초록 ▼

최근 연구되고 있는 기능성 근적외선 분광기법 (functional near infrared spectroscopy: fNIRS)을 통해 뇌혈류의 양과 산소포화도를 실시간으로 모니터링 할 수 있지만 응급상황이나 인큐베이터 등에서 상시적으로 사용하기에는 장비 부피가 커 힘들며 고가의 장비이다. 또한 현존하는 fNIRS 분석 기법으로는 MRI, PET 등과 견줄만한 최소한의 분석 유용성 및 해상도를 가지는 데이터를 얻기가 어렵다. 따라서 fNIRS 용 ASIC을 개발함으로써 타사의 장비와 비교했을 때 뛰어난 소형화 시스템 제작 하였으며

최근 연구되고 있는 기능성 근적외선 분광기법 (functional near infrared spectroscopy: fNIRS)을 통해 뇌혈류의 양과 산소포화도를 실시간으로 모니터링 할 수 있지만 응급상황이나 인큐베이터 등에서 상시적으로 사용하기에는 장비 부피가 커 힘들며 고가의 장비이다. 또한 현존하는 fNIRS 분석 기법으로는 MRI, PET 등과 견줄만한 최소한의 분석 유용성 및 해상도를 가지는 데이터를 얻기가 어렵다. 따라서 fNIRS 용 ASIC을 개발함으로써 타사의 장비와 비교했을 때 뛰어난 소형화 시스템 제작 하였으며 통신 및 광통신에서 사용되는 CDMA & MIMO 기술을 기반으로 DOT 알고리즘을 통해 고해상도 생체 신호 해석이 가능 가능하였다. 또한 통계 신호처리를 이용하여 뇌 활성영역을 검출하고, 고해상도 영상이 가능한 압축센싱 기반 3차원 고해상도 영상 재구성 알고리듬을 개발하였다. 추가적으로 뇌 네트워크 분석을 이용한 진단 기법을 개발하여 최종적으로 fNIRS 신호 분석, 영상화, 혈류 및 산소포화도 변화 측정 및 혈관 질환 진단이 가능한 통합 분석도구를 개발한다.

(출처 : 보고서 요약서 3p)

Abstract ▼

Purpose & Contents
As the population becomes aging and lifestyle and diet are becoming more and more Western, patients of cerebrovascular disease, such as stroke, cerebral hemorrhage, and cerebral infarction, increase rapidly. Also, the preterm birth rate continues to climb since modern women mar

Purpose & Contents
As the population becomes aging and lifestyle and diet are becoming more and more Western, patients of cerebrovascular disease, such as stroke, cerebral hemorrhage, and cerebral infarction, increase rapidly. Also, the preterm birth rate continues to climb since modern women marry late in life. By the latest monitoring technology, Functional Near-Infrared Spectroscopy (fNIRS), cerebral blood flow (CBF) and oxygen saturation can be monitored in real time. Recent fNIRS device, however, is too bulky and expensive to use it as monitoring device on a permanent basis in emergency situation, incubator, and so on. Therefore, this study attempts to develop portable, customized, and low-priced fNIRS imager and apply the technique in various medical situations.

In order to obtain a biological and physiological data from fNIRS system with a high-resolution image for clinical application, the measured signal should be processed with a signal processing technique for overcoming the cause of a number of signal degradation. The purposes of this research team are developing a portable fNIRS system through fNIRS IC to minimize the size and applying DOT techniques for the high resolution data reconstruction based on the algorithm of MIMO and CDMA. Additionally, we develop quantitative indicator and statistical analysis tool for these situations and reconstruct a high resolution brain activity image using fNIRS. Performance verification of this system will process through organic collaboration with the hospital aim to commercialize the product.

Results
Developing NIRS ASIC for underlying the portable fNIRS equipment as compared to the other conventional equipment, miniaturizes the whole system by integrating the entire circuit on a single IC of 5mm by 5mm size and the minimum measurable signal is about 400fW. It is likely two times more than the performance of commercial product.

The portable high resolution fNIRS system is developed through communication, and optical communication techniques with a high-performance software capable of bio-signal analysis. New theoretical approaches and the prototype implementations are efficient to improve the performance requirements for such discomfort that occurs when actual measurements were possible. For the prototype measures 204 brain regions simultaneously with 0.4cm spatial resolution and capable of varying the time resolution and spatial resolution to 32Hz at 8.13Hz.

By applying compressed sensing into the fNIRS data, we found that our method outperformed the conventional methods in locating the active brain area. Furthermore, it could provide accurate and quantified results by using random effect model with statistical analysis. Under the same condition (p-value<0.05), our method showed more accurate results than the conventional methods. Even though it is hard to reconstruct the source which is in the deep brain area, our method succeeded to recover the results until 0dB SNR.

We established the method which can provide the reference images of the blood flows in the brain by accelerating T2’ mapping method. By 12.8 times accelerating the multiecho-spinecho method, imaging time reduced from 13 minutes to 1 minute so that it is possible to obtain a high resolution mapping in a short time period. Furthermore, multiecho-gradient method can also be accelerated 8 times faster than before so that we could reduce the total time cost for high resolution T2’ mapping from 26 minutes to less than 3 minutes. fNIRS:

Expected Contribution
By first developing a low cost, high quality, portable, and wirelss fNIRS system, we can pioneer the new market for this area. This system enables us the online and regular monitoring of the brain which will facilitate the diagnosis of brain diseases. Moreover, we can minimize the brain demage during the evacuation or in the hospital by providing a cheap and entirely portable brain monitoring system with high resolution. We alkso expect that this system could be used with brain computer interface to rehabilitate the quadriplegia patients.

(출처 : SUMMARY 7p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 요약문 ... 4
• SUMMARY ... 6
• Table of Contents ... 8
• 목차 ... 8
• 제1장. 연구개발과제의 개요 ... 9
• 1. 연구개발 목적 ... 9
• 2. 연구개발의 필요성 ... 9
• 3. 연구개발 범위 ... 10
• 제2장. 국내외 기술 개발 현황 ... 11
• 제3장. 연구 수행 내용 및 성과 ... 14
• 제4장. 목표 달성도 및 관련 분야 기여도 ... 48
• 제5장. 연구개발성과의 활용계획 ... 48
• 제6장. 연구 과정에서 수집한 해외 과학기술 정보 ... 49
• 제7장. 연구개발성과의 보안등급 ... 49
• 제8장. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 49
• 제9장. 연구개발과제 수행에 따른 연구실 등의 안전 조치 이행 실적 ... 49
• 제10장. 연구개발과제의 대표적 연구 실적 ... 50
• 제11장. 기타 사항 ... 53
• 제12장. 참고 문헌 ... 53
• 끝페이지 ... 54