Red pepper (Capsicum annuum L., Solanaceae) is an annual or biannual herbaceous plant that is found in tropical America, Korea, Japan, and India. It flowers from May to June and the fruits ripen from July to September. The ripen fruits are red and 5-10 cm in length. A number of studies have been car...
Red pepper (Capsicum annuum L., Solanaceae) is an annual or biannual herbaceous plant that is found in tropical America, Korea, Japan, and India. It flowers from May to June and the fruits ripen from July to September. The ripen fruits are red and 5-10 cm in length. A number of studies have been carried out on C. annuum fruit, but there are few studies on leaves. Therefor, in this study, the isolation of secondary metabolites was carried out in order to screen for valuable and physiologically active materials.
The leaves of C. annuum L. were extracted two times at room temperature with 80% aqueous MeOH. The extracts were partitioned with H2O, EtOAc and n-BuOH, successively. From the EtOAc fraction, three acyclic diterphenoids, one sesquiterpenoid and one lignan were isolated through the repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the result of spectroscopic data including NMR, MS and IR, the chemical structures of the compounds were determined as alpha-tocopherol (1), phytol (2), vitamin E quinone (3), eudesma-4,8-dien-1beta-ol (4) and tortoside C (5), respectively. These compounds were isolated for the first time from the leaves of C. annuum in this study. Also, three acyclic diterpenoids (compounds 1~3) showed inhibitory activity on human Acyl CoA: cholesterol transferase 1 (hACAT1) by 42.9±0.2%, 55.6±2.7% and 37.0±5.4% at 50 ㎍/ml..
Red pepper (Capsicum annuum L., Solanaceae) is an annual or biannual herbaceous plant that is found in tropical America, Korea, Japan, and India. It flowers from May to June and the fruits ripen from July to September. The ripen fruits are red and 5-10 cm in length. A number of studies have been carried out on C. annuum fruit, but there are few studies on leaves. Therefor, in this study, the isolation of secondary metabolites was carried out in order to screen for valuable and physiologically active materials.
The leaves of C. annuum L. were extracted two times at room temperature with 80% aqueous MeOH. The extracts were partitioned with H2O, EtOAc and n-BuOH, successively. From the EtOAc fraction, three acyclic diterphenoids, one sesquiterpenoid and one lignan were isolated through the repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the result of spectroscopic data including NMR, MS and IR, the chemical structures of the compounds were determined as alpha-tocopherol (1), phytol (2), vitamin E quinone (3), eudesma-4,8-dien-1beta-ol (4) and tortoside C (5), respectively. These compounds were isolated for the first time from the leaves of C. annuum in this study. Also, three acyclic diterpenoids (compounds 1~3) showed inhibitory activity on human Acyl CoA: cholesterol transferase 1 (hACAT1) by 42.9±0.2%, 55.6±2.7% and 37.0±5.4% at 50 ㎍/ml..
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#Capsicum annuum L
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