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용어보기논문에서 용어와 풀이말을 자동 추출한 결과로, 시범 서비스 중입니다. AI-Helper

ACE 억제제로서 고혈압치료제인 cilazapril의 합성에 대하여 연구하였다. cilazapril의 합성시 중간물질인 (S)-1-benzyloxycarbonyl hexahydro-pyri dazine-3-carboxylic acid tert-butylester는 일반적인 아미노산인 L-gluta mic acid로부터 11개의 단계를 거쳐 12.7%의 수득률...

ACE 억제제로서 고혈압치료제인 cilazapril의 합성에 대하여 연구하였다. cilazapril의 합성시 중간물질인 (S)-1-benzyloxycarbonyl hexahydro-pyri dazine-3-carboxylic acid tert-butylester는 일반적인 아미노산인 L-gluta mic acid로부터 11개의 단계를 거쳐 12.7%의 수득률로 얻어냈고, 또 다른 중간물질인 (S)-4-[(benzyloxy) carbonyl]-2-phthalimidobutanoic acid도 같은 출발물질인 L-glutamic acid로부터 2개의 단계를 거쳐 76%의 수득률로 얻어냈다. 또한, (R)-4-phenyl-2-[[(trifluoromethyl)sulfonyl]oxy]butanoic acid ethylester도 합성하였다.

Abstract ▼ AI-Helper

Synthetic studies on cilazapril, a hypertension drug as an ACE inhibitor, have been investigated. Intermediate (S)-1-benzyloxy-carbonyl hexahydro-pyridazine-3-carboxylic acid tert-butyl ester was synthesized by 12.7% yields from L-glutamic acid via 11 steps. The intermediate (S)-4-[(benzyloxy)carbon...

Synthetic studies on cilazapril, a hypertension drug as an ACE inhibitor, have been investigated. Intermediate (S)-1-benzyloxy-carbonyl hexahydro-pyridazine-3-carboxylic acid tert-butyl ester was synthesized by 12.7% yields from L-glutamic acid via 11 steps. The intermediate (S)-4-[(benzyloxy)carbonyl]-2-phthalimidobutanoic acid was obtained from L-glutamic acid via 2steps with 76% yields. (R)-4-phenyl-2-[[(trifluoromethyl)sulfonyl]oxy]butanoic acid ethylester was also prepared.

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