The purpose of this study is to fine a new compound for treatment of hyperlipidemia from marin plants. The 2,3,4-tribromo-4,5-dihydroxybenzylether(TDB) in Ecklonia stolonifera having anti-aging effect was isolated. The derivatives of TDB were chemically synthesized followed confirming their anti-oxi...
The purpose of this study is to fine a new compound for treatment of hyperlipidemia from marin plants. The 2,3,4-tribromo-4,5-dihydroxybenzylether(TDB) in Ecklonia stolonifera having anti-aging effect was isolated. The derivatives of TDB were chemically synthesized followed confirming their anti-oxidant effect against LDL oxidation. Among them, 4-[(butylsufinyl)methyl]-1,2-benzenediol(SMBD) shown the highest anti-oxidant activity was selected for the animal study. C57BL/6J mouse of 40 divided into 4 groups, normal group, control group, simvastatin group and SMBD group. Group of control, simvastatin and SMBD were fed Paigen diet(atherogenic diet) contaning 1.25% cholesterol for 11 weeks while normal group fed diet without cholesterol. From 7th week, 6.6㎍ of simvastatin or SMBD Dissolved in ethanol-PBS buffer was injected into the peritoneal region of mouse everyday and same concentration of PBS buffer containing ethanol was injected to the control group. The cholesterol concentrations of the experimental groups fed paigen diet were increased two fold (p<0.05) compared to that of the normal group. The plasma concentration of SMBD group was decreased by 17%(p<0.05) than control and these cholesterol decreasing effect observed from the SMBD group was comparable to the simvastatin group shown 18% inhibition(p<0.05). Greater effect of SMBD on decreasing LDL-C, 36% inhibition(p<0.05) to the control group, was found and this effect was also comparable to the simvastatin, 33% inhibition(p<0.05). However, triglyceride and HDL-C decreasing effects were not observed in this study. The cholesterol concentration in the liver of SMBD or simvastatin group was decreased by 17 or 20%, respectively but the changes in triglyceride concentration of the liver due to SMBD or simvastatin injection was not observed. The liver toxicity due to high cholesterol diet was seen severly in the control group compared to the normal. The severity of liver toxicity got even worse in the simvastatin group while degree of liver toxicity decreased due to the SMBD informing that SMBD may seem to have a protecting effect of damage from either high cholesterol or simvastatin. Atherosclerosis was not induced by the paigen diet therefore anti-atherogenic effect of SMBD or simvastatin was not observed. It seems that C57BL/6J mouse was not a proper strain to induce athersclerosis by paigen diet(1.25% cholesterol diet) or the duration of the experiment was not long enough to induce the atherosclerosis. To find the possible mechanism of SMBD on decreasing cholesterol, HMG-Co A reductase activity and cholesterol concentration of feces was determined. But non of the expected mechanism was confirmed. The concentration of TBARS in the liver was decreased by 70%(p<0.05) in SMBD group than control, and it is also comparable to that of simvastatin(72%,p<0.05). The antioxidant enzyme activities, catalse, GSH-px, Cu,Zn-SOD, Mn-SOD, were decreased in SMBD and simvastatin groups than those of control due to less production of lipid peroxide in these groups. In Conclusion, the cholesterol lowering effect of SMBD were observed and this effect is comparable to that of simvastatin that is widely used for the treatment of hypercholesterolemia.
The purpose of this study is to fine a new compound for treatment of hyperlipidemia from marin plants. The 2,3,4-tribromo-4,5-dihydroxybenzylether(TDB) in Ecklonia stolonifera having anti-aging effect was isolated. The derivatives of TDB were chemically synthesized followed confirming their anti-oxidant effect against LDL oxidation. Among them, 4-[(butylsufinyl)methyl]-1,2-benzenediol(SMBD) shown the highest anti-oxidant activity was selected for the animal study. C57BL/6J mouse of 40 divided into 4 groups, normal group, control group, simvastatin group and SMBD group. Group of control, simvastatin and SMBD were fed Paigen diet(atherogenic diet) contaning 1.25% cholesterol for 11 weeks while normal group fed diet without cholesterol. From 7th week, 6.6㎍ of simvastatin or SMBD Dissolved in ethanol-PBS buffer was injected into the peritoneal region of mouse everyday and same concentration of PBS buffer containing ethanol was injected to the control group. The cholesterol concentrations of the experimental groups fed paigen diet were increased two fold (p<0.05) compared to that of the normal group. The plasma concentration of SMBD group was decreased by 17%(p<0.05) than control and these cholesterol decreasing effect observed from the SMBD group was comparable to the simvastatin group shown 18% inhibition(p<0.05). Greater effect of SMBD on decreasing LDL-C, 36% inhibition(p<0.05) to the control group, was found and this effect was also comparable to the simvastatin, 33% inhibition(p<0.05). However, triglyceride and HDL-C decreasing effects were not observed in this study. The cholesterol concentration in the liver of SMBD or simvastatin group was decreased by 17 or 20%, respectively but the changes in triglyceride concentration of the liver due to SMBD or simvastatin injection was not observed. The liver toxicity due to high cholesterol diet was seen severly in the control group compared to the normal. The severity of liver toxicity got even worse in the simvastatin group while degree of liver toxicity decreased due to the SMBD informing that SMBD may seem to have a protecting effect of damage from either high cholesterol or simvastatin. Atherosclerosis was not induced by the paigen diet therefore anti-atherogenic effect of SMBD or simvastatin was not observed. It seems that C57BL/6J mouse was not a proper strain to induce athersclerosis by paigen diet(1.25% cholesterol diet) or the duration of the experiment was not long enough to induce the atherosclerosis. To find the possible mechanism of SMBD on decreasing cholesterol, HMG-Co A reductase activity and cholesterol concentration of feces was determined. But non of the expected mechanism was confirmed. The concentration of TBARS in the liver was decreased by 70%(p<0.05) in SMBD group than control, and it is also comparable to that of simvastatin(72%,p<0.05). The antioxidant enzyme activities, catalse, GSH-px, Cu,Zn-SOD, Mn-SOD, were decreased in SMBD and simvastatin groups than those of control due to less production of lipid peroxide in these groups. In Conclusion, the cholesterol lowering effect of SMBD were observed and this effect is comparable to that of simvastatin that is widely used for the treatment of hypercholesterolemia.
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#곰피활성 지질 저하 Ecklonia stolonifera
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