manner significantly similar to or the same as the native organ.
대표청구항▼
1. A synthetic organ comprising: a scaffold comprising at least one polymeric electrospun fiber and a plurality of porous synthetic cartilage rings, the scaffold having a shape based on a native human trachea; andat least one type of biological cell selected from the group consisting of autologous c
1. A synthetic organ comprising: a scaffold comprising at least one polymeric electrospun fiber and a plurality of porous synthetic cartilage rings, the scaffold having a shape based on a native human trachea; andat least one type of biological cell selected from the group consisting of autologous cells, allogeneic cells, cord blood cells, embryonic stem cells, induced pluripotent cells, mesenchymal cells, placental cells, bone marrow derived cells, hematopoietic cells, epithelial cells, endothelial cells, fibroblasts and chondrocytes;wherein the porous synthetic cartilage rings consist of polyurethane; andwherein the porous synthetic cartilage rings have a pore diameter of about 10 μm to about 30 μm. 2. The synthetic organ of claim 1, further comprising a compound selected from the group consisting of proteins, peptides, and combinations thereof. 3. The synthetic organ of claim 1, further comprising a selectively dissolvable particle. 4. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber comprises a non-resorbable material selected from the group consisting of polyethylene terephthalate, silicone, polyurethane, polycarbonate, polyether ketone, and combinations thereof. 5. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber comprises a resorbable material selected from the group consisting of polycaprolactone (PCL), polylactic acid (PLA), polyglycolic acid (PGA), and combinations thereof. 6. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber comprises a predetermined ratio of one or more polymers selected from the group consisting of polyethylene terephthalate (PET), polyetherketoneketone (PEKK), polyurethane (PU), polycarbonate (PC), polyamide (Nylon), and combinations thereof. 7. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber comprises a natural polymer selected from the group consisting of collagen, gelatin, fibronectin, hyaluronic acid, and combinations thereof. 8. The synthetic organ of claim 1, further comprising an additive selected from the group consisting of fluorescence compounds, radio opaque compounds, anti-bacterial compounds, growth hormones, conductive compounds, ceramic compounds, metallic compounds, oxygen sensing compounds, radioactive compounds, cell growth promoting compounds, proteins, hormones, cytokines, and combinations thereof. 9. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber has a diameter of about 250 nm and a pore size of about 3-5 μm. 10. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber further comprises pores, dimples, hairs, or combinations thereof. 11. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber comprises a blend of polyethylene terephthalate and polyurethane. 12. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber comprises polyethylene terephthalate fibers and polyurethane fibers. 13. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber has a diameter of about 1 μm and a pore size of about 7-10 μm. 14. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber has a diameter of about 10 μm and a pore size of about 50-70 μm. 15. The synthetic organ of claim 1, wherein the at least one polymeric electrospun fiber comprises 50 wt % polyethylene terephthalate and 50 wt % polyurethane.
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이 특허에 인용된 특허 (13)
Chu,Benjamin; Hsiao,Benjamin S.; Fang,Dufei; Brathwaite,Collin, Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications.
Scott-Carnell, Lisa A.; Stephens, Ralph M; Holloway, Nancy M.; Rhim, Caroline; Niklason, Laura; Clark, Robert L.; Siochi, Emilie J., Method and system for aligning fibers during electrospinning.
Arnal, Kevin R.; Hauschild, Sidney F.; Lund, Robert E.; Roychowdhury, Suranjan; Vancelette, David W., Surgical implants and related methods and systems.
Ying, Jackie Y.; Kan, Shyi-Herng; Hock, Jeremy Loh Ming; Schumacher, Karl; Hsieh, James Tseng-Ming, Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement.
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