초록 ▼

1) 해외자생식물 12,500개의 추출물에서 에스트로겐성이 우수한 효능의 식물을 스크리닝하고 대량생산과 제품화가 용이한 아시아권 후보 식물 7종을 선별하여 이에 대하여 여성호르몬성 약리작용 확립 및 기전을 연구하였음.
2) 선별된 7종 식물 추출물에 분획, 단일 성분을 연구하여 지표성분을 선정하였으며 향후 제품화시 일정한 약리효능 유지 및 안전성 확립을 위한 자료를 확보함.
3) 후보식물들의 neuroglobin 증진을 통한 신경보호 작용, 대사성 blood profile 개선 효능, 활성 평가 등의 효능확대연구를 통하여

1) 해외자생식물 12,500개의 추출물에서 에스트로겐성이 우수한 효능의 식물을 스크리닝하고 대량생산과 제품화가 용이한 아시아권 후보 식물 7종을 선별하여 이에 대하여 여성호르몬성 약리작용 확립 및 기전을 연구하였음.
2) 선별된 7종 식물 추출물에 분획, 단일 성분을 연구하여 지표성분을 선정하였으며 향후 제품화시 일정한 약리효능 유지 및 안전성 확립을 위한 자료를 확보함.
3) 후보식물들의 neuroglobin 증진을 통한 신경보호 작용, 대사성 blood profile 개선 효능, 활성 평가 등의 효능확대연구를 통하여 적응증을 확대 연구 수행.
4) 분리 동정된 단일성분의 활성 대사체 검출 및 간대사 안정성을 평가하여 높은 생체안전성(safety)과 간대사안정성(liver metabolic stability)을 확인하였음. 생쥐를 대상으로 급성독성시험을 실시하였을 생체독성에 대한 예비 안전성이 우수한 것을 확인함.
5) 후보 식물의 산업화 개발을 위하여 관련 회사들과의 파트러닝 진행 중임. 향후 여성 폐경기 증후군 개선을 위한 건강 의약품 및 기능성식품, 또는 뷰티 신소재 개발을 위한 제품화 촉진 수행.

Abstract ▼

Results
1. Screening estrogenic plants among 12,500 foreign plants, and 7 selected plants (Asian plants that are available for large harvesting) were tested pharmacological evaluation and mechanism using in vivo and in vitro system.
2. Selected 7 plants were analyzed by HPLC, and confirmed act

Results
1. Screening estrogenic plants among 12,500 foreign plants, and 7 selected plants (Asian plants that are available for large harvesting) were tested pharmacological evaluation and mechanism using in vivo and in vitro system.
2. Selected 7 plants were analyzed by HPLC, and confirmed active single compounds using MS, NMR. These compounds indicate standard components for the development of new durgs, functional food, or beauty materials.
3. As s clinical efficacy application study, improved blood profiles of triglyceride, enhanced neuroglobin promoter activity, anti-inflammatoryefficacies via inhibition of HDPGS were confirmed by in vivo and in vitro system.
4. For the evaluation of preclinical candidates, metabolic stability and toxicity evaluation were executed using acute toxicity by single administration, and active metabolites and liver metabolic stability. These results showed that our candidates showed high stability and safety and suitable as candidates for the drug developments.
5. For the industrial development of the selected plants for women’s disease, we are searching for partnering company, which would promote the chance for developing new drugs, functional foods or beauty materials.

< Patents >
1. A composition comprising Larrea cuneifolia Cav. for the prevention and treatment of menopausal symptom (registration 10-1348471).
2. Pharmaceutical compositions for prevention and treatment of cancer and menopausal symptom of women containing isolated compound from Larrea nitida or the pharmaceutically acceptable salts as an active ingredient(registration 10-1580716).
3. Pharmaceutical compositions for prevention and treatment of cancer and menopausal symptom of women containing isolated compound from Larrea nitida or the pharmaceutically acceptable salts as an active ingredient(application PCT/KR2014/000401)
4. Pharmaceutical compositions for prevention and treatment of cancer and menopausal symptom of women containing Cajanus cajan (L.) Huth extract or its fraction as an active ingredient (application 10-2015-0142742).
5. Pharmaceutical compositions for prevention and treatment of cancer and menopausal symptom of women containing Flemingia strobilifera or its isolated compound as an active ingredient (application 10-2015-0142736).
6. Pharmaceutical compositions for prevention and treatment of cancer and menopausal symptom of women containing isolated compound from Platanus acerifolia or its isolated compound as an active ingredient (application 10-2015-0142720).
7. Pharmaceutical compositions for prevention and treatment of cancer and menopausal symptom of women containing Prunus cerasoides, the pharmaceutically acceptable salts or fraction comprising it as an active ingredient (application 10-2015-0142714).

< Publications >
1. Hye-Na Ahn, Si-Yeon Jeong, Gyu-Un Bae, Minsun Chang, Dongwei Zhang, Xiyuan Liu, Yihua Pei, Young-Won Chin, Joongku Lee, Sei-Ryang Oh, YunSeon Song, Selective estrogen receptor modulation by larrea nitida on MCF7 cell proliferation and immature rat uterus. Biomolecules & Therapeutics, 22, 347, 2014.
2. Si-Yeon Jeong, Hye-Na Ahn, Gyu-Un Bae, Minsun Chang, Xiyuan Liu, Hee-Kyung Rhee, Joongku Lee, Young-Won Chin, Sei-Ryang Oh, Yun SeonSong, Isoguaiacins, arylnapthalene types identified as novel potent estrogenic signaling molecules from Larrea nitida. Bullentin of the Korean Chemical Society, 39, 2254, 2015.
3. Si-Yeon Jeong, Raok Jeon, Yoon Kyung Choi, Joo Eun Jung, Anna Liang, Changhong Xing, Xiaoying Wang, Eng H. Lo, Yun Seon Song, Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia, J. Neurochemistry, 136, 851, 2015.