초록 ▼

■ 본 연구의 목적은 종양의 해부학적, 기능적 정보가 포함된 다중영상의 최적화를 위한 영상획득 기법을 개발하고, 생물학적 진단기술을 영상정합 기법으로 치료에 적용하여 진단/치료 통합시스템을 개발함.
■ MR 영상 및 기능영상을 CT영상에 맵핑할 수 있는 3차원영상정합 프로그램을 개발하고, 개발된 프로그램을 이용하여 MR영상 기법 (T1/T2/Diffusion imaging)에 따른 종양볼륨을 비교 평가함. 기능, 대사영상 치료융합 기반 및 응용기술 개발을 시행하는 동시에 동적영상 및 영상정합을 이용한 치료 융합신기술을 개발함.

■ 본 연구의 목적은 종양의 해부학적, 기능적 정보가 포함된 다중영상의 최적화를 위한 영상획득 기법을 개발하고, 생물학적 진단기술을 영상정합 기법으로 치료에 적용하여 진단/치료 통합시스템을 개발함.
■ MR 영상 및 기능영상을 CT영상에 맵핑할 수 있는 3차원영상정합 프로그램을 개발하고, 개발된 프로그램을 이용하여 MR영상 기법 (T1/T2/Diffusion imaging)에 따른 종양볼륨을 비교 평가함. 기능, 대사영상 치료융합 기반 및 응용기술 개발을 시행하는 동시에 동적영상 및 영상정합을 이용한 치료 융합신기술을 개발함. 이와 같은 연구개발을 기초로 하여 호흡신호를 이용한 4D CT영상 재구성을 최적화하고,동적장기 영상의 deformable registration 모듈을 개발함.
■ 다중영상기반 방사선수술용 영상자료획득조건 기초연구를 통해 임상의 방사선수술적응증 질환별 다중영상융합 프로토콜 개발 및 병소체적 결정 프로토콜 개발함.
■ 다중영상기반 생물학적 최적화 진단 및 치료 통합기술 분석을 위한 PET과 MRI 대사영상 활용 진단 및 방사선치료계획 최적화와 임상활용을 위해 영상 특성을 분석하고 최적화 프로토콜을 검증하였으며, 이를 활용하여 임상 적용하였음.

( 출처 : 보고서 요약서 3p )

Abstract ▼

IV. Research Results
1. Development of metabolic / functional MR image-based radiation treatment planning techniques
- High-resolution single-multi-voxel MR spectra could be obtained from normal animal brain using optimized parameters and pulse sequence. In addition, metabolites mapping of mul

IV. Research Results
1. Development of metabolic / functional MR image-based radiation treatment planning techniques
- High-resolution single-multi-voxel MR spectra could be obtained from normal animal brain using optimized parameters and pulse sequence. In addition, metabolites mapping of multi-voxel spectra enable us to visualize region-specific metabolic pattern.
- MR diffusion parameters like apparent diffusion coefficient (ADC), fractional anisotropy(FA), relative anisotropy (RA), and eigenvalues (λ1, λ2, λ3) were successfully quantified and mapped in rodent brain using optimized pulse sequence.
- Dynamic hepatocyte-specific contrast-enhanced MRI technique was successfully applied to assess the liver function that can provide valuable information for radiosurgery. The calculated parameter, hepatic extraction fraction (HEF) can be regarded as being marker of hepatic parenchymal function.
- Optimized magnetization transfer imaging technique provided us unique information about metabolic fluxes non-invasively in vivo. Considering magnetization transfer image can show structural damage and myelin loss, our optimized technique would be possible to classify tumor type in the near future.

2. Optimization of 3D multimodal images registration technique and clinical application of radiotherapy
- A program module was developed for 3D multimodal image registration. The program accepts input from DICOM images and performs 3D rigid body registration using an objective function of mutual information. The degree of registration was evaluated using a phantom study.
- A registration framework was implemented to register multimodal images and visualize the registration results.
- Using the developed registration prgram, tumor volumes were evaluated for different MR imaging (T1/T2/diffusion imaging).

3. Development of advanced metabolic / functional MR image-based radiation treatment planning techniques
- Radiation treatment planning was performed using MR spectroscopy imaging (MRSI) in prostate cancer patients. The target volumes were contoured in region of elevated metabolic level in MRSI.
- We developed fusion phantom that allow us to evaluate image registration accuracy. And the fusion phantom can be used in MRI-PET or PET-CT system.
- The functional MRI (i.e., BOLD EPI) that contains the information for movement/sensory verve can be applied to brain tumor patients. We developed basic practices to include fMRI information in radiation treatment planning.
- We exploited a graphic user interface (GUI) that is linked to LCModel software. The GUI can import the output files (i.e., “Coord“) of LCModel, and automatically calculate metabolic map. The calculated metabolic map can be overlaid with anatomical MR image (i.e., T1/T2 image).
- We developed an image registration toolkit (Matlab-based GUI) that can import multi-modality images (i.e., CT, MRI, MRSI) simultaneously.
- The polymer gel phantom that allow us to confirm 3D dose distribution was developed.
- The metabolic/functional MR image-based radiation treatment planning allow us to define tumor margin more accurately. That results in reducing normal tissue complications, thus improving radiotherapeutic efficiency.

4. Fundamental research for multi-modal image based radiosurgery.
- Design of anatomical head phantom that can used for optimal image acquisition technique.
- Optimal image conditions for malignant tumor in radiosurgery.
- Optimal image conditions for AVM in radiosurgery.
- Optimal image conditions for meningioma in radiosurgery.
- Optimal image conditions for high grade glioma in radiosurgery.

5. Development of radiation treatment techniques using dynamic image and image registration
- Developed the optimization technique reducing motion artifact in 3DCT image and evaluate the image quality using the irregular respiratory signal. (applying 5 case)
- Performance evaluation of optical flow and B-spline deformable registration algorithm under C++ language.
- Analysis of the 4DCT image affected by motion artifact using the phantom which could control target motion patterns and amplitude (applying 6 case).
- Developed the phantom for an accuracy verification and ontain the data that 0.4 mm accuracy under the case of 10 mm amplitude.
- Carry out the image registration and ADC, rCBV information mapping at the CT/MR functional fusion image (applying 3 case) and conduct comparison study of IMRT plan by using the factor of DVH and NTCP.

6. Development of diagnosis/treatment integrated system and MR image-based radiation therapy
- Reconstruction of particle path line and computation of 3D velocity map of whole brain using ECG-gating time-resolved 3D phase contrast MRI method
- Development of brain tumor modeling with human origin GBM cell line using stereotactic injection into nude mouse brain
- As previous studys for development of Hybrid MRI-LINAC system, verifiation of changes in the distribution of dose effect and the beam path of magnetic field using Geant 4 simulation
- Analysis of residual motion artifact in the phase easy to figure causes out.
- Implementation of accumulate dose evaluation from moving organ using average 4DCT image set and investigation to potential of clinical application as results of comparison error < 3% between measured dose and point dose using 2D array detector
- To determine the volume of tumor that has highly malignant by segmentation based on the pixel value in anatomical images and metabolic imaging parameter.

7. Development of enhanced diagnosis/treatment integrated system and MR image-based radiation therapy
- Implementation of error review and fused image by applying to the clinical application by developed 4D-MRI and 4D-flow MRI methods
- Introduction of monitoring techniques using MRI/MRS, and diffusion images in radiation treatment as an attempt to collect and analyze data
- Development of virtual simulation program with the optimized magnetic shielding simulation tool over the results of Geant 4 simulation about the effects of magnetic field
- Optimization of radiation therapy planning technique using biological parameters which are tumor control probability (TCP) and normal tissue complication probability (NTCP) based on equivalent uniform dose (EUD)
- Investigation to potential of development of the novel integrated diagnostic/therapy medical devices from simulation of dose delivery model in magnetic field

8. Development of multi-modal image fusion protocol for radiosurgery indications.
- Design of MRI/CT/Angio compatible phantom.
- Comparing multi-modal image fusion accuracy between BrainSCAN and Pinnacle.
- Image fusion protocol for radiosurgery of AVM and pituitary tumor.
- Development of optimal protocols.

( 출처 : SUMMARY 13p )

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 요약문 ... 5
• Summary ... 11
• CONTENTS ... 17
• 목차 ... 18
• 제1장 연구개발과제의 개요 ... 19
• 제1절 연구개발의 목적 ... 19
• 제 2절 연구개발의 필요성 및 범위 ... 19
• 제2장 국내외 기술개발 현황 ... 26
• 제 1절 국내외 기술개발 수준 ... 26
• 제 2절 국내외 연구현황 ... 28
• 제3장 연구개발수행 내용 및 결과 ... 30
• 제 1절 기능, 대사영상 획득 최적화 및 치료융합기반 기술 개발 ... 30
• 제 2절 3D 다중 영상정합 연구 및 치료적용기술개발 ... 42
• 제 3절 기능, 대사영상 치료융합 기반 기술 개발 ... 53
• 제 4절 기능, 대사영상 치료융합 응용기술 ... 66
• 제 5절 동적영상 및 영상정합을 이용한 치료 융합기술개발 ... 85
• 제 6절 자기공명영상 치료융합기반 및 진단/치료 통합시스템 기반 기술 개발 및 응용 ... 104
• 제 7절 다중영상기반 방사선수술용 영상자료획득조건 기초연구 ... 149
• 제 8절 임상의 방사선수술 적응증 질환별 다중영상융합 프로토콜 개발 ... 160
• 제 9절 다중영상기반 방사선수술의 병리를 고려한 병소체적 결정 프로토콜 개발 ... 169
• 제 10절 다중영상기반 방사선수술의 최적치료계획조건 개발 ... 175
• 제 11절 정상조직 보호위한 최적 치료계획모델 개발 ... 184
• 제 12절 다중영상기술기반방사선수술용 차세대 치료모델 개발 ... 194
• 제 13절 3D 다중 영상 기반 생물학적 최적화 방사선 치료기술개발 ... 199
• 제 14절 3D 다중 영상 기반 생물학적 최적화 방사선 치료기술 응용연구 ... 211
• 제 15절 다중 영상 기반 생물학적 최적화 방사선 치료기술 심화연구 ... 216
• 제 16절 4D 다중 영상 기반 생물학적 최적화 방사선 치료기술 기초연구 ... 228
• 제 17절 4D 다중 영상 기반 생물학적 최적화 방사선 치료기술 응용연구 ... 249
• 제 18절 다중영상 기반 생물학적 최적화 진단/치료 통합기술 개발 ... 276
• 제4장 목표달성도 및 관련분야에의 기여도 ... 314
• 제5장 연구개발결과의 활용계획 ... 321
• 제6장 연구개발과정에서 수집한 해외과학기술정보 ... 325
• 제7장 연구장비의 구축 및 활용 결과 ... 326
• 제8장 참고문헌 ... 327
• 대표성과기술서 ... 385
• 끝페이지 ... 390