We prepared nano-emulsified paclitaxel using administration form of the self-microemulsifying drug delivery systems (SMEDDS) in order to increase efficacy of paclitaxel. As paclitaxel delivery carrier, we chose MPEG-PLGA diblock copolymers with different hydrophilic and hydrophobic balances (HLB) by...
We prepared nano-emulsified paclitaxel using administration form of the self-microemulsifying drug delivery systems (SMEDDS) in order to increase efficacy of paclitaxel. As paclitaxel delivery carrier, we chose MPEG-PLGA diblock copolymers with different hydrophilic and hydrophobic balances (HLB) by changing of PLGA segments under constant MPEG segment. Paclitaxel and MPEG-PLGA diblock copolymers were dissolved by solubilizer such as tetraglycol, Cremophor ELP, and Labrasol. The droplet size for all formulations of nano-emulsified paclitaxel was found in the range of 200~300 nm by dynamic light scattering. The prepared SMEDDS showed a spherical shape ofnano-emusion. The storage stability of the nano-emulsified paclitaxels depended on HLB values of MPEG-PLGA diblock copolymers. In conclusion, we confirmed that the formulations tried in this study could be used as administration form of paclitaxel. Osmotic granule system which is one of the drug delivery systems has been developed to improve manufacturing process and other problems of tablet osmotic systems. It consists of water swellable seed layer, drug layer, and drug release controlled membrane layer and manufactured by fluidized bed coater. The osmotic multi-coated granules composed of sugar, various excipients, such as hydroxypropyl cellulose (HPC), lactose, fructose, cellulose acetate (CA), and Eudragit, has been successfuly developed with purpose of delivering Nifedipine. Nifedipine (ND) tablet dosage forms of Adalat (Bayer) are commercialized systems. In this work, novel device of multi-coated pellets contained ND by fluidized-bed spray coating method. Granule size, solubilizer, membrane composition, and drug solubility condition have an effect on drug release from osmotic granule system. Drug release increased as granule size. Also, drug release increased as channeling agent, drug solubility. Drug release increased as hydrophilic composition in membrane increased. From these results, we assured that osmotic granule can be fabricated by fluidized bed coating methods, and the appropriate release profile could be controlled by these factors.
We prepared nano-emulsified paclitaxel using administration form of the self-microemulsifying drug delivery systems (SMEDDS) in order to increase efficacy of paclitaxel. As paclitaxel delivery carrier, we chose MPEG-PLGA diblock copolymers with different hydrophilic and hydrophobic balances (HLB) by changing of PLGA segments under constant MPEG segment. Paclitaxel and MPEG-PLGA diblock copolymers were dissolved by solubilizer such as tetraglycol, Cremophor ELP, and Labrasol. The droplet size for all formulations of nano-emulsified paclitaxel was found in the range of 200~300 nm by dynamic light scattering. The prepared SMEDDS showed a spherical shape ofnano-emusion. The storage stability of the nano-emulsified paclitaxels depended on HLB values of MPEG-PLGA diblock copolymers. In conclusion, we confirmed that the formulations tried in this study could be used as administration form of paclitaxel. Osmotic granule system which is one of the drug delivery systems has been developed to improve manufacturing process and other problems of tablet osmotic systems. It consists of water swellable seed layer, drug layer, and drug release controlled membrane layer and manufactured by fluidized bed coater. The osmotic multi-coated granules composed of sugar, various excipients, such as hydroxypropyl cellulose (HPC), lactose, fructose, cellulose acetate (CA), and Eudragit, has been successfuly developed with purpose of delivering Nifedipine. Nifedipine (ND) tablet dosage forms of Adalat (Bayer) are commercialized systems. In this work, novel device of multi-coated pellets contained ND by fluidized-bed spray coating method. Granule size, solubilizer, membrane composition, and drug solubility condition have an effect on drug release from osmotic granule system. Drug release increased as granule size. Also, drug release increased as channeling agent, drug solubility. Drug release increased as hydrophilic composition in membrane increased. From these results, we assured that osmotic granule can be fabricated by fluidized bed coating methods, and the appropriate release profile could be controlled by these factors.
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