Ho Wang Lee(1928- ) is an eminent Korean scientist who discovered the Hantaan virus, the agent of the epidemic hemorrhagic fever(EHF), in 1976. Only 4 years later he also isolated another agent of EHF, the Seoul virus from a house rat. In addition, he successfully developed a diagnostic kit, Hantadi...
Ho Wang Lee(1928- ) is an eminent Korean scientist who discovered the Hantaan virus, the agent of the epidemic hemorrhagic fever(EHF), in 1976. Only 4 years later he also isolated another agent of EHF, the Seoul virus from a house rat. In addition, he successfully developed a diagnostic kit, Hantadia, and a vaccine named Hantavax, in 1990. As the result, he became an internationally renowned scientist who solved an important question concerning cause, diagnosis, and prevention of old and difficult problems of EHF in Korea. This thesis examines Lee's research on EHF from 1970 to 1980 focusing on the combinations of experimental objects and methods. This period of time is expecially important because it marks the beginning of his work with EHF and gets positive results, his first discovery of an agent of this disease. I analyze his experimental researches for 10 years into three distinct stages: beginning to study and work on EHF, isolating an agent of EHF, and identifying it as Hantaan virus. Also this period can be divided two stages, to discover of Korea Antigen and to register of Hantaan virus. From this I will express the scientist's research process which is composed of experimental objects and methods, it is connected complicatedly. First, during the period of 1970-73, Lee began studying the EHF. At that time he did not know much about EHF. So he reviewed foreign literature of EHF. From the study, he selected wild rats as the experimental object since they had been considered as very probable agent. The study of this period was difficult for him. Because a series of experiments with wild rats failed. So he had to try other experimental objects and methods. At the second stage of 1974-76, during this period he discovered an agent of EHF with his new experimental object and method. Because experiment of last period were failed continuously. So he introduced a new experimental object and method. He used lungs of wild rats, which he and other researchers had never been tried to analyze before. He also applied a new experimental method, Fluorescent Antibody Technique. This experiment succeeded and this combination resulted in the discovery of an agent of EHF, the Korea Antigen. At the final stage from 1977 to 1980 the Korea Antigen was officially recognized as the agent virus of EHF and given the name, the Hantaan virus. Lee needed to certify that its physical chemistry features to recognize Korea Antigen as an agent of EHF. To verify the Korea Antigen to be a virus, he needed to get help from foreign researchers because he had no experimental facilities and experiences for it. In large we are apt to believe that a scientist's study process are connected to the few successful experiments. But when one tries to observe the study process in detail, until derived scientific results are generated from both failures and successes, it is complicated. Lee's discovery of Hantaan virus demonstrates that the results of scientists' research are accomplished through continuous combination of experimental objects and methods.
Ho Wang Lee(1928- ) is an eminent Korean scientist who discovered the Hantaan virus, the agent of the epidemic hemorrhagic fever(EHF), in 1976. Only 4 years later he also isolated another agent of EHF, the Seoul virus from a house rat. In addition, he successfully developed a diagnostic kit, Hantadia, and a vaccine named Hantavax, in 1990. As the result, he became an internationally renowned scientist who solved an important question concerning cause, diagnosis, and prevention of old and difficult problems of EHF in Korea. This thesis examines Lee's research on EHF from 1970 to 1980 focusing on the combinations of experimental objects and methods. This period of time is expecially important because it marks the beginning of his work with EHF and gets positive results, his first discovery of an agent of this disease. I analyze his experimental researches for 10 years into three distinct stages: beginning to study and work on EHF, isolating an agent of EHF, and identifying it as Hantaan virus. Also this period can be divided two stages, to discover of Korea Antigen and to register of Hantaan virus. From this I will express the scientist's research process which is composed of experimental objects and methods, it is connected complicatedly. First, during the period of 1970-73, Lee began studying the EHF. At that time he did not know much about EHF. So he reviewed foreign literature of EHF. From the study, he selected wild rats as the experimental object since they had been considered as very probable agent. The study of this period was difficult for him. Because a series of experiments with wild rats failed. So he had to try other experimental objects and methods. At the second stage of 1974-76, during this period he discovered an agent of EHF with his new experimental object and method. Because experiment of last period were failed continuously. So he introduced a new experimental object and method. He used lungs of wild rats, which he and other researchers had never been tried to analyze before. He also applied a new experimental method, Fluorescent Antibody Technique. This experiment succeeded and this combination resulted in the discovery of an agent of EHF, the Korea Antigen. At the final stage from 1977 to 1980 the Korea Antigen was officially recognized as the agent virus of EHF and given the name, the Hantaan virus. Lee needed to certify that its physical chemistry features to recognize Korea Antigen as an agent of EHF. To verify the Korea Antigen to be a virus, he needed to get help from foreign researchers because he had no experimental facilities and experiences for it. In large we are apt to believe that a scientist's study process are connected to the few successful experiments. But when one tries to observe the study process in detail, until derived scientific results are generated from both failures and successes, it is complicated. Lee's discovery of Hantaan virus demonstrates that the results of scientists' research are accomplished through continuous combination of experimental objects and methods.
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