대추씨(Zizyphus jujuba seed) 생리활성물질이 고지혈증 및 당뇨유발 흰쥐의 생체내 지질대사에 미치는 영향 Effects of the Physiological Activity Substance of Zizyphus jujuba Seed Extract on Lipid Metabolism in Hyperlipidemic and Streptozotocin-Induced Diabetic Rats원문보기
약용 및 가공 식품 등의 재료로 활용되고 있는 대추의 가공 부산물 중 대추씨(Zizyphus jujuba seed)의 각종 생리활성물질을 구명하여 생체 대사학적 측면에서 검증하고 고지혈증 및 당뇨병 등 성인병 예방과 치료효과에 대한 개선 방안을 검토하고 기능성 건강음료 등의 자원으로서 이용 가능성을 검토하기 위하여 대추씨 중의 각종 성분 분석과 Sprague Dawley계 숫 흰쥐를 이용한 in vivo 실험 결과, 일반 성분은 탄수화물이 89.40%로 대부분을 차지하였으며, 무기질 함량에 있어서는 Mg, Mn, K의 조성 함량이 많았으며, Ca, P, Fe, ...
약용 및 가공 식품 등의 재료로 활용되고 있는 대추의 가공 부산물 중 대추씨(Zizyphus jujuba seed)의 각종 생리활성물질을 구명하여 생체 대사학적 측면에서 검증하고 고지혈증 및 당뇨병 등 성인병 예방과 치료효과에 대한 개선 방안을 검토하고 기능성 건강음료 등의 자원으로서 이용 가능성을 검토하기 위하여 대추씨 중의 각종 성분 분석과 Sprague Dawley계 숫 흰쥐를 이용한 in vivo 실험 결과, 일반 성분은 탄수화물이 89.40%로 대부분을 차지하였으며, 무기질 함량에 있어서는 Mg, Mn, K의 조성 함량이 많았으며, Ca, P, Fe, Zn 등의 지방산이 검출되었다. 한편, 고지혈증 및 당뇨병 유발 실험동물군에 있어서 대추씨의 생리활성물질 추출액을 각각 급여하여 4주간 실험 사육한 결과, 혈청 총 콜레스테롤 농도, 동맥경화지수, LDL 및 LDL-콜레스테롤, 유리콜레스테롤, 콜레스테롤 에스테르, 중성지방, 인지질 농도 및 혈당 농도 등은 대추씨 3.5g% 추출액을 급여함으로써 유의적으로 감소되었으며, HDL-콜레스테롤 농도 및 총 콜레스테롤에 대한 HDL-콜레스테롤의 비등은 높게 나타났다. 또한 AST, ALT, LDH와 ALP의 활성 변동은 대추씨 추출액을 급여함으로써 저하되는 것을 볼 수가 있었다. 이상의 결과들을 미루어 볼 때, 대추씨 중의 생리활성물질이 혈당, 혈청의 지질개선에 효과가 있는 것으로 사료되며, 지질대사 장애 등에서 오는 성인병 예방 및 개선에 효과가 있을 것으로 추정된다.
약용 및 가공 식품 등의 재료로 활용되고 있는 대추의 가공 부산물 중 대추씨(Zizyphus jujuba seed)의 각종 생리활성물질을 구명하여 생체 대사학적 측면에서 검증하고 고지혈증 및 당뇨병 등 성인병 예방과 치료효과에 대한 개선 방안을 검토하고 기능성 건강음료 등의 자원으로서 이용 가능성을 검토하기 위하여 대추씨 중의 각종 성분 분석과 Sprague Dawley계 숫 흰쥐를 이용한 in vivo 실험 결과, 일반 성분은 탄수화물이 89.40%로 대부분을 차지하였으며, 무기질 함량에 있어서는 Mg, Mn, K의 조성 함량이 많았으며, Ca, P, Fe, Zn 등의 지방산이 검출되었다. 한편, 고지혈증 및 당뇨병 유발 실험동물군에 있어서 대추씨의 생리활성물질 추출액을 각각 급여하여 4주간 실험 사육한 결과, 혈청 총 콜레스테롤 농도, 동맥경화지수, LDL 및 LDL-콜레스테롤, 유리콜레스테롤, 콜레스테롤 에스테르, 중성지방, 인지질 농도 및 혈당 농도 등은 대추씨 3.5g% 추출액을 급여함으로써 유의적으로 감소되었으며, HDL-콜레스테롤 농도 및 총 콜레스테롤에 대한 HDL-콜레스테롤의 비등은 높게 나타났다. 또한 AST, ALT, LDH와 ALP의 활성 변동은 대추씨 추출액을 급여함으로써 저하되는 것을 볼 수가 있었다. 이상의 결과들을 미루어 볼 때, 대추씨 중의 생리활성물질이 혈당, 혈청의 지질개선에 효과가 있는 것으로 사료되며, 지질대사 장애 등에서 오는 성인병 예방 및 개선에 효과가 있을 것으로 추정된다.
The purpose of this study was designed to observe the effects of the feeding Zizyphus jujuba seed extract on the improvement of the blood glucose, lipids in the serum of dietary hyperlipidemic and streptozotocin induced diabetic rats(S.D. strain, ♂) fed the wcperimental diets for 4 weeks. Chemical c...
The purpose of this study was designed to observe the effects of the feeding Zizyphus jujuba seed extract on the improvement of the blood glucose, lipids in the serum of dietary hyperlipidemic and streptozotocin induced diabetic rats(S.D. strain, ♂) fed the wcperimental diets for 4 weeks. Chemical components of the physiological activity substance in Zizyphus jujuba seed were analyzed for the use as an funcitional processed products. The proximate compositions of Zizyphus jujuba seed were carbohydrate 89.40%, moisture 8.23%, crude protein 1.22%, crude fat 0.65% and crude ash 0.50%, respectively. The rechest mineral contained in Zizyphus jujuba seed were noticed to be Mg(198.3mg/100g) and followed by Mn(113.0mg/100g), K(100.2mg/100g), Ca(25.6mg/100g), P(25.6mg/100g), Fe(23.5mg/100g), Zn(18.7mg/100g), Cu(7.4mg/100g) and Na(5.3mg/100g). Total amino acid contents of Zizyphus jujuba seed were 1103.12mg/100g, and the major amino acids were proline(235.17mg%), aspartic acid(175.91mg%), gltamic acid9101.46mg%), leucine(50.27mg%), serine(47.71mg%), aspartic acid(47.27mg%), glycine(41.60mg%) and lysine(33.78mg%), respectively. The amount of free amino acids in the protein of Zizyphus jujuba seed were 178.62mg/100g, and the major free amino acids were proline(121.30mg%), alanine(6.01mg%), valine(2.63mg%) and arginine(2.04mg%), respectively. The compositions of major total fatty acid in the lipid Zizyphus jujuba seed were C18:2(n6c) 28.72%, C18:1(n9t) 23.76%, C18:1(n9c) 13.45%, C16:0 13.45% and C20.5(n3) 1.77% in order, respectively. Concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum were significantly higher in the cholesterol administration groups(group 2(cholesterol+ water), 4(cholesterol+ Zizyphus jujuba seed extract)) than those in the control group (group 1, basal diet + water). But the concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum were ramakably lower in the group 4 than those in the group 2. In the streptozotocin (streptozotocin 55mg/kg B.W.) induced diabetic groups(group 3(streptozotocin(I.P.) +water), 5(streptozotocin(I.P.) +Zizyphus jujuba seed extract)), the serum total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose concentrations actions were rather lower in the group 5 than those in the group 3. In the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration, Zizyphus jujuba seed extract administration groups were higher percentage than in the groups 2 and 3. The activities of aspartate aminotransferase(AST), alanine aminotransferase(ALT), lactate dehydrogenase(LDH) and alkaline phosphatase(ALP) in serum were rather lower in the Zizyphus jujuba seed extract administration groups(group 4, 5) than in the cholesterol diet group(group 2) and streptozotocin induced diabetic group (group 3). From the above research, the physioligical activity substances in Zizyphus jujuba seed were effective on the improvement of the blood glucose, lipid compositions in serum of dietary hyperlipidemic and streptozotocin induced diabetic rats. And particularly, physiological activity substance in Zizyphus jujuba seed was more effective therapeutic regimen for the control of metabolic derangements in adult disease.
The purpose of this study was designed to observe the effects of the feeding Zizyphus jujuba seed extract on the improvement of the blood glucose, lipids in the serum of dietary hyperlipidemic and streptozotocin induced diabetic rats(S.D. strain, ♂) fed the wcperimental diets for 4 weeks. Chemical components of the physiological activity substance in Zizyphus jujuba seed were analyzed for the use as an funcitional processed products. The proximate compositions of Zizyphus jujuba seed were carbohydrate 89.40%, moisture 8.23%, crude protein 1.22%, crude fat 0.65% and crude ash 0.50%, respectively. The rechest mineral contained in Zizyphus jujuba seed were noticed to be Mg(198.3mg/100g) and followed by Mn(113.0mg/100g), K(100.2mg/100g), Ca(25.6mg/100g), P(25.6mg/100g), Fe(23.5mg/100g), Zn(18.7mg/100g), Cu(7.4mg/100g) and Na(5.3mg/100g). Total amino acid contents of Zizyphus jujuba seed were 1103.12mg/100g, and the major amino acids were proline(235.17mg%), aspartic acid(175.91mg%), gltamic acid9101.46mg%), leucine(50.27mg%), serine(47.71mg%), aspartic acid(47.27mg%), glycine(41.60mg%) and lysine(33.78mg%), respectively. The amount of free amino acids in the protein of Zizyphus jujuba seed were 178.62mg/100g, and the major free amino acids were proline(121.30mg%), alanine(6.01mg%), valine(2.63mg%) and arginine(2.04mg%), respectively. The compositions of major total fatty acid in the lipid Zizyphus jujuba seed were C18:2(n6c) 28.72%, C18:1(n9t) 23.76%, C18:1(n9c) 13.45%, C16:0 13.45% and C20.5(n3) 1.77% in order, respectively. Concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum were significantly higher in the cholesterol administration groups(group 2(cholesterol+ water), 4(cholesterol+ Zizyphus jujuba seed extract)) than those in the control group (group 1, basal diet + water). But the concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum were ramakably lower in the group 4 than those in the group 2. In the streptozotocin (streptozotocin 55mg/kg B.W.) induced diabetic groups(group 3(streptozotocin(I.P.) +water), 5(streptozotocin(I.P.) +Zizyphus jujuba seed extract)), the serum total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose concentrations actions were rather lower in the group 5 than those in the group 3. In the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration, Zizyphus jujuba seed extract administration groups were higher percentage than in the groups 2 and 3. The activities of aspartate aminotransferase(AST), alanine aminotransferase(ALT), lactate dehydrogenase(LDH) and alkaline phosphatase(ALP) in serum were rather lower in the Zizyphus jujuba seed extract administration groups(group 4, 5) than in the cholesterol diet group(group 2) and streptozotocin induced diabetic group (group 3). From the above research, the physioligical activity substances in Zizyphus jujuba seed were effective on the improvement of the blood glucose, lipid compositions in serum of dietary hyperlipidemic and streptozotocin induced diabetic rats. And particularly, physiological activity substance in Zizyphus jujuba seed was more effective therapeutic regimen for the control of metabolic derangements in adult disease.
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