초록 ▼

1) 테라헤르츠 대역 분광지문을 이용한 식품오염물질의 검출기술 개발 (1세부)
○ 데이터베이스용 테라헤르츠 (THz) 대역 분광지문 확보 및 DB화 (200건 이상)
○ 분자계산에 의한 진동주파수 데이터 축적 (범 밀도 함수 이론 이용) 및 특이지문 추출
○ 특이지문을 이용한 식품 오염인자의 비파괴 검출 기술 개발
▪ 밀가루 및 분유 중 혼입 멜라민 측정 (LOD 2.8-3.8%)/현장 유사환경에서 대량 제조된 초콜렛 중 멜라민 측정 (포장상태에서 약 1%까지 검출)/밀가루 중 메소밀 측정 (LOD

1) 테라헤르츠 대역 분광지문을 이용한 식품오염물질의 검출기술 개발 (1세부)
○ 데이터베이스용 테라헤르츠 (THz) 대역 분광지문 확보 및 DB화 (200건 이상)
○ 분자계산에 의한 진동주파수 데이터 축적 (범 밀도 함수 이론 이용) 및 특이지문 추출
○ 특이지문을 이용한 식품 오염인자의 비파괴 검출 기술 개발
▪ 밀가루 및 분유 중 혼입 멜라민 측정 (LOD 2.8-3.8%)/현장 유사환경에서 대량 제조된 초콜렛 중 멜라민 측정 (포장상태에서 약 1%까지 검출)/밀가루 중 메소밀 측정 (LOD 4.7%)/위변조된 주류 및 참기름의 검출 가능성 조사/시중 건강기능식품 비타민 C 제품 (80%)의 비파괴적 측정 (1-2분 이내 신속 측정: 80.16±2.49%, RSD 3.2%)
○ 테라헤르츠 대역 검출감도 향상 기술 개발
▪ 2종 반응물질 제작 및 평가/감도향상 플라즈모닉 구조체 (마이크로 및 나노갭 구조의 slot antenna 이용) 제작 및 평가(100배 이상 감도 향상)/THz 대역 라만 검출감도의 증가를 위한 SERS기판 제작 및 평가
○ 휴대형 테라헤르츠 분광기 시작품의 검출능력 평가 (상용제품과의 비교 및 재현성 평가)

2) 인간 후각 및 미각 인지 기반 냄새․맛 지문 인식기술 개발(2세부)
○ 식품 오염인자를 감지하는 고민감도 인공후각/미각 센서 개발
▪ 곡류 곰팡이 오염 검출용 액상 후각 센서 개발 (검지한계농도 1 fM)/해산물 (굴) 오염 검출용 액상 후각 센서 개발 (검지한계농도 10 fM)/우유 신선도 측정용 액상 후각 센서 개발 (검지한계농도 1 fM)/갑상선종 유발 채소류 독소 검출 미각 센서 개발 (검지 한계농도 100 pM)/해산물 오염 검출용 기상 후각 센서 개발(검지한계농도 10 ppt)/육류 살모넬라균 오염 검출용 액상 후각 센서 개발 (검지한계농도 1 fM)
○ 다채널 센서 개발
▪ 4종류 식품, 4개 오염인자에 대한 검지가 가능한 4X4 어레이 타입 센서 개발
○ 식품의 오염도 및 신선도 측정용 표준화 시스템 개발
▪ 인간의 후/미각 시스템을 이용한 냄새 및 맛 지문인지 시스템 구축

3) 식품 중 오염물질의 현장감시를 위한 포터블 테라헤르츠 분광기 기술 개발(3세부)
○ 광대역 DML (Dual-Mode Laser) 개발
▪ 출력: >20 mW, 증폭기 집적형 DML 설계, 공정, 칩 제작, 패키지 모듈/파장제어 및 모니터링 기술
○ 광대역 매립형 포토믹서 모듈 개발
▪ 광대역 매립형 포토믹서 칩 및 모듈 기술 개발
○ THz 발생 및 검출 기술 및 포터블 고감도 테라헤르츠 분광기 개발
▪ 주파수 가변범위 >1.5 THz 이상 (연속파기준), >2.0 THz (PCA기준) SNR: >70 dB＠300 GHz, >30 dB@1 THz
▪ 무게: <3 kg, Coarse/Fine scan mode 기술 포함
▪ Resolution: <1 GHz, Scan time: <2 min@1 THz

(출처 : 보고서 요약서 3p)

Abstract ▼

Ⅳ. Results of the research
A. Development of detection technology for food contaminants based on spectral fingerprints in the terahertz region
○ Construction of DB system and acquisition of spectral data
- More than 200 spectral data were measured by THz-TDS and/or Raman spectroscopy with

Ⅳ. Results of the research
A. Development of detection technology for food contaminants based on spectral fingerprints in the terahertz region
○ Construction of DB system and acquisition of spectral data
- More than 200 spectral data were measured by THz-TDS and/or Raman spectroscopy with respect to food contaminants. These data were accumulated in the THz databases named "Tera Food Contaminants Inspection Data Management System (TeraFCIMS) for future practical databases.

○ Identification and analysis of fingerprint peak in THz absorption spectrum with solid-state density funtional theory calculation.
- To obtain the fingerprint for detecting food contaminants, the vibrational frequency and intensity of food contaminants were calculated with solid-state density functional theory. After the theoretical spectrum was compared with the experimental spectrum, the individual absorption modes were analyzed and selected the fingerprint for detecting food contaminants.

○ The non-destructive/non-invasive analysis of food contaminants using contaminant specific fingerprint
- The specific fingerprints obtained were applied to the rapid detection of food contaminants/adulterants. Melamine in milk and wheat flours was detectable from those of food components in a dose-dependent manner at 2 THz, irrespective of packaging material with detection limit of 2.8-3.8%. In addition, melamine in mass-produced chocolate products was detected with detection limit of 1%. Methomyl, a pesticide, was dose-dependently distinguishable from that of wheat and rice flours by using the peak appearing at 1 THz (33.4 cm^–1) as the fingerprint. The calibration curve of methomyl had a regression coefficient (R²) of >0.957 and a detection limit of 4.7%. Accuracy and precision expressed as recovery and relative standard deviation in inter day repeatability were in the ranges 78.0–96.5% and 2.83–4.98%, respectively. Whisky diluted with water was discriminated, up to the 2.63% level, but not detected the adulteration of whisky with the cheaper one. Various types of refined oils were successfully discriminated based refractive indices and absorption coefficients measured by THz-TDS, but not detected the adulteration of sesame oil with the cheaper one. The contents (80%) of vitamin C in commercially available dietary supplements were nondestructively analyzed (80.16±2.49%) by using THz-TDS with a relative standard deviation of 3.2%. The accuracy and precision of a THz-TDS analysis for vitamin C was better or comparable with those of HPLC analysis almost the same as that of an unwrapped sample. Overall, these results suggest that THz-TDS has the potential to be used for the rapid detection of contaminants or adulterants in food.

○ Development of technology for detection signal enhancement in the THz region
- To generate an amplified THz signal through the interaction between the organic molecules and the host materials, single molecules containing specific functional groups have been inserted into porous materials such as a metal-organic framework and a zeolite. Melamine and cyanuric acid have been inserted into the pores of HKUST-1 and MCM-41. The complexes were structurally characterized by X-ray diffraction and identified by SEM/EDAX and FT-IR spectroscopy. More sensitive and effective Terahertz signals have been monitored and peaks generated from the inserted complexes have been successfully assigned. To develop novel sensing techniques for the highly sensitive detection of hazardous chemicals, plasmonic structures of micro - and nano-gap slot antenna arrays were employed. As a results, the enhanced sensitivities of more than 100 times for methomyl was achieved. The THz slot antenna structures also were applied for the on-site detection of the micro-sized microorganisms such as bacteria and fungi. In addition, signal enhancement (a few ppb) was observed by employment of surface enhanced Raman scattering (SERS) substrate developed in this research.

○ Performance test for prototype portable THz spectrometer
- The performance of prototype portable THz spectrometer developed in this project (sub-project 3) was tested. For instances, the characteristic THz absorption peaks (1.99 and 2.25 THz) of methomyl at room temperature detected with prototype portable THz spectrometer were comparable with those detected with the commercial THz-TDS systems (Advantest or Teraview Inc.). The spectrum was also reproducibly obtained.

B. Development of Food Contamination Detection Technique Using Human Olfactory and Taste Receptor
○ Development of supersensitive liquid/gas phase sensor for the detection of food contamination indicator
- Olfactory biosensor for detection of fungal contamination in grain (LOD 1 fM)
- Olfactory biosensor for detection of seafood decomposition (LOD 10 fM)
- Olfactory biosensor for detection of lipid oxidation (LOD 1 fM)
- Taste biosensor for detection of antithyroid toxin in vegetable (LOD 100 pM)
- Olfactory biosensor for detection of seafood decomposition in gas phase (LOD 10 ppt)
- Olfactory biosensor for detection of salmonella contamination in beef (LOD 1 fM)

○ Development of multi-channel biosensor
- Development of 4X4 array type sensor for detection of 4 kinds of food contamination indicators against 4 food samples

○ Development of standardization system for assessment of food quality
- Development of taste and smell recognition system using human olfactory and taste system

C. Development of a portable THz spectrometer based on photonics devices
○ Dual-mode semiconductor laser diode
- Development of the world's first widely tunable dual-mode laser diode with single cavity structure
- High-power SOA integrated 1.3 ㎛ dual-mode laser diode
- Design and Fabrication of SOA-DML with spot-size converter
- Frequency stabilization techniques for 1.3 ㎛-band dual-mode laser
- Dual-mode module module packaging

○ Photomixer performance improvement
- Optimization of material properties of LTG-InGaAs using MOCVD regrowth
- Optimization of material properties of LTG-InGaAs/InAlAs multilayer
- Improvement of photomixer performance using buried type photomixer
- Improvement of photomixer performance using multilayer structure
- Improvement of photo-conductive antenna performance using nano-electrodes
- Development CNT-based THz photo-conductive antenna

○ Photomixer module and THz pulse system
- Design and fabrication of the broadband antenna (Log-spiral, Log-periodic, Square-spiral)
- Development of compact optical fiber-pigtailed THz photomixer module
- Development of effectively heat-conductive THz photomixer module
- Development of THz pulse generator with a power of several hundred nW
- Development of fiber-coupled THz time-domain spectroscopy system with a bandwidth of 3 THz

○ Broadband THz wave generation & detection
- THz CW generation and detection based on 1.3 ㎛ DML (Operation frequency : 0.3 ~ 1.5THz)
- Frequency tuning range: >1.5 THz (CW), >3 THz (PCA)
- Signal-to-noise ratio: >80 dB＠300 GHz, >50 dB@1 THz
- Resolution: <0.5 GHz, Scan time: <2 min@1 THz
- Development of spectroscopic analysis technology using portable THz CW spectroscopy

(출처 : SUMMARY 13p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 요 약 문 ... 4
• SUMMARY ... 10
• CONTENTS ... 18
• 목차 ... 19
• 제 1 장 연구개발과제의 개요 ... 20
• 제 1 절 연구개발의 목적 및 필요성 ... 20
• 제 2 절 연구개발 목표 ... 26
• 제 3 절 해당단계 연구개발의 범위 ... 28
• 제 2 장 국내외 기술개발 현황 ... 32
• 제 1 절 국내․외 관련분야에 대한 기술개발현황 ... 32
• 제 2 절 연구결과가 국내․외 기술개발현황에 차지하는 위치 ... 35
• 제 3 장 연구개발수행 내용 및 결과 ... 37
• 제 1 절 이론적·실험적 접근방법 및 연구내용 ... 37
• 제 2 절 연구결과 ... 50
• 제 4 장 목표달성도 및 관련분야에의 기여도 ... 205
• 제 1 절 연도별 연구목표 및 평가착안점 ... 205
• 제 2 절 해당단계 연구개발 목표의 달성도 ... 208
• 제 3 절 기술 발전에의 기여도 ... 212
• 제 5 장 연구개발결과의 활용계획 ... 214
• 제 1 절 추가연구의 필요성 ... 214
• 제 2 절 타 연구에의 응용 ... 216
• 제 3 절 기업화 추진방안 ... 218
• 제 6 장 연구개발과정에서 수집한 해외과학기술정보 ... 219
• 제 7 장 연구시설‧장비 현황 ... 226
• 제 8 장 참고문헌 ... 228
• 끝페이지 ... 237