초록

1.연구개발의 최종목표와 내용
- 다양한 곤충자원으로부터 곤충의 섭식특성을 고려한 공생미생물의 효소자원 및 유용생리활성물질 자원의 확보, 활성검정, 특성규명 및 대량생산을 통한 산업적 활용 연구.
- 약용곤충 및 자원으로부터 도출된 생리활성물질에 대한 in vitro, in vivo 효능과 안전성 검정, 작용기작 규명을 통해 선별한 후보물질 또는 활성분획을 이용하여 성인병의 예방, 치료용 기능성식품 또는 식품의약 개발과 곤충으로부터 분리된 공생미생물의 산업적 이용기술을 개발, 기술 이전 및 실용화 연구

Abstract ▼

Insect constitutes the largest group of extant orgamsm, and perhaps their individual number account for as 80% of all known fauna and are important components of the natural ecosystem. Therefore, they are suggested to be a useful sources of bio-active materials. At this research we tried to screen s

Insect constitutes the largest group of extant orgamsm, and perhaps their individual number account for as 80% of all known fauna and are important components of the natural ecosystem. Therefore, they are suggested to be a useful sources of bio-active materials. At this research we tried to screen some digestive enzymes and anti-atherosclerotic materials from the insect resources and microbes that are related to insect.
Lipases [EC 3.1.1.3] catalyze the hydrolysis of triglyceride at the interface between the insoluble substrate and water. They are ubiquitous in nature and are produced by various animals, plants, fungi, bacteria and archia. Among them, extracellular bacterial lipases are of considerable commercial importance, because of their diverse substrate specificity, stero-specificity, and tolerance against heat and various organic solvents so, they are widely used in food technology, detergent, chemical industry and biomedical SCiences. Digestive tracts of insects contain a complex biota comprising both resident and transient members from bacterial, fungal, protoroan, and archaeal strains. Insects rely on microbes for various physiological functions, including food digestion, nutrition, nitrogen fixation, and pheromone production. Here, we tried to isolate a lipase producing microbe by culture-based screening that is focused on the dietary preference of the insect which believed as a valuable tools for fmding unique exo-enzyme producing microorganisms. Cardiovascular diseases occupy 30-40% of overall mortality rate. Obesity, hyperlipidaemia, and atherosclerosis are accounted for major lisk factors of coronary heart disease, a leading cause of death. The worldwide market scale of medicines for cardiovascular disease reaches to 65 billion dollars yearly. Despite increased detection and treatm.ent of hypertension and hyperlipidaemia, incidence of atherosclerotic disease remains high. Many medicines for hypercholesterolemia and atherosclerosis have been developed but they are very expensive and must be taken carefully with a doctor's prescription due to the possible side effects and so forth.

목차 Contents

• 표지 ...1
• 제출문 ...3
• 요약문 ...5
• SUMMARY ...15
• CONTENTS ...23
• 목차 ...25
• 제 1 장 서론 ...27
• 제 2 장 국내외 기술개발 현황 ...31
• 제 1 절 국외 기술개발 현황 ...31
• 제 2 절 국내 기술개발 현황 ...33
• 제 3 장 연구개발수행 내용 및 결과 ...35
• 제 1 절 곤충 공생미생물의 산업적 이용 기술 개발 ...35
• 제 2 절 곤충자원 유래 기능성 식품소재 탐색 및 이용기술 개발 ...66
• 제 4 장 연구개발목표 달성도 및 대외기여도 ...132
• 제 5 장 연구개발결과의 활용계획 ...135
• 제 6 장 기타 중요 변동사항 ...137
• 제 7 장 참고 문헌 ...138