This study was examin the potential of Persicaria thunbergii extracts as physiologically active cosmetic ingredients. Ethanol and hot-water extracts of P. thunbergii were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method for antioxidant activity, MTT assay for cell viability in RBL-2H3 and RAW 264.7 cells, paper diffusion assay for anti-microbial activity against Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes, inhibition of nitric oxide (NO) production for anti-inflammatory effect and inhibition of β-hexosaminidase for anti-allergy effect. The polyphenol contents of P. thunbergii ethanol and hot-water extracts were 132.00 and 89.46 μg/mL, respectively. And total flavonoid contents of P. thunbergii ethanol and hot-water extracts were 115.27, 84.94 μg/mL, respectively. The anti-oxidative activity of the two P. thunbergii extracts was compared, and the anti-oxidative activity of the ethanol extract was found to be superior to that of the hot-water extract. The DPPH radical scavenging activity was found to be 79.80% for the ethanol extract and 70.33% for the hot-water extract at a concentration of 500 μg/mL. No significant cytotoxicity was observed in RAW 264.7 and RBL-2H3 cells. In addition, the concentration dependent antimicrobial activities of two extracts were demonstrated in 3 microbial strains, such as those of S. aureus, S.epidermidis, and P. acnes. The anti-inflammatory activity of two extracts was examined in RAW 264.7 cells, and nitric oxide (NO) production was suppressed in a concentration-dependent manner. Both ethanol and hot-water extracts also inhibited secretion of β- hexosaminidase in a concentration-dependent manner. Based on the findings from this study, P. thunbergii extracts could be used as functional cosmetic ingredients that possess anti-oxidative, anti-microbial, anti-inflammatory, and anti-allergy properties. In order to determine their applicability, further research should be systematically conducted to verify their efficacy through clinical studies in humans.
This study was examin the potential of Persicaria thunbergii extracts as physiologically active cosmetic ingredients. Ethanol and hot-water extracts of P. thunbergii were examined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method for antioxidant activity, MTT assay for cell viability in RBL-2H3 and RAW 264.7 cells, paper diffusion assay for anti-microbial activity against Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes, inhibition of nitric oxide (NO) production for anti-inflammatory effect and inhibition of β-hexosaminidase for anti-allergy effect. The polyphenol contents of P. thunbergii ethanol and hot-water extracts were 132.00 and 89.46 μg/mL, respectively. And total flavonoid contents of P. thunbergii ethanol and hot-water extracts were 115.27, 84.94 μg/mL, respectively. The anti-oxidative activity of the two P. thunbergii extracts was compared, and the anti-oxidative activity of the ethanol extract was found to be superior to that of the hot-water extract. The DPPH radical scavenging activity was found to be 79.80% for the ethanol extract and 70.33% for the hot-water extract at a concentration of 500 μg/mL. No significant cytotoxicity was observed in RAW 264.7 and RBL-2H3 cells. In addition, the concentration dependent antimicrobial activities of two extracts were demonstrated in 3 microbial strains, such as those of S. aureus, S.epidermidis, and P. acnes. The anti-inflammatory activity of two extracts was examined in RAW 264.7 cells, and nitric oxide (NO) production was suppressed in a concentration-dependent manner. Both ethanol and hot-water extracts also inhibited secretion of β- hexosaminidase in a concentration-dependent manner. Based on the findings from this study, P. thunbergii extracts could be used as functional cosmetic ingredients that possess anti-oxidative, anti-microbial, anti-inflammatory, and anti-allergy properties. In order to determine their applicability, further research should be systematically conducted to verify their efficacy through clinical studies in humans.
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