Abstract ▼ AI-Helper

A type of polycystic ovary resembling some aspects of human polycystic ovarian syndrome can be induced in the rat with a single injection of long-acting estradiol valerate(EV). Among several theories behind the polycystic ovary, the involvement of sympathetic nervous system draws much attention. Thi...

A type of polycystic ovary resembling some aspects of human polycystic ovarian syndrome can be induced in the rat with a single injection of long-acting estradiol valerate(EV). Among several theories behind the polycystic ovary, the involvement of sympathetic nervous system draws much attention. This study was conducted to prove the possible hypothesis of neurogenic participation in the form of nerve growth factor(NGF) in the pathology of ovarian dysfunction. ChangbuDodamTang (CDT) used in the present study is known to relieve the abnormal symptoms of polycystic ovary. The morphological changes of ovaries were also evaluated. The administration of CDT was done every other day for 60 days. The results from CDT treatment were compared to those from oil-treated control group and EV-injected group. The nerve growth factor was analyzed in the central nervous system and ovaries by immunocytochemistry. The main findings of the present study were 1) polycystic ovary was fully developed in the rat with a single intramuscular injection of estradiol valerate, 2) polycystic ovary resulted in the expression of NGF-immunoreactive material in the ovaries and the brain tissues, and 3) CDT administration significantly decreased the elevated NGF staining in the ovaries without affecting the brain tissues.

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