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본 연구는 노화성 근감소증 제어를 위한 신규 운동 효과 물질 개발 임상 중개 연구로 신규 분자표적을 발굴하고 운동 효과 물질에 대한 임상 시험을 수행하기 위한 협동 연구로 진행되었음. 본 세부는 근육세포의 근감소증 노화모델에서 노화마...

본 연구는 노화성 근감소증 제어를 위한 신규 운동 효과 물질 개발 임상 중개 연구로 신규 분자표적을 발굴하고 운동 효과 물질에 대한 임상 시험을 수행하기 위한 협동 연구로 진행되었음. 본 세부는 근육세포의 근감소증 노화모델에서 노화마커 검증 연구를 수행하였고, 한센인을 대상으로한 DDS의 근감소증 임상연구를 실시하였음.
또한 대사증후군 동물모델에서 myokine 기능분석을 완료하였음. 1세부에서 최종선정한 근육분화 촉진약물에 대한 연구자임상 IRB 승인을 완료하여 2단계에 임상 연구를 수행할 예정

Abstract
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Development of platforms for therapeutic technologies to control muscle aging
○ This study was designed to ensure the extended ...

Development of platforms for therapeutic technologies to control muscle aging
○ This study was designed to ensure the extended healthy life of the elderly population. As research projects to achieve this purpose, the studies were undertaken to develop of platforms for therapeutic technologies to control muscle aging and regenerate the aged muscle tissues.
- Project 2: Translational research for development of exercise mimetics for control of sarcopenia
○ Population of Korea has been experienced unprecedented aging process with the world's highest rate, which accompanied a steep decline in the economic productivity. In order to solve this national problem, it is required to ensure the extended healthy life of elderly population, which could reduce the cost of health care and make the elderly to participate in economic activities.
Translational research for development of exercise mimetics for control of sarcopenia
○ The purpose of this study is to validate the effect of the lead compounds for treatments of sarcopenia. In particular, this study is aimed at investigating whether the lead compounds restore muscle mass and function by clinical research in humans. The discovery of novel molecular targets and the identification of therapeutics for sarcopenia, which helps solve human sarcopenia.
- Investigation of molecular mechanisms of caveolin-1 regulating sarcopenia using DEX induced muscle atrophy models
- Clinical research for validation of efficacies of the lead compounds
- Discovery of myokines as diagnostic markers for sarcopenia

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