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Kafe 바로가기주관연구기관 | 인트론바이오테크놀로지 |
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연구책임자 | 권안성 |
참여연구자 | 오동찬 |
보고서유형 | 최종보고서 |
발행국가 | 대한민국 |
언어 | 한국어 |
발행년월 | 2020-02 |
과제시작연도 | 2019 |
주관부처 | 해양수산부 Ministry of Oceans and Fisheries |
등록번호 | TRKO202000029760 |
과제고유번호 | 1525009070 |
사업명 | 미래해양산업기술개발사업(R&D) |
DB 구축일자 | 2020-10-10 |
키워드 | 해양천연물.신약개발 선도물질.해양생명공학.대량생산.약학적 평가.Bioactive marine natural products.Lead compound for drμg development.Marine biotechnology.Mass production.Pharmacological evaluation. |
본 미래해양산업기술개발사업 수행을 통해 해양미생물 유래 생리활성 신물질들의 미생물 공정을 통한 생명공학적 대량생산 기술을 개발하고, 후속 응용연구를 위한 물질소재와 기술정보를 확보하였음. 구체적으로, 대상 약물의 생산 균주에 대한 미생물학적 특성 규명 및 생합성 경로 해석, 생산 유전자 집단의 선별, 미생물공학적/유전학적 기법을 활용하여 생산균주를 개량하였고, 이를 활용하여 효율적인 대량생산공정을 구축하였음. 또한, 최종개발 대상물질로 선정된 물질들의 신약 소재화 및 산업화연구를 위해, 다수의 유효성 및 안전성 자료를 확보하였음.
본 미래해양산업기술개발사업 수행을 통해 해양미생물 유래 생리활성 신물질들의 미생물 공정을 통한 생명공학적 대량생산 기술을 개발하고, 후속 응용연구를 위한 물질소재와 기술정보를 확보하였음. 구체적으로, 대상 약물의 생산 균주에 대한 미생물학적 특성 규명 및 생합성 경로 해석, 생산 유전자 집단의 선별, 미생물공학적/유전학적 기법을 활용하여 생산균주를 개량하였고, 이를 활용하여 효율적인 대량생산공정을 구축하였음. 또한, 최종개발 대상물질로 선정된 물질들의 신약 소재화 및 산업화연구를 위해, 다수의 유효성 및 안전성 자료를 확보하였음. 이와 함께, 개발 대상 약물의 CMC 자료 (화학적 특성자료, 분석법/확인법 개발, 기전 연구 등) 등을 확보하여 실제적인 신약개발연구에 요구되는 원천자료들을 완비하였음.
(출처 : 요약서 3p)
Purpose & Contents
◆ Marine natural products are widely recognized to possess immense potential to be developed for a wide range of industrial agents such as new drμgs. Despite the finding and definement of numerous bioactive compounds, however, industrial development of marine natural products a
Purpose & Contents
◆ Marine natural products are widely recognized to possess immense potential to be developed for a wide range of industrial agents such as new drμgs. Despite the finding and definement of numerous bioactive compounds, however, industrial development of marine natural products are severely limited mainly due to the difficulty of both mass supply of potential agents and its economical aspects
◆ Targeting structurally unique and potently bioactive compounds from marine-derived microorganisms, the purpose of this research project is first, biotechnological development of mass production method of bioactive marine compounds for advanced research. For this, bioactive compounds would be quantitatively obtained by utilizing the newly developed methodological approaches
◆ In addition, biotechnological evaluation of selected compounds and their producing microbes followed by the modifications would be pursued for the access to the pre-clinical trials for new drμgs. Target compounds would be also extensively evaluated for their pharmacological potential as new leads for drμg development
◆ Overall the ultimate objective of this project is the establishment of a practical linkage between the basic marine natural product research and industrial development
Results
◆ Based upon the results of 3-years comprehensive research, two lead compounds for the practical drμg development research were successfully established Throμgh this process, new technical methods for the advanced research on marine natural product-based drμg development were developed.
These methods mainly focussed on the comprehensive biotechnological development of efficient mass-supply in both production and separation of lead compounds. In addition, 3 microbial strains, natural or mutated, were also established for these.
◆ Also extensively evaluated were the diverse pharmacological potentials of target compounds for the successful access to pre-clinical steps
◆ By pursing these, the efficient and versatile strategies and methodology were established for not only the drμg development but also wide range of industrial development of marine natural products and their producing organisms
Expected Contribution
◆ The developed results of this research, lead compounds and their producing microbial strains would be directly utilized for the advanced steps of drμg development such as pre-clinical trial. The developed methods and techniques for thereof process would be also thoroμghly utilized and contributed for the same purpose. In addition to the drμg developments, all of the above-mentioned results, as providing materials and information bases, would be widely utilized for R&D on many related fields such as medicinal sciences, basic science and biotechnology, etc, thus immensely contribute to the progress of these fields
◆ The success of this project would bring the direct financial outcome by licensing-out of patents and/or collaborated drμg development with industry. In addition, from the aspects of scope and level of domestic R&D, the success of this project would greatly contribute to the marine biotechnology and natural products based research in general
◆ In addition, this project would greatly contributed to the public interest on marine-related science and serve as a catalyst for analogous R&D
(출처 : SUMMARY 4p)
과제명(ProjectTitle) : | - |
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연구책임자(Manager) : | - |
과제기간(DetailSeriesProject) : | - |
총연구비 (DetailSeriesProject) : | - |
키워드(keyword) : | - |
과제수행기간(LeadAgency) : | - |
연구목표(Goal) : | - |
연구내용(Abstract) : | - |
기대효과(Effect) : | - |
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