The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or
The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
대표청구항▼
1. A method for spray-drying plasma, the method comprising: providing plasma having a protein concentration and derived from human blood to a spray-drying apparatus;spray-drying, at the spray-drying apparatus, the plasma to form physiologically-active plasma powder, the spray-drying apparatus config
1. A method for spray-drying plasma, the method comprising: providing plasma having a protein concentration and derived from human blood to a spray-drying apparatus;spray-drying, at the spray-drying apparatus, the plasma to form physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma, wherein the one or more parameters comprise an inlet temperature of substantially between 100° to 114° C., a pump setting of substantially between 18 to 28%, an aspiration setting of substantially between 80% to 100%, a spray flow rate of substantially between 30 to 40 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof;storing the physiologically-active plasma powder for a storage time; andreconstituting the physiologically-active plasma powder utilizing a reconstitution fluid to form physiologically-active reconstituted plasma. 2. The method of claim 1, wherein the one or more parameters comprise an inlet temperature of substantially 107° C., a pump setting of substantially 24%, an aspiration setting of substantially 100%, a spray flow rate of substantially 35 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof. 3. The method of claim 2, wherein the spray flow rate is nitrogen flow rate. 4. The method of claim 1, further comprising applying the physiologically-active reconstituted plasma to a human. 5. The method of claim 1, wherein a recovery rate of proteins of the physiologically-active reconstituted plasma is at least 90%. 6. The method of claim 1, wherein the reconstitution fluid comprises distilled water, glycine, or any combination thereof. 7. The method of claim 1, further comprising: determining a spray-drying apparatus outlet temperature of the physiologically-active plasma powder; andadjusting a spray-drying apparatus pump setting and/or a spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature. 8. The method of claim 7, wherein the adjusting of the spray-drying apparatus pump setting and/or the spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature further comprises adjusting the spray-drying apparatus pump setting and/or the spray-drying inlet temperature if the spray-drying apparatus outlet temperature is not between substantially 40° to 44° C. 9. A spray-dried physiologically-active plasma prepared by: providing plasma having a protein concentration derived from blood to a spray-drying apparatus;spray-drying, at the spray-drying apparatus, the plasma to form a physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma, wherein the one or more parameters comprise an inlet temperature of substantially between 100° to 114° C., a pump setting of substantially between 18 to 28%, an aspiration setting of substantially between 80% to 100%, a spray flow rate of substantially between 30 to 40 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof; andreconstituting the physiologically-active plasma powder utilizing a reconstitution fluid to form physiologically-active reconstituted plasma. 10. The spray-dried physiologically-active plasma of claim 9, wherein the one or more parameters comprise an inlet temperature of substantially 107° C., a pump setting of substantially 24%, an aspiration setting of substantially 100%, a spray flow rate of substantially 35 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof. 11. The spray-dried physiologically-active plasma of claim 10, wherein the spray flow rate is nitrogen flow rate. 12. A method for spray-drying plasma, the method comprising: providing plasma having a protein concentration and derived from human blood to a spray-drying apparatus;spray-drying, at the spray-drying apparatus, the plasma to form physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma;determining a spray-drying apparatus outlet temperature of the physiologically-active plasma powder;adjusting a spray-drying apparatus pump setting and/or a spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature, wherein the adjusting of the spray-drying apparatus pump setting and/or the spray-drying apparatus inlet temperature based on the spray-drying apparatus outlet temperature further comprises adjusting the spray-drying apparatus pump setting and/or the spray-drying inlet temperature if the spray-drying apparatus outlet temperature is not between substantially 40° to 44° C.storing the physiologically-active plasma powder for a storage time; andreconstituting the physiologically-active plasma powder utilizing a reconstitution fluid to form physiologically-active reconstituted plasma. 13. A method for spray-drying plasma, the method comprising: providing plasma having a protein concentration and derived from human blood to a spray-drying apparatus;spray-drying, at the spray-drying apparatus, the plasma to form physiologically-active plasma powder, the spray-drying apparatus configured utilizing one or more parameters dependent on the protein concentration of the plasma, wherein the one or more parameters comprise an inlet temperature of substantially between 100° to 114° C., a pump setting of substantially between 18 to 28%, an aspiration setting of substantially between 80% to 100%, a spray flow rate of substantially between 30 to 40 mm Hg, an outlet temperature of substantially between 40° to 44° C., or any combination thereof;storing the physiologically-active plasma powder for a storage time; andapplying the physiologically-active plasma powder directly to a human via application of the physiologically-active plasma powder directly to a wound on the human.
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