최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0968391 (2015-12-14) |
등록번호 | US-10258406 (2019-04-16) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 1506 |
A computer-implemented system for delivering energy to tissue having a necrotic threshold may generally comprise an electrode array comprising a plurality of electrodes, a central electrode positioned intermediate the plurality of electrodes, and a controller configured to not only apply a first seq
A computer-implemented system for delivering energy to tissue having a necrotic threshold may generally comprise an electrode array comprising a plurality of electrodes, a central electrode positioned intermediate the plurality of electrodes, and a controller configured to not only apply a first sequence of electrical pulses to the electrode array to induce thermal heating in the tissue and reduce the necrotic threshold of the tissue but also apply a second sequence of electrical pulses to the central electrode to induce cell necrosis in the tissue by irreversible electroporation. Electrical ablation devices and methods of using the same are also described herein.
1. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the computer-implemented system comprising: an electrode array comprising a plurality of electrodes;a central electrode positioned intermediate the plurality of electrodes;a ground pad adjacent the tissue;a
1. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the computer-implemented system comprising: an electrode array comprising a plurality of electrodes;a central electrode positioned intermediate the plurality of electrodes;a ground pad adjacent the tissue;a processor; anda memory coupled to the processor and storing instructions to be executed by the processor to: apply a first sequence of electrical pulses to the electrode array less than the necrotic threshold to induce thermal heating in the tissue;apply a second sequence of electrical pulses to the central electrode equal to or greater than the necrotic threshold to induce cell necrosis in the tissue by irreversible electroporation; andapply a ground potential to the ground pad. 2. The computer-implemented system of claim 1, further comprising an energy source coupled to the electrode array and the central electrode, wherein the energy source is operative to generate and deliver the first sequence of electrical pulses and the second sequence of electrical pulses to the tissue. 3. The computer-implemented system of claim 2, further comprising at least one of a temperature sensor and a pressure sensor adjacent at least one of the electrode array and the central electrode, wherein the energy source is operative to generate and deliver the second sequence of electrical pulses when at least one of a predetermined temperature and a predetermined pressure is achieved. 4. The computer-implemented system of claim 2, further comprising a controller comprising the processor and the memory, wherein the controller is coupled to the energy source, and wherein the controller is configured to control at least one parameter associated with the delivery of the first sequence of electrical pulses and the second sequence of electrical pulses. 5. The computer-implemented system of claim 4, wherein the at least one parameter comprises frequency, amplitude, pulse width, polarity, voltage, total number of pulses, and delay between pulses bursts. 6. The computer-implemented system of claim 1, wherein the first sequence of electrical pulses is sufficient to create a thermal zone in a first portion of the tissue induced by thermal heating in an area near an electrode-tissue-interface of each of the plurality of electrodes, and wherein the second sequence of electrical pulses is sufficient to create a necrotic zone in a second portion of tissue induced by irreversible electroporation in an area surrounding each of the plurality of electrodes and the central electrode. 7. The computer-implemented system of claim 1, further comprising instructions to be executed by the processor to: deliver a first energy dose that is less than the necrotic threshold to induce thermal heating by the first sequence of electrical pulses; anddeliver a second energy dose equal to or greater than the necrotic threshold to induce cell necrosis in the tissue by irreversible electroporation by the second sequence of electrical pulses. 8. The computer-implemented system of claim 1, further comprising instructions to be executed by the processor to: form a pre-heated zone by applying an electric field that is less than about 800 V/cm by the first sequence of electrical pulses; andform a necrotic zone by applying an electric filed that is greater than about 800 V/cm by the second sequence of electrical pulses. 9. The computer-implemented system of claim 1, further comprising instructions to be executed by the processor to: heat the mass of tissue by applying an electric field that is less than about 800V/cm by the first sequence of electrical pulses to lower the necrotic threshold; andinduce cell necrosis by irreversible electroporation by applying an electric filed that is greater than about 800 V/cm by the second sequence of electrical pulses. 10. The computer-implemented system of claim 1, further comprising instructions to be executed by the processor to: apply the first sequence of electrical pulses to the electrode array less than the necrotic threshold to lower the necrotic threshold. 11. The computer-implemented system of claim 1, further comprising instructions to be executed by the processor to: apply a sequence of electrical pulses to the electrode array, the sequence of electrical pulses having amplitudes in a range of about ±100 VDC to about ±10,000 VDC, pulse widths in a range of about 1 μs to about 100 ms, and frequencies in a range of about 1 Hz to about 10,000 Hz; andre-apply the sequence of electrical pulses to the central electrode. 12. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the system comprising: an electrode arrangement comprising a plurality of outer electrodes;an inner electrode surrounded by the plurality of outer electrodes;a processor; anda memory coupled to the processor and storing instructions to be executed by the processor to: apply a first sequence of electrical pulses to the plurality of outer electrodes to induce thermal heating in the tissue without inducing irreversible electroporation in the tissue; andapply a second sequence of electrical pulses to the inner electrode to induce cell necrosis in the tissue by irreversible electroporation. 13. The computer-implemented system of claim 12, further comprising a ground pad adjacent the tissue and instructions to be executed by the processor to apply a ground potential to the ground pad. 14. The computer-implemented system of claim 12, wherein the first sequence of electrical pulses comprises a first energy dose that is less than the necrotic threshold, and wherein the second sequence of electrical pulses comprises a second energy dose that is equal to or greater than the necrotic threshold. 15. The computer-implemented system of claim 12, further comprising an energy source electrically coupled to the plurality of outer electrodes and the inner electrode. 16. The computer-implemented system of claim 15, further comprising at least one of a temperature sensor for measuring temperature in the tissue and a pressure sensor for measuring pressure in the tissue. 17. The computer-implemented system of claim 16, wherein the energy source is operative to: generate and deliver the first sequence of electrical pulses until at least one of a predetermined temperature and a predetermined pressure is achieved; andgenerate and deliver the second sequence of electrical pulses when the at least one of a predetermined temperature and a predetermined pressure is achieved. 18. A computer-implemented system for delivering energy to tissue having a necrotic threshold, the system comprising: an electrode array comprising a plurality of electrodes;a central electrode positioned intermediate the plurality of electrodes; anda controller configured to: apply a first sequence of electrical pulses to the electrode array to induce thermal heating in the tissue and reduce the necrotic threshold of the tissue; andapply a second sequence of electrical pulses to the central electrode to induce cell necrosis in the tissue by irreversible electroporation. 19. The computer-implemented system of claim 18, wherein the plurality of electrodes and the central electrode are configured for insertion into the tissue. 20. The computer-implemented system of claim 18, wherein the controller is configured to apply the first sequence of electrical pulses to thermally heat the tissue to a predetermined threshold to realize a reduced necrotic threshold of the tissue.
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