한국 근해와 열대 태평양, 남극 연안 등 다양한 해양환경에 서식하는 160여 종, 800 kg의 저서군체 동물(해면, 산호, 원색동물 등)을 체계적으로 채집, 분류하고 세포독성, 항산화, 효소활성저해, 항바이러스 활성 등의 생리활성검색에 의하여 41종의 유용시료를 파악. 다양한 해양동식물과 해저 퇴적물로부터 3,100 종의 방선균과 해양세균을 분리, 순수배양, 보존하고 78종의 고역가 세포독성 및 항진균 활성균주를 파악. 생리활성과 화학적 분석에 의거하여 선정된 동물 및 미생물 시료로부터 크로마토그래피를 이용하여 신물질 53 종을
한국 근해와 열대 태평양, 남극 연안 등 다양한 해양환경에 서식하는 160여 종, 800 kg의 저서군체 동물(해면, 산호, 원색동물 등)을 체계적으로 채집, 분류하고 세포독성, 항산화, 효소활성저해, 항바이러스 활성 등의 생리활성검색에 의하여 41종의 유용시료를 파악. 다양한 해양동식물과 해저 퇴적물로부터 3,100 종의 방선균과 해양세균을 분리, 순수배양, 보존하고 78종의 고역가 세포독성 및 항진균 활성균주를 파악. 생리활성과 화학적 분석에 의거하여 선정된 동물 및 미생물 시료로부터 크로마토그래피를 이용하여 신물질 53 종을 포함하는 60여종의 천연물 분리정제 완료. 분광학과 유기반응에 의하여 천연물? 구조를 규명하고 생리활성을 검색. 이들 중에서 국내 자생 해면동물에서 유래한 신규의 무독성 혈관신생억제물질인 원도닌(wondonins)를 일차적인 의약활성 후보물질로 선정하여 이 천연물의 효과적인 대량분이 방법을 개발. 아울러 고역가 항암성 펩타이드를 대상으로 유기반응에 의하여 10 여종의 신규 유도체를 합성하고 생리활성돠 화학적 구조와의 상관관계를 파악. 이러한 연구결과로 국내 연안의 해양생뭉의 천연물개발 가능성을 입증하였으며 해양신물질 개발을 위한 기반을 확립하고 향후의 산업화를 위한 생물 및 천연물 소재를 확보하였음.
Abstract▼
Research on metabolites of marine organisms has significant importance on both academic and industrial aspects of science and technology. Information on natural Products as well as organisms producing them provides an essential foundation for industrial research and development of chemisty and biote
Research on metabolites of marine organisms has significant importance on both academic and industrial aspects of science and technology. Information on natural Products as well as organisms producing them provides an essential foundation for industrial research and development of chemisty and biotechnology. Knowledge on the metabolites of marine organisms also contributes trmendously to the progress of many related fields including valuable information, resaerch tools, and targets for both basic and applied researches. Acknowledging the great potential of marine natural products, leading countries regard research on this field as one of the major natural part of biotechnology in 21st centry, and have put enormous efforts into the research and development of marine-derives substances. Consequently the numbers of novel compounds derived from marine organisms have reached 15,000 and this field has progressed exponentially in last few decades. A great many compounds exhibit potent and diverse bioactivities as well as unique mode of action which enables them to be xelected as attractive targets for chemical and biomedical works. Several compounds are currently in the process of development for industrical uses such as drugs, agrochemicals, cosmetics, and health-care products. Leading compounds are already commercially avaialble or expected to appear in the market in the near future. Despite the great abundance and diversity of marine lifes in the nearby seas, however, marine natural products have never been selected as the main objectives of biomedical or related research in Korea sine effors have been confined only on traditional folk medicines and microorganisms of terrestrial origin. Considering the tremendous potential of marine natural products in the future, also considering the relationship of marin natural products chemistry with many fields of science, research on marine natural products abd organisms producing them is among the biotechnological fields of great urgency in Korea. Based on the results of previous exploratory studies on metabolites of benthic organisms and microbes from marine environment, the ultimate objective of this project is the development of novel marine natural products possissing potentials for biomedical or other uses. Organisms producing efficiently these mebolites will be also defined and developed. On the meanwhile, improvement on the chemical and biological techniques dealing with marine organisms and their metabolites is also pursued. Special emphasis goes to those for the isolation and structure determination of complex orgarnic molecules, chemical transformation of natural products, total synthesis and/or semi-synthesis of bioactive metabolites, screening methods for bioactivity, as well as the isolation and cultivation of marine microbes. Thus, this project privides not only materials for industrial develpment but also technical basis forthe advanced research on marine natural products chemistry and biotechnology. During the three years of ths research, effort is focussed on the initial part of natural product research. That goes to the systematic collection of marine organisms from various environment as well as the isolation and structure determination of novel substances from selected organisms based upon chemical analysis and bioassay. In addition, emphasis goes to the synthsis of novel bioactive analogs from natural products and development of efficient methods for mass-isolation of lead compounds.
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