초록 ▼

1. 문헌분석 및 전문가합의를 통한 비기허증 주요증후를 추출하고 중요도를 도출하여, < 비기허증 진단평가도구 >를 제작하였고,임상연구를 실시하여 신뢰도 및 타당
2. 도를 검증하고, 비기허증 진단을 위한 cutoff value를 확보하였음.
3. 비기허증 gut hormone profiling 모델구축을 위한 임상연구를 실시하여, 정상인군과 다른 비기허증군의 특징적인 gut hormone 패턴을 탐색하였음.
4. 비기허증 환자에 대한 향사육군자탕 투여 무작위배정, 위약대조, 이중맹검, 평행군 임상시험를 실시하여, <

1. 문헌분석 및 전문가합의를 통한 비기허증 주요증후를 추출하고 중요도를 도출하여, < 비기허증 진단평가도구 >를 제작하였고,임상연구를 실시하여 신뢰도 및 타당
2. 도를 검증하고, 비기허증 진단을 위한 cutoff value를 확보하였음.
3. 비기허증 gut hormone profiling 모델구축을 위한 임상연구를 실시하여, 정상인군과 다른 비기허증군의 특징적인 gut hormone 패턴을 탐색하였음.
4. 비기허증 환자에 대한 향사육군자탕 투여 무작위배정, 위약대조, 이중맹검, 평행군 임상시험를 실시하여, < 비기허증 진단평가도구 >의 진단 및 치료평가도구로서의 타당성을 확인하고, 비기허증 치료처방의 효능과 관련된 특징적인 gut hormone의 변화인 식사 전후 PYY의 감소를 탐색하였음.

Abstract ▼

< Purpose >
-To construct gut hormone profiling model which could explain clinical factors of spleen qi deficiency syndrome and to establish efficacy evaluation techniques for treatment of spleen qi deficiency syndrome.
< contents >
-Development of a standard instrument of diagnosis and ass

< Purpose >
-To construct gut hormone profiling model which could explain clinical factors of spleen qi deficiency syndrome and to establish efficacy evaluation techniques for treatment of spleen qi deficiency syndrome.
< contents >
-Development of a standard instrument of diagnosis and assessment for spleen qi deficiency syndrome and its severity
-Construction of gut hormone profiling model which could explain clinical factors of spleen qi deficiency syndrome
-Exploration of the effect of Hyangsayukgunja-tang (representative prescription of spleen qi deficiency syndrome) on the clinical factors and gut hormone profiling of patients with spleen qi deficiency syndrome.
-Suggestion of efficacy evaluation techniques for treatment of spleen qi deficiency syndrome.
< Results >
-Standard instrument of diagnosis and assessment of spleen qi deficiency was completed after assessment of references and reflection of opinions by expert committee to select major symptoms of spleen qi deficiency syndrome.
-Performed clinical study to develop standard instrument of diagnosis and assessment of spleen qi deficiency and verified its reliability and validity and ensured optimum cut-off value.
-Performed clinical study to construct gut hormone profiling model, and explored distinguished gut hormone pattern in spleen qi deficiency syndrome group compared to healthy group.
-Performed clinical trial of the effect of Hyangsayukgunja-tang on patients with spleen qi deficiency syndrome; randomization, placebo-controlled, double-blind, parallel trial. As a result, we verified the validity of standard instrument of diagnosis and assessment of spleen qi deficiency and explored the pre-post prandial reduction of plasma PYY which is related to efficacy of treatment of spleen qi deficiency syndrome.
< expected contribution >
-Foundation of clinical research for application of SQDQ and evaluation methods of gut hormone to evaluate efficacy of traditional medicine.
-Application of methods of study on another traditional Korean medicine so contribute to develop diagnosis and treatment evaluation tool.
-Application of standard instrument of diagnosis and assessment of spleen qi deficiency in clinics so make it easy to diagnose and evaluate the treatment efficacy.