Background: With the development of bioengineering techniques for noninvasive characterization of skin pathophysiology, the induction of irritant dermatitis by surfactants has been extensively studied. Objective: We performed this study to compare the skin responses in terms of transepidermal water ...
Background: With the development of bioengineering techniques for noninvasive characterization of skin pathophysiology, the induction of irritant dermatitis by surfactants has been extensively studied. Objective: We performed this study to compare the skin responses in terms of transepidermal water loss (TEWL) and erythema induced by benzalkonium chloride (BAC), a well-known non-corrosive irritant, in comparison with sodium lauryl sulfate (SLS), a representative corrosive Irritant. Methods: We applied 0.1, 0.2, 0.5, 1, and 2% solutions of BAC and SLS on volar forearm skin for 24 hours using large Finn chamber with filter paper disc in 19 normal healthy subjects. Transepidermal water loss (TEWL) and erythema index (E-index) were measured at before, 30 minutes, one day, two days, three days, one week, and two weeks after the removal of the patches. Results: TEWL values of BAC and SLS patch areas were increased according to the concentration. But BAC induced a significantly lower TEWL increase than SLS did at the corresponding concentrations. TEWL induced by BAC was highest at 30 minutes after the removal of the patch, whereas TEWL induced by SLS was highest at one day. TEWL values have recovered with the passage of time to baseline values at 2 weeks after removal of the patch of lower concentrations (0.1, 0.2, 0.5%) of SLS, but showed still significantly high TEWL values on 1% and 2% SLS patch areas. TEWL values of BAC in 0.1, 0.2, 0.5 and 1% concentrations have recovered to the baseline values at 2 weeks after the removal of the patch, but not in 2% BAC patch areas. E-indices of BAC and SLS were increased according to the concentration with similar reaction pattern. E-index induced by BAC was highest at 30 minutes after the removal of the patch, and E-index induced by SLS was highest at 30 minutes or 1 day after the removal of the patch. E-index of each concentration has recovered with the passage of time to baseline values on both BAC and SLS patch areas at 2 weeks. Conclusions: Benzalkonium chlofde showed much lesser damage to skin barier function at the corresponding concentration of SLS showing similar degree of erythema with BAC. Skin barrier induced by corrosive irritant, SLS would need more prolonged recovery time than skin barfer disruption by non-corrosive irritant, BAC. Words : Benzalkonium chloride, Erythema index, Sodium lauryl sulfate, Transepidermal water loss
Background: With the development of bioengineering techniques for noninvasive characterization of skin pathophysiology, the induction of irritant dermatitis by surfactants has been extensively studied. Objective: We performed this study to compare the skin responses in terms of transepidermal water loss (TEWL) and erythema induced by benzalkonium chloride (BAC), a well-known non-corrosive irritant, in comparison with sodium lauryl sulfate (SLS), a representative corrosive Irritant. Methods: We applied 0.1, 0.2, 0.5, 1, and 2% solutions of BAC and SLS on volar forearm skin for 24 hours using large Finn chamber with filter paper disc in 19 normal healthy subjects. Transepidermal water loss (TEWL) and erythema index (E-index) were measured at before, 30 minutes, one day, two days, three days, one week, and two weeks after the removal of the patches. Results: TEWL values of BAC and SLS patch areas were increased according to the concentration. But BAC induced a significantly lower TEWL increase than SLS did at the corresponding concentrations. TEWL induced by BAC was highest at 30 minutes after the removal of the patch, whereas TEWL induced by SLS was highest at one day. TEWL values have recovered with the passage of time to baseline values at 2 weeks after removal of the patch of lower concentrations (0.1, 0.2, 0.5%) of SLS, but showed still significantly high TEWL values on 1% and 2% SLS patch areas. TEWL values of BAC in 0.1, 0.2, 0.5 and 1% concentrations have recovered to the baseline values at 2 weeks after the removal of the patch, but not in 2% BAC patch areas. E-indices of BAC and SLS were increased according to the concentration with similar reaction pattern. E-index induced by BAC was highest at 30 minutes after the removal of the patch, and E-index induced by SLS was highest at 30 minutes or 1 day after the removal of the patch. E-index of each concentration has recovered with the passage of time to baseline values on both BAC and SLS patch areas at 2 weeks. Conclusions: Benzalkonium chlofde showed much lesser damage to skin barier function at the corresponding concentration of SLS showing similar degree of erythema with BAC. Skin barrier induced by corrosive irritant, SLS would need more prolonged recovery time than skin barfer disruption by non-corrosive irritant, BAC. Words : Benzalkonium chloride, Erythema index, Sodium lauryl sulfate, Transepidermal water loss
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