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[미국특허] Protein from brucella species

미국(US) | 공개 | 출원인 : | 출원번호 : US-0785689 ( 2001-02-20 ) | 공개번호 : US-0082170 (2003-05-01) | IPC : A01N-037/18; A61K-038/00; C12P-021/04; A61K-039/395; A61K-039/02; C07K-001/00; C07K-014/00; C07K-017/00; C07K-016/00 A 28 kDa protein which has use as a diagnostic agent for identifying antibodies to Brucella species and as vaccines to raise antibodies against several species of Brucella has been purified.

원문보기

A 28 kDa protein which has use as a diagnostic agent for identifying antibodies to Brucella species and as vaccines to raise antibodies against several species of Brucella has been purified.

[미국특허] Mutants of Brucella melitensis

미국(US) | 등록 | 출원인 : The United States of America as represented by the Secretary of the Army; | 출원번호 : US-0855714 ( 1997-05-08 ) | 특허번호 : US-5939075 (1999-08-17) | IPC : A61K-039/02; A01N-063/00; C12P-001/00; C12P-021/06 The vaccines are prepared by isolating the Brucella genes complementing mutations in the purEK genes of Escherichia coli, physically mapping, determining the DNA sequence, constructing a defined deletion mutation by polynucleotide chain reaction (PCR), introducing a selectable marker into the deletion, and then selecting a purE mutant in Brucella arising by allelic exchange. The resulting Brucella require purines for growth because they lack the purE gene product that is required for the carboxylation of 5'-phosphoribosyl-5-aminoimidazole.

원문보기

The vaccines are prepared by isolating the Brucella genes complementing mutations in the purEK genes of Escherichia coli, physically mapping, determining the DNA sequence, constructing a defined deletion mutation by polynucleotide chain reaction (PCR), introducing a selectable marker into the deletion, and then selecting a purE mutant in Brucella arising by allelic exchange. The resulting Brucella require purines for growth because they lack the purE gene product that is required for the carboxylation of 5'-phosphoribosyl-5-aminoimidazole.

[국제특허] VACCINE AGAINST BRUCELLA ABORTUS

국제(WO) | 공개 | 출원인 : THE TEXAS A & M UNIVERSITY SYSTEM; | 출원번호 : US-0001000 ( 1988-03-29 ) | 특허번호 : WO-8807374 (1988-10-06) | IPC : A61K-039/10; C12N-015/00 The present invention relates to an improved vaccine against Brucella abortus. Specifically, the invention is a novel vaccine in which specific antigens of Brucella abortus are combined to induce an immunological response which provides protective immunity yet permits differentiation between field strain infected and vaccinated cattle.

원문보기

The present invention relates to an improved vaccine against Brucella abortus. Specifically, the invention is a novel vaccine in which specific antigens of Brucella abortus are combined to induce an immunological response which provides protective immunity yet permits differentiation between field strain infected and vaccinated cattle.

[미국특허] BRUCELLA CANIS VACCINE FOR DOGS

미국(US) | 공개 | 출원인 : Arenas Gamboa, Angela M.; | 출원번호 : 16757509 ( 2018-10-19 ) | 공개번호 : 20200237891 (2020-07-30) | IPC : A61K-039/02(2006.01); C12N-001/36(2006.01) Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.

원문보기

Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.

[국제특허] ATTENUATED BRUCELLA MELITENSIS MUTANTS

국제(WO) | 공개 | 출원인 : WISCONSIN ALUMNI RESEARCH FOUNDATION;RAJASHEKARA, Gireesh;SPLITTER, Gary; | 출원번호 : US-0061530 ( 2006-12-01 ) | 공개번호 : WO-7120309 (2008-05-02) | IPC : A61K-039/10(2006.01); C07K-014/23(2006.01) Certain attenuated mutants of Brucella, especially B. melitensis,B. abortus, B. suis and B. ovis, when administered to a human oranimal trigger a protective immune response such that subsequent challengewith virulent Brucella of the same species does not result in disease or resultsin much less severe symptoms. Functional inactivation of galE, a virB gene orthe operon (ORFs 1087- 1090) comprising the gene encoding �i-hexosaminidase(BMEI1087) and a lytic murein transglycosylase gene (BMEI1088). A specificexample of the attenuated galE mutant which produces a protective immune responseis B. melitensis GR024. The specific example of an inactivated ORF1087-1090operon is B. melitensis GR026; it has an insertion mutation in the promoterregion upstream of ORF 1090. Vaccination with live cells of either or both of thesemutants results in a T cell response which protects the human or animal againstchallenge with virulent B. melitensis. Similar strategies for protectiveimmunity using live attenuated mutants are useful for B. abortus, B.suis and B. ovis as well.

원문보기

Certain attenuated mutants of Brucella, especially B. melitensis,B. abortus, B. suis and B. ovis, when administered to a human oranimal trigger a protective immune response such that subsequent challengewith virulent Brucella of the same species does not result in disease or resultsin much less severe symptoms. Functional inactivation of galE, a virB gene orthe operon (ORFs 1087- 1090) comprising the gene encoding �i-hexosaminidase(BMEI1087) and a lytic murein transglycosylase gene (BMEI1088). A specificexample of the attenuated galE mutant which produces a protective immune responseis B. melitensis GR024. The specific example of an inactivated ORF1087-1090operon is B. melitensis GR026; it has an insertion mutation in the promoterregion upstream of ORF 1090. Vaccination with live cells of either or both of thesemutants results in a T cell response which protects the human or animal againstchallenge with virulent B. melitensis. Similar strategies for protectiveimmunity using live attenuated mutants are useful for B. abortus, B.suis and B. ovis as well.

[국제특허] BRUCELLA CANIS VACCINE FOR DOGS

국제(WO) | 공개 | 출원인 : THE TEXAS A&M UNIVERSITY SYSTEM; | 출원번호 : US2018/056703 ( 2018-10-19 ) | 공개번호 : 2019/079716 (2019-04-25) | IPC : C12N-001/36(2006.01); C12N-001/21(2006.01); C12Q-001/689(2018.01) Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.

원문보기

Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.

[유럽특허] VACCINE AGAINST -i(BRUCELLA ABORTUS)

유럽(EP) | 공개 | 출원인 : THE TEXAS A&M UNIVERSITY SYSTEM; | 출원번호 : EP-0903656 ( 1988-03-29 ) | 특허번호 : EP-0357642 (1990-03-14) | IPC : A61K-039/10; C12N-015/00 The present invention relates to an improved vaccine against Brucella abortus. Specifically, the invention is a novel vaccine in which specific antigens of Brucella abortus are combined to induce an immunological response which provides protective immunity yet permits differentiation between field strain infected and vaccinated cattle.

원문보기

The present invention relates to an improved vaccine against Brucella abortus. Specifically, the invention is a novel vaccine in which specific antigens of Brucella abortus are combined to induce an immunological response which provides protective immunity yet permits differentiation between field strain infected and vaccinated cattle.

[국제특허] IMPROVED VACCIN AGAINST BRUCELLA ABORTUS

국제(WO) | 공개 | 출원인 : THE TEXAS A & M UNIVERSITY SYSTEM; | 출원번호 : US-0001681 ( 1993-02-25 ) | 특허번호 : WO-9316728 (1993-09-02) | IPC : A61K-039/10; C12P-021/00; C12P-021/02; C07K-015/04 The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.

원문보기

The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.

[유럽특허] IMPROVED VACCIN AGAINST BRUCELLA ABORTUS

유럽(EP) | 공개 | 출원인 : TEXAS A&M UNIVERSITY SYSTEM; | 출원번호 : EP-0907031 ( 1993-02-25 ) | 특허번호 : EP-0627935 (1994-12-14) | IPC : A61K-039/10; C12P-021/00; C12P-021/02; C07K-015/04 The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.

원문보기

The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.

[미국특허] Brucella canis vaccine for dogs

미국(US) | 등록 | 출원인 : THE TEXAS A&M UNIVERSITY SYSTEM; | 출원번호 : 16757509 ( 2018-10-19 ) | 특허번호 : 11717566 (2023-08-08) | 등록번호 : 11717566 (2023-08-08) | IPC : A61K-039/02(2006.01); A61K-039/10(2006.01); C12N-001/36(2006.01) Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.

원문보기

Methods and compositions for the treatment of Brucella induced diseases and disorders are disclosed herein. In preferred embodiments, the invention relates to a vaccine compositions and methods of vaccinating comprising: a Brucella canis comprising one or more attenuating gene knockouts; and a pharmaceutically acceptable vaccine carrier.

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