Abstract ▼

Purpose&contents
● Purpose of study
- on mechanism for development of effective chemotherapeutic agents which are useful for oral cancer treatment
- understanding on chemoresistance mechanism of hypoxic oral cancer cells which are focused on autophagy
- strategy for increaseng the effica

Purpose&contents
● Purpose of study
- on mechanism for development of effective chemotherapeutic agents which are useful for oral cancer treatment
- understanding on chemoresistance mechanism of hypoxic oral cancer cells which are focused on autophagy
- strategy for increaseng the efficacy of chemotherapeutic agents
- identification of drugs which can suppress invasive and metastatic capability of oral cancer cells
● Contents of study
- confirmation on usefulnesss of autophagy control in oral cancer treatment
- effects of oral inflammation-related microorganism derived from tumor microenvironment on the proliferation and/or survival of oral cancer cells
- effects of chronic periodontitis-related microorganism on the cycle progression of oral cancer cell cycle
Result
● first year
- study on the mechanism of autophagy activation in oral cancer cells
- interrelation between autophagy and survival of oral cancer cells
- identification on the role of tumor suppressive autophagy in chemoresistance
● second year
- study on oral inflammation-oral cancers based on the analysis on the correlation between chronic inflammation and cancer
- analysis on the interrelation between chronic periodontitis and oral cancers
- establishment of strategy to use P. gingivalis, which is a major etiologic agent in tumor microenvironment, in oral cancer study
- effects of P. gingivalis on the survival and proliferation of oral cancer cells
● third year
- identification on autophagy induction of oral cancer cells by chronic oral inflammation
- effect of inflammatory stimuli on the proliferation and aggressiveness of oral cancer cells
Expected Contribution
● identification on the role of chronic periodontitis including P. gingivalis in the development of oral cancers
- effects of intracellular changes exposed to inflammatory stimuli on metabolism and phenotypic changes of oral cancer cells
- effects of intracellular changes on tumor microenvironment
- changes in biologic behaviors of oral cancer cells which have been exposed to P. gingivalis

목차 Contents

• 핵심연구사업 최종보고서(평가용) ... 1
• 목 차 ... 3
• 연구계획 요약문 ... 4
• 연구결과 요약문 ... 5
• 한글요약문 ... 5
• SUMMARY ... 6
• 연구내용 및 결과 ... 7
• 1. 연구개발과제의 개요 ... 7
• 2. 국내외 기술개발 현황 ... 8
• 3. 연구수행 내용 및 결과 ... 9
• 4. 목표달성도 및 관련분야에의 기여도 ... 21
• 5. 연구결과의 활용계획 ... 23
• 6. 연구과정에서 수집한 해외과학기술정보 ... 24
• 7. 주관연구책임자 대표적 연구실적 ... 25
• 8. 참고문헌 ... 25
• 9. 연구성과 ... 27
• 10. 기타사항 ... 27
• 끝페이지 ... 33