Methods for treating cancer in patients with elevated levels of BIM
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07K-016/28
G01N-033/574
C12Q-001/6886
A61K-039/00
출원번호
US-0026461
(2014-09-03)
등록번호
US-10259875
(2019-04-16)
국제출원번호
PCT/US2014/053870
(2014-09-03)
국제공개번호
WO2015/050663
(2015-04-09)
발명자
/ 주소
Dong, Haidong
Harrington, Susan M.
Kwon, Eugene D.
Krco, Christopher J.
Liu, Xin
출원인 / 주소
Mayo Foundation for Medical Education and Research
대리인 / 주소
Fish & Richardson P.C.
인용정보
피인용 횟수 :
0인용 특허 :
115
초록▼
Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, an
Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.
대표청구항▼
1. A method for identifying a mammal having cancer as being likely to benefit from checkpoint blockade therapy and treating said mammal, wherein said method comprises: (a) identifying a mammal as containing an elevated level of Bim and having a tumor that expresses B7-H1, and(b) administering to sai
1. A method for identifying a mammal having cancer as being likely to benefit from checkpoint blockade therapy and treating said mammal, wherein said method comprises: (a) identifying a mammal as containing an elevated level of Bim and having a tumor that expresses B7-H1, and(b) administering to said mammal an anti-PD-1 antibody under conditions wherein the interaction of naturally-occurring B7-H1 with PD-1 in said mammal is reduced after said administering. 2. The method of claim 1, wherein said mammal is a human. 3. The method of claim 1, wherein said elevated level of Bim is based on Bim protein levels. 4. The method of claim 1, wherein said elevated level of Bim is based on the level of mRNA encoding Bim. 5. The method of claim 1, wherein said cancer is a melanoma cancer, a breast cancer, a lung cancer, a renal cell carcinoma cancer, a pancreas cancer, a prostate cancer, a colon cancer, a brain cancer, a liver cancer, or an ovarian cancer. 6. A method for treating a mammal having cancer, wherein said method comprises administering an anti-PD-1 antibody to a mammal identified as containing an elevated level of Bim and having a tumor that expresses B7-H1, and thus identified as being likely to benefit from checkpoint blockade therapy, wherein said administering is under conditions wherein interaction of naturally-occurring B7-H1 with PD-1 in said mammal is reduced. 7. The method of claim 6, wherein said mammal is a human. 8. The method of claim 6, wherein said elevated level of Bim is based on Bim protein levels. 9. The method of claim 6, wherein said elevated level of Bim is based on the level of mRNA encoding Bim. 10. The method of claim 6, wherein said cancer is a melanoma cancer, a breast cancer, a lung cancer, a renal cell carcinoma cancer, a pancreas cancer, a prostate cancer, a colon cancer, a brain cancer, a liver cancer, or an ovarian cancer.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (115)
Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR) Stirchak Eugene P. (Corvallis OR), Alpha-morpholino ribonucleoside derivatives and polymers thereof.
Waldmann Herman (University of Cambridge ; Department of Pathology ; Immunology Div. ; Tennis Court Road Cambridge ; CB2 1QP GB3) Walsh Louise (The University of Cambridge ; Department of Pathology ;, CDR grafted humanised chimeric T-cell antibodies.
Dalie Barbara ; Le Hung V. ; Miller Kenneth ; Murgolo Nicholas J. ; Nguyen Hanh ; Tindall Stephen ; Zavodny Paul J., Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4.
Chen,Lieping; Strome,Scott E., Detection of antibodies specific for B7-H1 in subjects with diseases or pathological conditions mediated by activated T cells.
Bendig Mary M. (London GBX) Kettleborough Catherine A. (Herts GBX) Saldanha Jose (Middlesex GBX), Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies.
Queen Cary L. (Los Altos CA) Co Man Sung (Cupertino CA) Schneider William P. (Mountain View CA) Landolfi Nicholas F. (Milpitas CA) Coelingh Kathleen L. (San Francisco CA) Selick Harold E. (Belmont CA, Humanized immunoglobulins.
Woodle Martin C. (Menlo Park CA) Martin Francis J. (San Francisco CA) Yau-Young Annie (Los Altos CA) Redemann Carl T. (Walnut Creek CA), Liposomes with enhanced circulation time.
Honjo, Tasuku; Minato, Nagahiro; Iwai, Yoshiko; Shibayama, Shiro, Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1.
Sledziewski Andrzej Z. (Seattle WA) Bell Lillian A. (Seattle WA) Kindsvogel Wayne R. (Seattle WA), Method of producing secreted receptor analogs and biologically active peptide dimers.
Aruffo Alejandro A. ; Chalupny N. Jan ; Chen Lieping ; Mittler Robert S. ; Shuford Walter W. ; Siadak Anthony W., Methods and compositions for immunomodulation.
Johnson Kevin Stuart,GBX ; Winter Gregory Paul,GBX ; Griffiths Andrew David,GBX ; Smith Andrew John Hammond,GBX ; Waterhouse Peter Michael,AUX, Methods for producing members of specific binding pairs.
Freeman, Gordon J.; Chernova, Irene; Chernova, Tatyana; Malenkovich, Nelly; Wood, Clive R., Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1.
Freeman,Gordon; Chernova,Irene; Chernova,Tatyana; Malenkovich,Nelly; Wood,Clive; Latchman,Yvette; Sharpe,Arlene H., Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal.
Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions.
Sledziewski Andrzej Z. ; Bell Lillian Anne ; Kindsvogel Wayne R., Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions.
Sledziewski Andrzej Z. (Seattle WA) Bell Lillian A. (Seattle WA) Kindsvogel Wayne R. (Seattle WA), Methods of using biologically active dimerized polypeptide fusions to detect PDGF.
Matteucci Mark (Burlingame CA) Jones Robert J. (Daly City CA) Munger John (San Francisco CA), Modified internucleoside linkages having one nitrogen and two carbon atoms.
Robinson Randy R. (Los Angeles CA) Liu Alvin Y. (Oceanside CA) Horwitz Arnold H. (Los Angeles CA) Better Marc (Los Angeles CA) Wall Randolph (Sherman Oaks CA) Lei Shau-Ping (Los Angeles CA) Wilcox Ga, Modular assembly of antibody genes, antibodies prepared thereby and use.
Robinson Randy R. (Los Angeles CA) Liu Alvin Y. (Oceanside CA) Horwitz Arnold H. (Los Angeles CA) Better Marc (Los Angeles CA) Wall Randolph (Sherman Oaks CA) Lei Shau-Ping (Los Angeles CA) Wilcox Ga, Modular assembly of antibody genes, antibodies prepared thereby and use.
Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
Queen Cary L. (Los Altos CA) Schneider William P. (Mountain View CA) Selick Harold E. (Belmont CA), Polynucleotides encoding improved humanized immunoglobulins.
Okamoto Tadashi,JPX ; Yamamoto Nobuko,JPX, Process for detecting target nucleic acid, process for quantifying the same, and pyrylium compound for chemiluminescence analysis.
Hoogenboom Hendricus R. J. M. (Cambridge GBX) Baier Michael (Frankfurt DEX) Jespers Laurent S. A. T. (Tervuren BEX) Winter Gregory P. (Cambridge GBX), Production of chimeric antibodies - a combinatorial approach.
Platz Robert M. (Half Moon Bay CA) Winters Mark A. (Mountain View CA) Pitt Colin G. (Thousand Oaks CA), Pulmonary administration of granulocyte colony stimulating factor.
Cech Thomas R. (Boulder CO) Zaug Arthur J. (Louisville CO) Been Michael D. (Boulder CO), RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods.
Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
Pedersen Jan T. (Bath GBX) Searle Stephen M. J. (Bath GBX) Rees Anthony R. (Bath GBX) Roguska Michael A. (Ashland MA) Guild Braydon C. (Concord MA), Resurfacing of rodent antibodies.
Goldenberg Milton D. (11837 Gainsborough Rd. Potomac MD 20854), Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.