[논문]Pharmacokinetics of [3H]Biotin Bound to Different Avidin Analogues

Kang, Young-Sook; Saito, Yasunari; Pardridge, William M.

doi:10.3109/10611869509059215

Pharmacokinetics of [3H]Biotin Bound to Different Avidin Analogues

Journal of drug targeting, v.3 no.2, 1995년, pp.159 - 165

Kang, Young-Sook , Saito, Yasunari , Pardridge, William M.

Abstract ▼ AI-Helper

The use of avidin-biotin technology in drug delivery facilitates the conjugation of biotinylated therapeutics to transport vectors that are enabled to undergo receptor-mediated transcytosis through the brain capillary endothelial wall, which makes up the blood-brain barrier (BBB) in vivo. However, the conjugation of avidin, a cationic glycosylated protein, to transport vectors greatly increases the rate of removal of the vector from the bloodstream, owing to rapid uptake of avidin by peripheral tissues such as liver and kidney. However, modified avidins may retain high affinity biotin binding properties, but may not be rapidly removed from plasma by peripheral tissues, and such avidin analogues would provide preferred plasma pharmacokinetic profiles. Therefore, the present studies investigate the pharmacokinetics of plasma removal of [3H]biotin bound to one of six different avidin analogues: streptavidin, Neutra-lite avidin, avidin, neutral avidin, Lite-avidin, and succinylated avidin. Isoelectric focusing studies show that avidin and Lite-avidin were highly cationic proteins, whereas neutral avidin, Neutra-lite avidin, and streptavidin were neutral proteins, and succinylated avidin had an acidic isoelectric point. The avidin analogues fell into two groups with respect to rate of biotin removal from plasma. The low clearance group included streptavidin and Neutra-lite avidin, which had a mean plasma clearance of 0.41 mL/min/kg. The high clearance group consisted of succinylated avidin, neutral avidin, and Lite-avidin and had a mean plasma clearance of 17 mL/min/kg, or 40-fold faster than the low clearance avidins.(ABSTRACT TRUNCATED AT 250 WORDS)

참고문헌 (21)

Pharmacokinetics Gibaldi M. 1982 10.1201/b14095
Gitlin, G, Bayer, E A, Wilchek, M. Studies on the biotin-binding sites of avidin and streptavidin. Tyrosine residues are involved in the binding site. The Biochemical journal, vol.269, no.2, 527-530.

상세보기
10.1016/0076-6879(90)84259-J
Hiller, Y, Gershoni, J M, Bayer, E A, Wilchek, M. Biotin binding to avidin. Oligosaccharide side chain not required for ligand association. The Biochemical journal, vol.248, no.1, 167-171.

상세보기
J. Pharmacol. Exp. Ther. Kang Y.-S. 344 269 1994

상세보기
Kang, Young-Sook, Pardridge, William M.. Brain Delivery of Biotin Bound to a Conjugate of Neutral Avidin and Cationized Human Albumin. Pharmaceutical research, vol.11, no.9, 1257-1264.

상세보기
J. Nucl. Med. Klibanov A. L. 1951 29 1988
Oldendorf, W. H., Hyman, S., Braun, L., Oldendorf, S. Z.. Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection. Science, vol.178, no.4064, 984-986.

상세보기
Pardridge W. M. Peptide Drug Delivery to the Brain. Raven Press, NY (1991); 1-357
Pardridge, W.M., Boado, R.J.. Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein. FEBS letters, vol.288, no.1, 30-32.

상세보기
Pardridge, William M., Boado, Ruben J., Buciak, Jody L.. Drug delivery of antisense oligonucleotides or peptides to tissuesin vivousing an avidin-biotin system. Drug delivery, vol.1, no.1, 43-50.

상세보기
J. Pharmacol. Exp. Ther. Pardridge W. M. 1175 261 1992

상세보기
SCHECHTER, Bilha, SILBERMAN, Rogerio, ARNON, Ruth, WILCHEK, Meir. Tissue distribution of avidin and streptavidin injected to mice : Effect of avidin carbohydrate, streptavidin truncation and exogenous biotin. European journal of biochemistry, vol.189, no.2, 327-331.

상세보기
Shi, Fenglin, Bailey, Carole, Malick, A. Waseem, Audus, Kenneth L.. Biotin Uptake and Transport Across Bovine Brain Microvessel Endothelial Cell Monolayers. Pharmaceutical research, vol.10, no.2, 282-288.

상세보기
J. Nucl. Med. Sinitsyn V. V. 66 30 1989
Smith, Q.R., Ziylan, Y.Z., Robinson, P.J., Rapoport, S.I.. Kinetics and distribution volumes for tracers of different sizes in the brain plasma space. Brain research, vol.462, no.1, 1-9.

상세보기
Spector, Reynold, Mock, Donald. Biotin Transport Through the Blood‐Brain Barrier. Journal of neurochemistry, vol.48, no.2, 400-404.

상세보기
Wei, R. D., Kou, D. H., Hoo, S. L.. Dissociation of avidin-biotin complex in vivo. Experientia, vol.27, no.4, 366-368.

상세보기
10.1007/978-1-4471-3479-4_4
Yamasaki, R.Bryan, Vega, Antonio, Feeney, Robert E.. Modification of available arginine residues in proteins by p-hydroxyphenylglyoxal. Analytical biochemistry, vol.109, no.1, 32-40.

상세보기
J. Pharmacol. Exp. Ther. Yoshikawa T. 897 263 1992

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Pharmacokinetics of [3H]Biotin Bound to Different Avidin Analogues

Abstract ▼ AI-Helper

참고문헌 (21)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트