초록

1. 줄기세포 유래 도파민 신경 오가노이드 제작
2. In vivo 도파민 신경과 유사한 기능 확인
3. 도파민 신경 오가노이드를 통해 파킨슨병 질병모델 제작 성공
3. 도파민 신경 오가노이드를 통한 파킨슨병 세포치료제로의 가능성 확인

(출처 : 요약서 3p)

Abstract ▼

□ Purpose&Contents
The purpose of the research proposal is to develop dopamine neuron organoid based cell therapy for Parkison’s disease. The dopamine neuronsorganoid will provide a novel platform of 3D disease model as well as celltherapeutics for Parkinson’s disease.
Development of DA neuron

□ Purpose&Contents
The purpose of the research proposal is to develop dopamine neuron organoid based cell therapy for Parkison’s disease. The dopamine neuronsorganoid will provide a novel platform of 3D disease model as well as celltherapeutics for Parkinson’s disease.
Development of DA neuron organoids
1. Generation of stem cell derived DA neuron organoid
2. Mechanism of the generation of DA neuron organoid
Efficacy and safety of DA neuron organoid based disease modeling and cell therapy for Parkinson’s disease
1. DA neruon organoid based 3D disease modeling
2. Efficacy of DA neruon organoid based cell therapy for Parkinson’s disease
3. Generation of DA neuron organoid buds for the cell transplantation

□ Results
Organoids can be derived for a number of organs from human pluripotent stem cells (PSCs). Like organogenesis in vivo, organoids self-organize through both cell sorting out and spatially restricted lineage commitment of precursor cells. Organoids can be used to model disease by introducing disease mutations or using patient-derived PSCs. Future applications could include drug testing and even tissue replacement therapy.

□ Expected Contribution
The therapeutic promise of organoids is perhaps the area with greatest potential. These unique tissues have the potential to model developmental disease, degenerative conditions of Parkinson’s disease. Also, tissues derivedin vitro could be generated from patient cells to provide alternative organreplacement strategies.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제출문 ... 2
• 보고서 요약서 ... 3
• 요약문 ... 4
• SUMMARY ... 5
• Contents ... 6
• 목차 ... 6
• 1. 연구개발과제의 개요 ... 7
• 2. 국내외 기술개발 현황 ... 8
• 3. 연구수행 내용 및 결과 ... 12
• 4. 목표달성도 및 관련분야 기여도 ... 47
• 4-1. 목표달성도 ... 47
• 4-2. 관련분야 기여도 ... 48
• 5. 연구결과의 활용계획 ... 48
• 6. 연구과정에서 수집한 해외과학기술정보 ... 51
• 7. 연구개발성과의 보안등급 ... 51
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 52
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 53
• 10. 연구개발과제의 대표적 연구실적 ... 54
• 11. 기타사항 ... 54
• 12. 참고문헌 ... 55
• 별첨4. 실적 증빙자료 ... 56
• 끝페이지 ... 106