Kochia scoparia S_(CHRAD) (Daepssari in Korean, Chenopodiaceae), which is an annual herbaceous plant of 50-150 cm height, is cultivated in Korea, China, and Japan. The seed of this plant is known as a Chinese herbal medicine, Kochiae Fructus (地膚子), which is listed as an upper grade (上品) in Shen-nung...
Kochia scoparia S_(CHRAD) (Daepssari in Korean, Chenopodiaceae), which is an annual herbaceous plant of 50-150 cm height, is cultivated in Korea, China, and Japan. The seed of this plant is known as a Chinese herbal medicine, Kochiae Fructus (地膚子), which is listed as an upper grade (上品) in Shen-nung pen-ts'ao ching (神農本草經). Kochiae Fructus has been used as a tonic, diuretic, analgesic, and antidote, and has also been used for the treatment of cutaneous pruritus in Chinese and Korean traditional preparations. Likewise, the whole plant (地膚草) itself has been used as a substitute for its seed in the Korean folk medicine, because its seeds harvests are poor. The chemical constituents of this plant have been reported to be comprised of the saponins, alkaloids(seeds), and several phytoecdysones(fresh leaf). As a part of our continuing studies on the bioactive constituents of natural sources, a systematic separation of the whole plant was carried out. As a result, one cerebroside(1), one glyceroglycolipid(3), and a free triterpene acid(5) were isolated from the ethyl acetate soluble fraction by repeated chromatographies followed by HPLC separations. And 8 glycosides of oleanolic acid(6-14) were isolated from the n-butyl alcohol soluble fraction, by repeated silica gel column chromatography and subsequent reversed phase HPLC separation. Their structures have been determined by chemical and spectral evidence. They are as follow. 1: 1-O-β-D- glucopyanosyl-(2S,3R,4E,8Z)-2-(hexadecanoylamido)-4,8-octadecadien-1,3-diol, 1-O-β-D-glucopyanosyl-(2S,3R,4E,8Z)-2-(9-octadecenoylamido)-4,8-octade-cadien-1,3-diol; 3: 1,2-diacyl-3-O-[α-D-galactopyranosyl-(1→6)-O-β-D-galactopyranosyl]glycerol (acyl: 9-hexadecenoate, hexadecanoate, 9,12,15-octadecatrienoate); 5: oleanolic acid; 6: β-D-glucopyranosyl oleanolate; 7: 3-O-β-D-glucuronopyranosyl oleanolic acid; 8: 3-O-β-D-glucuronopyranosyl oleanolic acid methyl ester; 9: 3-O-[β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl] oleanolic acid; 10: 3-O-[β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl] oleanolic acid methyl ester; 11: 3-O-[β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl]-28-O-(β-D-glucopyranosyl) oleanoic acid; 13: 3-O-[β-D-glucopyranosyl(1→2)-(β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl] oleanolic acid; 14: 3-O-[β-D-glucopyranosyl(1→2)-(β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl]-28-O-(β-D-glucopyranosyl) oleanolic acid.
Kochia scoparia S_(CHRAD) (Daepssari in Korean, Chenopodiaceae), which is an annual herbaceous plant of 50-150 cm height, is cultivated in Korea, China, and Japan. The seed of this plant is known as a Chinese herbal medicine, Kochiae Fructus (地膚子), which is listed as an upper grade (上品) in Shen-nung pen-ts'ao ching (神農本草經). Kochiae Fructus has been used as a tonic, diuretic, analgesic, and antidote, and has also been used for the treatment of cutaneous pruritus in Chinese and Korean traditional preparations. Likewise, the whole plant (地膚草) itself has been used as a substitute for its seed in the Korean folk medicine, because its seeds harvests are poor. The chemical constituents of this plant have been reported to be comprised of the saponins, alkaloids(seeds), and several phytoecdysones(fresh leaf). As a part of our continuing studies on the bioactive constituents of natural sources, a systematic separation of the whole plant was carried out. As a result, one cerebroside(1), one glyceroglycolipid(3), and a free triterpene acid(5) were isolated from the ethyl acetate soluble fraction by repeated chromatographies followed by HPLC separations. And 8 glycosides of oleanolic acid(6-14) were isolated from the n-butyl alcohol soluble fraction, by repeated silica gel column chromatography and subsequent reversed phase HPLC separation. Their structures have been determined by chemical and spectral evidence. They are as follow. 1: 1-O-β-D- glucopyanosyl-(2S,3R,4E,8Z)-2-(hexadecanoylamido)-4,8-octadecadien-1,3-diol, 1-O-β-D-glucopyanosyl-(2S,3R,4E,8Z)-2-(9-octadecenoylamido)-4,8-octade-cadien-1,3-diol; 3: 1,2-diacyl-3-O-[α-D-galactopyranosyl-(1→6)-O-β-D-galactopyranosyl]glycerol (acyl: 9-hexadecenoate, hexadecanoate, 9,12,15-octadecatrienoate); 5: oleanolic acid; 6: β-D-glucopyranosyl oleanolate; 7: 3-O-β-D-glucuronopyranosyl oleanolic acid; 8: 3-O-β-D-glucuronopyranosyl oleanolic acid methyl ester; 9: 3-O-[β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl] oleanolic acid; 10: 3-O-[β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl] oleanolic acid methyl ester; 11: 3-O-[β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl]-28-O-(β-D-glucopyranosyl) oleanoic acid; 13: 3-O-[β-D-glucopyranosyl(1→2)-(β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl] oleanolic acid; 14: 3-O-[β-D-glucopyranosyl(1→2)-(β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl]-28-O-(β-D-glucopyranosyl) oleanolic acid.
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#신농본초경 지부초 medicine 한방약 saponin 댑싸리
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