In order to find new radical scavenging active compounds from the marine microorganism, we have investigated the metabolites from 180 speices of the marine fungus. The significant activities (%Inhibition : DPPH 40% >, ONOO- 80% >, ROS 80% >) were observed in the 12 species of marine fungi, such as M...
In order to find new radical scavenging active compounds from the marine microorganism, we have investigated the metabolites from 180 speices of the marine fungus. The significant activities (%Inhibition : DPPH 40% >, ONOO- 80% >, ROS 80% >) were observed in the 12 species of marine fungi, such as MFA002, MFA006, MFA014, MFA038, MFA055, MFA089, MFA124, MFA133, MFA143, MFA153, MFA158, and MFA175. Among them, MFA153 displayed the most significant activity (DPPH : IC_(50) = 2 ㎍/㎖). From the borth MFA153, we have obtained the fraction No. 4, MFA153B4, as the most active metabolite which has the DPPH radical scavenging activity of 0.2㎍/㎖ in the IC_(50) value.
On the other hand, the structure of a new compound, MFA153B4, was assigned to be 1,4-dihydroxy-2-benzylalcohol on the basis of comprehensive spectroscopic and chemical analyses.
In order to find new radical scavenging active compounds from the marine microorganism, we have investigated the metabolites from 180 speices of the marine fungus. The significant activities (%Inhibition : DPPH 40% >, ONOO- 80% >, ROS 80% >) were observed in the 12 species of marine fungi, such as MFA002, MFA006, MFA014, MFA038, MFA055, MFA089, MFA124, MFA133, MFA143, MFA153, MFA158, and MFA175. Among them, MFA153 displayed the most significant activity (DPPH : IC_(50) = 2 ㎍/㎖). From the borth MFA153, we have obtained the fraction No. 4, MFA153B4, as the most active metabolite which has the DPPH radical scavenging activity of 0.2㎍/㎖ in the IC_(50) value.
On the other hand, the structure of a new compound, MFA153B4, was assigned to be 1,4-dihydroxy-2-benzylalcohol on the basis of comprehensive spectroscopic and chemical analyses.
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