천연물로부터 피부노화 억제물질을 screening하기 위하여 연구한 결과를 요약하면 다음과 같다. 1. 천연물로부터 극미량의 항산화 활성은 신속, 정확, 간편하게 측정할 수 있는 방법을 확립하였다. 2. 화피의 에탄올 추출물을 Hexane, Ethylacetate, n-b...
천연물로부터 피부노화 억제물질을 screening하기 위하여 연구한 결과를 요약하면 다음과 같다. 1. 천연물로부터 극미량의 항산화 활성은 신속, 정확, 간편하게 측정할 수 있는 방법을 확립하였다. 2. 화피의 에탄올 추출물을 Hexane, Ethylacetate, n-butanol, H_(2)O로 각각 solvent fractionation한 결과 n-butanol층이 가장 강력한 항산화 활성을 나타냈다. 3. n-butanol층을 column chromatography에 의해 분리한 결과 CHCl_(3)-HeOH (1:1) 이동상에서 가장 높은 활성 갖는 물질을 분리하였다. 4. CHCl_(3)-HeOH (1:1)층을 HPLC에 의해 강력한 항산화 활성을 띤 성분을 분리하였다. 5. 강력한 항산화 활성을 갖는 화피Ⅰ으로 명명되는 3-(3,4-dihydroxyphenyl)-4-{[3,4,5- trihydroxy-6-hydroxymethyl)tetra hydro-2H-pyranyl]oxy)-2,5,7-chromanetriol이 밝혀졌고, 화피 Ⅱ로 명명된 3-(3-hydroxyphenyl)-4-{[2,3,4-trihydroxy-5-(hydroxy methyl)cyclohexyl]oxy)-2,5,7-chromanetriol로 밝혀졌다.
천연물로부터 피부노화 억제물질을 screening하기 위하여 연구한 결과를 요약하면 다음과 같다. 1. 천연물로부터 극미량의 항산화 활성은 신속, 정확, 간편하게 측정할 수 있는 방법을 확립하였다. 2. 화피의 에탄올 추출물을 Hexane, Ethylacetate, n-butanol, H_(2)O로 각각 solvent fractionation한 결과 n-butanol층이 가장 강력한 항산화 활성을 나타냈다. 3. n-butanol층을 column chromatography에 의해 분리한 결과 CHCl_(3)-HeOH (1:1) 이동상에서 가장 높은 활성 갖는 물질을 분리하였다. 4. CHCl_(3)-HeOH (1:1)층을 HPLC에 의해 강력한 항산화 활성을 띤 성분을 분리하였다. 5. 강력한 항산화 활성을 갖는 화피Ⅰ으로 명명되는 3-(3,4-dihydroxyphenyl)-4-{[3,4,5- trihydroxy-6-hydroxymethyl)tetra hydro-2H-pyranyl]oxy)-2,5,7-chromanetriol이 밝혀졌고, 화피 Ⅱ로 명명된 3-(3-hydroxyphenyl)-4-{[2,3,4-trihydroxy-5-(hydroxy methyl)cyclohexyl]oxy)-2,5,7-chromanetriol로 밝혀졌다.
The research results of screening of antioxidants for skin from natural product are as follow 1. Develope a method to measure an infinite small quantity of antioxidant activity speedly, accurately and simply. 2. The n-butanol layer of betula platyphylla extracts was acting as most strong antioxidant...
The research results of screening of antioxidants for skin from natural product are as follow 1. Develope a method to measure an infinite small quantity of antioxidant activity speedly, accurately and simply. 2. The n-butanol layer of betula platyphylla extracts was acting as most strong antioxidant activity after solvent fractionating by hexane, ethyl notate, n-butanol and H_(2)O. 3. Got a substance which has strongest antioxidant activity in CHCℓ_(3)-MeOH(1:1) mobile phase after separating t() buthanol layer by column chromatography. 4. Separate a strong antioxidant compounds from CHCℓ_(3)-MeOH (1:1) fraction 5. Identified the strong antioxidant compounds as 3-(3,4-dihydroxy phenyl)-4-{[3,4,5- trihydroxy-6-hydroxymethyl)tetrahydro-2H-pyranyl]oxy}-2,5,7-chromanetriol and 3-(3-hydroxyphenyl)-4-{[2,3,4- trihydroxy-5(hydroxymethyl)cyclo-hexyl]oxy)-2,5,7- chromanetriol from Betula platyphylla. 6. These compounds can use as antioxidant for skin.
The research results of screening of antioxidants for skin from natural product are as follow 1. Develope a method to measure an infinite small quantity of antioxidant activity speedly, accurately and simply. 2. The n-butanol layer of betula platyphylla extracts was acting as most strong antioxidant activity after solvent fractionating by hexane, ethyl notate, n-butanol and H_(2)O. 3. Got a substance which has strongest antioxidant activity in CHCℓ_(3)-MeOH(1:1) mobile phase after separating t() buthanol layer by column chromatography. 4. Separate a strong antioxidant compounds from CHCℓ_(3)-MeOH (1:1) fraction 5. Identified the strong antioxidant compounds as 3-(3,4-dihydroxy phenyl)-4-{[3,4,5- trihydroxy-6-hydroxymethyl)tetrahydro-2H-pyranyl]oxy}-2,5,7-chromanetriol and 3-(3-hydroxyphenyl)-4-{[2,3,4- trihydroxy-5(hydroxymethyl)cyclo-hexyl]oxy)-2,5,7- chromanetriol from Betula platyphylla. 6. These compounds can use as antioxidant for skin.
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